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Coexpression cluster:C1158

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Full id: C1158_Small_malignant_Gingival_Keratinocyte_cervical_Mallassezderived_oral



Phase1 CAGE Peaks

Hg19::chr11:94439579..94439590,+p11@AMOTL1
Hg19::chr11:94439591..94439602,+p7@AMOTL1
Hg19::chr11:94439606..94439641,+p2@AMOTL1
Hg19::chr11:94439650..94439668,+p4@AMOTL1
Hg19::chr11:94439679..94439690,+p9@AMOTL1
Hg19::chr14:81790540..81790556,-p@chr14:81790540..81790556
-
Hg19::chr1:209605563..209605577,+p1@MIR205
p2@MIR205HG


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005923tight junction0.0123631225715295
GO:0043296apical junction complex0.0123631225715295
GO:0016327apicolateral plasma membrane0.0123631225715295
GO:0005911intercellular junction0.0152772871776757
GO:0042802identical protein binding0.0252560932532674
GO:0030054cell junction0.0252560932532674



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
oral opening5.74e-1322
orifice8.02e-1336
respiratory system2.20e-1274
mouth2.05e-1029
stomodeum2.05e-1029
surface structure5.21e-1099
anterior region of body7.44e-1062
craniocervical region7.44e-1062
endoderm-derived structure3.29e-09160
endoderm3.29e-09160
presumptive endoderm3.29e-09160
urothelium8.26e-095
ectoderm-derived structure1.15e-07171
ectoderm1.15e-07171
presumptive ectoderm1.15e-07171
neck1.16e-0710
head1.39e-0756
gland of gut2.01e-0710
transitional epithelium3.10e-076
saliva-secreting gland3.14e-076
gland of oral region3.14e-076
gland of foregut3.14e-076
oral gland3.14e-076
oral cavity3.14e-076
respiratory tract5.16e-0754
gingival epithelium7.50e-073
Disease
Ontology termp-valuen
squamous cell carcinoma1.25e-1314


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
POLR2A#543072.147453176558070.004747636447610280.0223300339091182
STAT3#677457.513903569395890.0001381820449413220.0018050774973892
TRIM28#10155513.27894646090188.62103642667186e-060.000234045340100125



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.