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Coexpression cluster:C3523

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Full id: C3523_leukemia_acute_chronic_Whole_Reticulocytes_lung_CD14



Phase1 CAGE Peaks

Hg19::chr15:81391699..81391704,+p6@C15orf26
Hg19::chr15:81391723..81391731,+p4@C15orf26
Hg19::chr15:81391740..81391757,+p1@C15orf26


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
blood9.02e-2715
haemolymphatic fluid9.02e-2715
organism substance9.02e-2715
adult organism1.37e-08114
Disease
Ontology termp-valuen
myeloid leukemia4.44e-3231
leukemia1.08e-2439
chronic leukemia1.60e-198
hematologic cancer5.73e-1851
immune system cancer5.73e-1851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189697150309713
CEBPB#105137.971147625824820.001974187055288560.0115089099563093
EGR1#195834.988179094810140.008056488137383440.0319940516590056
ELF1#199734.258097958807540.01295179875054610.0461285264530174
GABPB1#255337.067683836182170.002832212825417420.015389078366046
GATA1#2623313.56030814380040.0004009615963782630.00387489850690751
GATA2#2624312.7449317335540.0004829527704283790.00436551016018431
HDAC2#3066313.41562023662630.0004140761399857210.00390692004552974
REST#597839.650028716128020.001112636247114590.00766457469905683
STAT2#6773365.26377118644073.59360517547754e-060.000118208671156441
TAL1#6886329.86861667744023.75103522793067e-050.000719343312834835



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.