Coexpression cluster:C970

Full id: C970_acute_Mast_Reticulocytes_chronic_blood_leukemia_CD34

Phase1 CAGE Peaks

Hg19::chr10:119001440..119001449,-	p4@ENST00000425264
Hg19::chr15:50550090..50550094,-	p@chr15:50550090..50550094 -
Hg19::chr16:81528979..81528991,+	p19@CMIP
Hg19::chr1:47696918..47696935,-	p6@TAL1
Hg19::chr3:128135240..128135252,+	p@chr3:128135240..128135252 +
Hg19::chr3:128135271..128135297,+	p@chr3:128135271..128135297 +
Hg19::chr3:128205927..128205936,-	p3@AB463675
Hg19::chr5:179193683..179193691,+	p@chr5:179193683..179193691 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030218	erythrocyte differentiation	0.0362651595431532
GO:0045165	cell fate commitment	0.0362651595431532
GO:0030099	myeloid cell differentiation	0.0362651595431532
GO:0030097	hemopoiesis	0.0428588249146356
GO:0048534	hemopoietic or lymphoid organ development	0.0428588249146356
GO:0002520	immune system development	0.0428588249146356

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

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Cell Type

Ontology term	p-value	n
histamine secreting cell	5.31e-51	5
biogenic amine secreting cell	5.31e-51	5
granulocytopoietic cell	5.31e-51	5
mast cell	5.31e-51	5
mast cell progenitor	5.31e-51	5
basophil mast progenitor cell	5.31e-51	5
endocrine cell	2.28e-28	9
myeloid cell	5.06e-24	108
common myeloid progenitor	5.06e-24	108
hematopoietic oligopotent progenitor cell	2.39e-15	161
hematopoietic multipotent progenitor cell	2.39e-15	161
hematopoietic stem cell	1.32e-14	168
angioblastic mesenchymal cell	1.32e-14	168
hematopoietic cell	9.71e-14	177
secretory cell	5.25e-07	36

Disease

Ontology term	p-value	n
chronic leukemia	7.96e-59	8
myeloid leukemia	4.93e-44	31
leukemia	1.16e-34	39
hematologic cancer	4.17e-26	51
immune system cancer	4.17e-26	51
chronic myeloid leukemia	1.60e-11	1
acute myeloid leukemia	2.18e-11	1
organ system cancer	1.66e-08	137

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ELK4#2005	3	6.08838062192551	0.0103437704184363	0.0384158827470954
GATA2#2624	4	6.372465866777	0.00204874075705145	0.0118957266873685
MAFK#7975	3	10.1627749266862	0.00244557310713952	0.0137696484843681
SUZ12#23512	2	12.5289452277657	0.0102887917029838	0.0382239298757799
TAL1#6886	5	18.6678854234001	2.16085962597693e-06	7.81704255204036e-05
ZBTB7A#51341	5	4.59494331742243	0.00181943519354047	0.0109012674073876

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.