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Coexpression cluster:C4467

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Full id: C4467_Smooth_Fibroblast_Hepatocyte_pancreas_Mesenchymal_somatostatinoma_Adipocyte



Phase1 CAGE Peaks

Hg19::chr5:138533973..138534006,-p1@SIL1
Hg19::chr5:138534029..138534045,-p3@SIL1
Hg19::chr5:138534047..138534064,-p2@SIL1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
trunk mesenchyme2.46e-15143
trunk4.71e-15216
multilaminar epithelium2.13e-1282
dermomyotome3.18e-1270
somite5.82e-1283
paraxial mesoderm5.82e-1283
presomitic mesoderm5.82e-1283
presumptive segmental plate5.82e-1283
trunk paraxial mesoderm5.82e-1283
presumptive paraxial mesoderm5.82e-1283
skeletal muscle tissue1.26e-1161
striated muscle tissue1.26e-1161
myotome1.26e-1161
epithelial tube2.44e-11118
muscle tissue3.88e-1163
musculature3.88e-1163
musculature of body3.88e-1163
mesenchyme8.18e-11238
entire embryonic mesenchyme8.18e-11238
organism subdivision1.39e-10365
subdivision of trunk9.58e-10113
artery4.84e-0942
arterial blood vessel4.84e-0942
arterial system4.84e-0942
unilaminar epithelium5.36e-09138
multi-tissue structure1.28e-08347
mesoderm1.56e-08448
mesoderm-derived structure1.56e-08448
presumptive mesoderm1.56e-08448
splanchnic layer of lateral plate mesoderm1.74e-0884
multi-cellular organism1.81e-08659
vasculature1.92e-0879
vascular system1.92e-0879
systemic artery6.03e-0833
systemic arterial system6.03e-0833
vessel1.62e-0769
anatomical group1.62e-07626
abdominal segment of trunk2.19e-0761
abdomen2.19e-0761
blood vessel2.37e-0760
epithelial tube open at both ends2.37e-0760
blood vasculature2.37e-0760
vascular cord2.37e-0760
anatomical system2.43e-07625
epithelium5.83e-07309
cell layer7.12e-07312


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.