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Coexpression cluster:C56

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Full id: C56_heart_left_umbilical_skeletal_penis_diaphragm_tongue



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
6.1282881663948e-050.007758412818655815177Calcium signaling pathway (KEGG):04020
3.29661271431625e-050.00695585282720729477Cardiac muscle contraction (KEGG):04260
4.42943345639642e-050.00700957844474733483Hypertrophic cardiomyopathy (HCM) (KEGG):05410
2.8178069949548e-050.00695585282720729474Arrhythmogenic right ventricular cardiomyopathy (ARVC) (KEGG):05412
2.3046604318716e-060.00145885005337472590Dilated cardiomyopathy (KEGG):05414
0.0001527717039031620.0161174147617836344Heart Development (Wikipathways):WP1591



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005856cytoskeleton3.02581251423143e-06
GO:0015629actin cytoskeleton1.77735874149302e-05
GO:0005515protein binding1.77735874149302e-05
GO:0003779actin binding0.000226266958611217
GO:0008092cytoskeletal protein binding0.000226266958611217
GO:0005737cytoplasm0.000226266958611217
GO:0043228non-membrane-bound organelle0.00048660186084386
GO:0043232intracellular non-membrane-bound organelle0.00048660186084386
GO:0006936muscle contraction0.000972444371781958
GO:0003012muscle system process0.000972444371781958
GO:0042805actinin binding0.00209396948690234
GO:0048513organ development0.00246493934239045
GO:0014855striated muscle cell proliferation0.00246493934239045
GO:0060038cardiac muscle cell proliferation0.00246493934239045
GO:0051179localization0.00665445545063212
GO:0032501multicellular organismal process0.00736201752690342
GO:0044456synapse part0.00935431459775382
GO:0005913cell-cell adherens junction0.00988614168572277
GO:0007517muscle development0.0107637275306919
GO:0016043cellular component organization and biogenesis0.0109570320212676
GO:0006816calcium ion transport0.0123170982480961
GO:0030336negative regulation of cell migration0.0170127041511421
GO:0014706striated muscle development0.0170127041511421
GO:0033002muscle cell proliferation0.0170127041511421
GO:0051234establishment of localization0.0170127041511421
GO:0043229intracellular organelle0.0170127041511421
GO:0043226organelle0.0170127041511421
GO:0048731system development0.0170127041511421
GO:0007507heart development0.0170127041511421
GO:0051271negative regulation of cell motility0.0190113139170204
GO:0044459plasma membrane part0.0194201755717319
GO:0040013negative regulation of locomotion0.0194201755717319
GO:0016528sarcoplasm0.0198434707110117
GO:0016529sarcoplasmic reticulum0.0198434707110117
GO:0048856anatomical structure development0.0206083221838369
GO:0051049regulation of transport0.0214231971388989
GO:0015674di-, tri-valent inorganic cation transport0.0214231971388989
GO:0044464cell part0.0245403105290486
GO:0030029actin filament-based process0.0245403105290486
GO:0044430cytoskeletal part0.0260786360870696
GO:0007010cytoskeleton organization and biogenesis0.0269489767543233
GO:0006810transport0.0269489767543233
GO:0033612receptor serine/threonine kinase binding0.0269489767543233
GO:0004231insulysin activity0.0269489767543233
GO:0060044negative regulation of cardiac muscle cell proliferation0.0269489767543233
GO:0060039pericardium development0.0269489767543233
GO:0008613diuretic hormone activity0.0269489767543233
GO:0032502developmental process0.0285060976477417
GO:0003008system process0.0285060976477417
GO:0005891voltage-gated calcium channel complex0.029529748298574
GO:0008283cell proliferation0.0343463216863682
GO:0045211postsynaptic membrane0.0355730679489877
GO:0044424intracellular part0.0372190023142243
GO:0008015blood circulation0.0372190023142243
GO:0003013circulatory system process0.0372190023142243
GO:0045121lipid raft0.0372190023142243
GO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity0.0372190023142243
GO:0042030ATPase inhibitor activity0.0372190023142243
GO:0005915zonula adherens0.0372190023142243
GO:0031014troponin T binding0.0372190023142243
GO:0060043regulation of cardiac muscle cell proliferation0.0372190023142243
GO:0032387negative regulation of intracellular transport0.0372190023142243
GO:0051890regulation of cardioblast differentiation0.0372190023142243
GO:0016080synaptic vesicle targeting0.0372190023142243
GO:0051891positive regulation of cardioblast differentiation0.0372190023142243
GO:0051371muscle alpha-actinin binding0.0372190023142243
GO:0031013troponin I binding0.0372190023142243
GO:0007206metabotropic glutamate receptor, phospholipase C activating pathway0.0372190023142243
GO:0051649establishment of cellular localization0.0409939404348144
GO:0030016myofibril0.0422151618077535
GO:0030308negative regulation of cell growth0.0422151618077535
GO:0005912adherens junction0.0425870509854035
GO:0045792negative regulation of cell size0.0425870509854035
GO:0008217regulation of blood pressure0.0432258510182351
GO:0051641cellular localization0.0432258510182351
GO:0007154cell communication0.0433862427113786
GO:0005509calcium ion binding0.0433862427113786
GO:0051393alpha-actinin binding0.0433862427113786
GO:0043114regulation of vascular permeability0.0433862427113786
GO:0045822negative regulation of heart contraction0.0433862427113786
GO:0003875ADP-ribosylarginine hydrolase activity0.0433862427113786
GO:0004802transketolase activity0.0433862427113786
GO:0035117embryonic arm morphogenesis0.0433862427113786
GO:0035140arm morphogenesis0.0433862427113786
GO:0006772thiamin metabolic process0.0433862427113786
GO:0051725protein amino acid de-ADP-ribosylation0.0433862427113786
GO:0030334regulation of cell migration0.0433862427113786
GO:0044449contractile fiber part0.0433862427113786
GO:0045926negative regulation of growth0.0439877529669852
GO:0005622intracellular0.0439877529669852
GO:0048519negative regulation of biological process0.0462025731642965
GO:0043292contractile fiber0.0470434621559895
GO:0007267cell-cell signaling0.0490539250625145
GO:0046907intracellular transport0.0490539250625145
GO:0007519skeletal muscle development0.0490539250625145
GO:0005245voltage-gated calcium channel activity0.0490539250625145
GO:0051270regulation of cell motility0.0490539250625145
GO:0010002cardioblast differentiation0.0490539250625145
GO:0006110regulation of glycolysis0.0490539250625145
GO:0007262STAT protein nuclear translocation0.0490539250625145
GO:0030147natriuresis0.0490539250625145
GO:0043034costamere0.0490539250625145
GO:0016068type I hypersensitivity0.0490539250625145



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
primary circulatory organ3.24e-5827
valve6.51e-343
cardiac mesenchyme6.51e-343
cardial valve6.51e-343
tunica intima6.51e-343
heart layer6.51e-343
endocardium6.51e-343
endocardial cushion6.51e-343
presumptive endocardium6.51e-343
cardiac chamber9.10e-343
pulmonary valve2.78e-261
semi-lunar valve2.78e-261
left cardiac atrium3.58e-261
heart4.70e-2624
primitive heart tube4.70e-2624
primary heart field4.70e-2624
anterior lateral plate mesoderm4.70e-2624
heart tube4.70e-2624
heart primordium4.70e-2624
cardiac mesoderm4.70e-2624
cardiogenic plate4.70e-2624
heart rudiment4.70e-2624
mitral valve7.62e-261
heart left ventricle9.79e-261
cardiac ventricle9.79e-261
future cardiac ventricle9.79e-261
compound organ2.94e-2368
blood vessel layer3.53e-157
circulatory system3.77e-14112
cardiac atrium8.28e-142
future cardiac atrium8.28e-142
atrioventricular valve1.21e-132
neural crest-derived structure6.28e-1110
neural crest6.28e-1110
neural fold6.28e-1110
adult organism1.20e-10114
splanchnic layer of lateral plate mesoderm1.01e-0783
Disease
Ontology termp-valuen
heart disease8.50e-502
vascular disease1.26e-251
ischemia1.26e-251
extrinsic cardiomyopathy1.26e-251
myocardial ischemia1.26e-251
myocardial infarction1.26e-251
cardiovascular system disease1.62e-254


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data