MCL coexpression mm9:1086

Phase1 CAGE Peaks

	Short description
Mm9::chr11:69779098..69779123,+	p4@Cldn7
Mm9::chr12:77896412..77896451,-	p1@Gpx2
Mm9::chr12:77896458..77896465,-	p3@Gpx2
Mm9::chr12:77896476..77896508,-	p2@Gpx2
Mm9::chr5:31554051..31554101,+	p1@Krtcap3
Mm9::chr5:31554116..31554131,+	p2@Krtcap3
Mm9::chr5:31554284..31554295,+	p3@Krtcap3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004602	glutathione peroxidase activity	0.037899835520948
GO:0008430	selenium binding	0.037899835520948
GO:0004601	peroxidase activity	0.037899835520948
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	0.037899835520948
GO:0006979	response to oxidative stress	0.0413180817439719

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	2.56e-08	9
epithelial cell of alimentary canal	2.56e-08	9
epithelial cell	6.06e-08	25
endo-epithelial cell	1.36e-07	15

Uber Anatomy

Ontology term	p-value	n
intestine	5.63e-23	31
gastrointestinal system	6.53e-23	47
digestive system	5.09e-16	116
digestive tract	5.09e-16	116
primitive gut	5.09e-16	116
endoderm-derived structure	6.80e-16	118
endoderm	6.80e-16	118
presumptive endoderm	6.80e-16	118
subdivision of digestive tract	1.03e-14	114
mucosa	3.66e-13	15
intestinal mucosa	1.75e-11	13
anatomical wall	1.75e-11	13
wall of intestine	1.75e-11	13
gastrointestinal system mucosa	1.75e-11	13
simple columnar epithelium	8.26e-09	11
thoracic cavity element	1.45e-08	17
thoracic segment organ	1.45e-08	17
thoracic cavity	1.45e-08	17
thoracic segment of trunk	1.45e-08	17
respiratory primordium	1.45e-08	17
endoderm of foregut	1.45e-08	17
epithelium of mucosa	2.56e-08	9
gastrointestinal system epithelium	2.56e-08	9
intestinal epithelium	2.56e-08	9
organ component layer	3.55e-07	24
epithelial bud	4.20e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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