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Coexpression cluster:C1032

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Full id: C1032_Mast_Natural_CD4_CD8_CD19_Basophils_CD14



Phase1 CAGE Peaks

Hg19::chr14:50101931..50101969,-p4@DNAAF2
Hg19::chr15:86250415..86250426,-p@chr15:86250415..86250426
-
Hg19::chr16:27247011..27247032,+p@chr16:27247011..27247032
+
Hg19::chr19:16435987..16435993,+p@chr19:16435987..16435993
+
Hg19::chr19:18415466..18415480,-p@chr19:18415466..18415480
-
Hg19::chr2:25195104..25195126,+p5@DNAJC27-AS1
Hg19::chr8:38243836..38243862,+p10@LETM2
Hg19::chr9:129485649..129485680,-p@chr9:129485649..129485680
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.30e-30136
nongranular leukocyte2.82e-25115
hematopoietic lineage restricted progenitor cell3.11e-25120
hematopoietic cell2.16e-23177
hematopoietic stem cell4.19e-23168
angioblastic mesenchymal cell4.19e-23168
mature alpha-beta T cell1.57e-2218
alpha-beta T cell1.57e-2218
immature T cell1.57e-2218
mature T cell1.57e-2218
immature alpha-beta T cell1.57e-2218
hematopoietic oligopotent progenitor cell4.99e-21161
hematopoietic multipotent progenitor cell4.99e-21161
T cell1.35e-1925
pro-T cell1.35e-1925
lymphoid lineage restricted progenitor cell4.44e-1952
intermediate monocyte6.55e-199
CD14-positive, CD16-positive monocyte6.55e-199
lymphocyte1.39e-1853
common lymphoid progenitor1.39e-1853
nucleate cell1.18e-1755
CD4-positive, alpha-beta T cell1.35e-146
CD8-positive, alpha-beta T cell4.56e-1211
myeloid leukocyte6.27e-1272
classical monocyte2.34e-1042
CD14-positive, CD16-negative classical monocyte2.34e-1042
circulating cell3.97e-096
myeloid lineage restricted progenitor cell9.73e-0966
defensive cell1.52e-0848
phagocyte1.52e-0848
granulocyte monocyte progenitor cell1.56e-0867
natural killer cell1.61e-083
pro-NK cell1.61e-083
naive T cell4.74e-083
histamine secreting cell7.07e-085
biogenic amine secreting cell7.07e-085
granulocytopoietic cell7.07e-085
mast cell7.07e-085
mast cell progenitor7.07e-085
basophil mast progenitor cell7.07e-085
basophil7.32e-083
single nucleate cell1.23e-073
mononuclear cell1.23e-073
non-classical monocyte2.38e-073
CD14-low, CD16-positive monocyte2.38e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.82e-1098
blood island1.82e-1098
hemolymphoid system7.68e-09108
bone marrow5.94e-0776


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187653.135722332310870.01024880501420960.0381486544614384
POLR2A#543082.147453176558070.002210725788971910.0127174877815718



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.