Coexpression cluster:C727

Full id: C727_colon_smooth_rectum_duodenum_bladder_esophagus_prostate

Phase1 CAGE Peaks

Hg19::chr10:71175837..71175884,-	p8@TACR2
Hg19::chr10:71176135..71176147,-	p6@TACR2
Hg19::chr10:71176561..71176571,-	p4@TACR2
Hg19::chr10:71176580..71176586,-	p7@TACR2
Hg19::chr10:71176627..71176638,-	p3@TACR2
Hg19::chr10:71176667..71176679,-	p2@TACR2
Hg19::chr12:95775013..95775020,-	p1@ENST00000549961
Hg19::chr22:31487193..31487207,+	p19@SMTN
Hg19::chr22:31487784..31487801,+	p@chr22:31487784..31487801 +
Hg19::chr2:74143846..74143862,+	p@chr2:74143846..74143862 +
Hg19::chr9:139442039..139442067,+	p1@uc004cib.1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0003012	muscle system process	0.000656532722588068
GO:0006936	muscle contraction	0.000656532722588068
GO:0004995	tachykinin receptor activity	0.00549439764808921
GO:0007217	tachykinin signaling pathway	0.00659298603237552
GO:0003008	system process	0.0161430672631361
GO:0006939	smooth muscle contraction	0.0161430672631361
GO:0007588	excretion	0.0161430672631361
GO:0008307	structural constituent of muscle	0.0161430672631361
GO:0008188	neuropeptide receptor activity	0.0161430672631361
GO:0042923	neuropeptide binding	0.0161430672631361
GO:0030594	neurotransmitter receptor activity	0.0347768246083993
GO:0042165	neurotransmitter binding	0.0347768246083993
GO:0001653	peptide receptor activity	0.0347768246083993
GO:0008528	peptide receptor activity, G-protein coupled	0.0347768246083993
GO:0007517	muscle development	0.0377085351688235
GO:0042277	peptide binding	0.0416847670934325
GO:0032501	multicellular organismal process	0.0416847670934325

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
intestine	7.67e-26	17
gastrointestinal system	3.57e-22	25
adult organism	8.64e-18	114
large intestine	2.15e-17	11
colon	5.23e-14	9
small intestine	6.52e-14	4
male reproductive organ	8.24e-11	11
male genital duct	1.20e-10	3
internal male genitalia	1.20e-10	3
subdivision of digestive tract	9.17e-10	118
vermiform appendix	5.70e-09	1
caecum	5.70e-09	1
midgut	5.70e-09	1
penis	6.16e-09	1
intromittent organ	6.16e-09	1
lateral plate mesenchyme	6.16e-09	1
undifferentiated genital tubercle	6.16e-09	1
somatopleure	6.16e-09	1
uterus or analog	7.18e-09	1
digestive system	9.80e-09	145
digestive tract	9.80e-09	145
primitive gut	9.80e-09	145
vas deferens	1.22e-08	1
spermatic cord	1.22e-08	1
epididymis	1.42e-08	1
male organism	3.25e-08	22
male reproductive system	3.25e-08	22
duct of male reproductive system	3.34e-08	4
endoderm-derived structure	1.16e-07	160
endoderm	1.16e-07	160
presumptive endoderm	1.16e-07	160
lower digestive tract	5.57e-07	5
reproductive structure	6.79e-07	59
reproductive system	6.79e-07	59

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.