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Coexpression cluster:C4135

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Full id: C4135_Mast_CD14_CD19_Eosinophils_CD4_CD8_Natural



Phase1 CAGE Peaks

Hg19::chr2:157189816..157189856,+p@chr2:157189816..157189856
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Hg19::chr8:102218069..102218077,+p@chr8:102218069..102218077
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Hg19::chr8:102218099..102218114,+p@chr8:102218099..102218114
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.48e-42136
hematopoietic stem cell2.63e-32168
angioblastic mesenchymal cell2.63e-32168
classical monocyte2.71e-3242
CD14-positive, CD16-negative classical monocyte2.71e-3242
hematopoietic lineage restricted progenitor cell5.15e-32120
hematopoietic cell2.12e-31177
nongranular leukocyte6.92e-31115
hematopoietic oligopotent progenitor cell1.11e-28161
hematopoietic multipotent progenitor cell1.11e-28161
defensive cell4.37e-2648
phagocyte4.37e-2648
myeloid leukocyte4.52e-2672
granulocyte monocyte progenitor cell5.16e-2267
macrophage dendritic cell progenitor2.76e-2061
myeloid lineage restricted progenitor cell6.14e-2066
monopoietic cell8.59e-1959
monocyte8.59e-1959
monoblast8.59e-1959
promonocyte8.59e-1959
myeloid cell8.62e-18108
common myeloid progenitor8.62e-18108
stuff accumulating cell1.97e-1287
lymphoid lineage restricted progenitor cell9.56e-1152
lymphocyte2.43e-1053
common lymphoid progenitor2.43e-1053
nucleate cell1.39e-0955
intermediate monocyte1.06e-089
CD14-positive, CD16-positive monocyte1.06e-089
CD4-positive, alpha-beta T cell3.25e-076
Uber Anatomy
Ontology termp-valuen
bone element2.95e-2082
bone marrow2.99e-2076
hematopoietic system4.31e-2098
blood island4.31e-2098
immune system3.17e-1893
hemolymphoid system5.57e-18108
skeletal element1.56e-1790
skeletal system6.41e-14100


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467214.97544968400580.005768294540793880.0259625458345963
E2F1#186934.907389214879320.008460985347239390.0326108738487779
E2F6#187635.017155731697390.00791769806886330.0323052103220695
MYC#460935.22228187160940.007020843755740150.0295094132729292
NFKB1#479035.488063424193840.006049381815655430.0270077111719419
PAX5#507936.669565531177830.003370290999677260.0173223337458314
SMARCB1#6598318.25271578115740.000164397760679890.00203430541796766
SP1#666735.69838137814090.005403962701712170.0247017008317628
TCF7L2#6934310.77017656313730.0008003181298398380.00614907858179525
TFAP2A#7020211.01242291536330.01054990655215560.0390218759881209



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.