MCL coexpression mm9:64
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0006793 | phosphorus metabolic process | 0.00278044920095333 |
| GO:0006796 | phosphate metabolic process | 0.00278044920095333 |
| GO:0000166 | nucleotide binding | 0.00278044920095333 |
| GO:0032555 | purine ribonucleotide binding | 0.00278044920095333 |
| GO:0032553 | ribonucleotide binding | 0.00278044920095333 |
| GO:0017076 | purine nucleotide binding | 0.00368169664019364 |
| GO:0043283 | biopolymer metabolic process | 0.00716610501837858 |
| GO:0016310 | phosphorylation | 0.00883445904346457 |
| GO:0005524 | ATP binding | 0.0108904151118522 |
| GO:0043687 | post-translational protein modification | 0.0108904151118522 |
| GO:0032559 | adenyl ribonucleotide binding | 0.0108904151118522 |
| GO:0030554 | adenyl nucleotide binding | 0.0157073919173566 |
| GO:0000922 | spindle pole | 0.016627503658916 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.0272645472091043 |
| GO:0043170 | macromolecule metabolic process | 0.0272645472091043 |
| GO:0006464 | protein modification process | 0.0272645472091043 |
| GO:0043412 | biopolymer modification | 0.0358960328264356 |
| GO:0004674 | protein serine/threonine kinase activity | 0.0463960237421549 |
| GO:0002260 | lymphocyte homeostasis | 0.0499635108981098 |
| GO:0044237 | cellular metabolic process | 0.0499635108981098 |
| GO:0006468 | protein amino acid phosphorylation | 0.0499635108981098 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| stem cell | 1.15e-16 | 97 |
| somatic stem cell | 2.04e-15 | 91 |
| multi fate stem cell | 2.04e-15 | 91 |
| animal cell | 2.50e-14 | 115 |
| eukaryotic cell | 2.50e-14 | 115 |
| somatic cell | 8.39e-14 | 118 |
| neuron | 3.09e-13 | 33 |
| neuronal stem cell | 3.09e-13 | 33 |
| neuroblast | 3.09e-13 | 33 |
| electrically signaling cell | 3.09e-13 | 33 |
| neural cell | 1.29e-12 | 43 |
| autonomic neuron | 2.99e-12 | 9 |
| ectodermal cell | 3.02e-12 | 44 |
| neurectodermal cell | 3.02e-12 | 44 |
| electrically responsive cell | 1.03e-10 | 39 |
| electrically active cell | 1.03e-10 | 39 |
| non-terminally differentiated cell | 1.27e-10 | 49 |
| erythroid lineage cell | 7.05e-09 | 3 |
| erythroblast | 7.05e-09 | 3 |
| erythroid progenitor cell | 7.05e-09 | 3 |
| proerythroblast | 7.05e-09 | 3 |
| myeloid lineage restricted progenitor cell | 7.84e-09 | 13 |
| embryonic cell | 1.78e-08 | 70 |
| hematopoietic lineage restricted progenitor cell | 4.43e-08 | 25 |
| myeloid cell | 5.44e-07 | 16 |
| megakaryocyte-erythroid progenitor cell | 5.86e-07 | 9 |
| Ontology term | p-value | n |
|---|---|---|
| autonomic nervous system | 2.99e-12 | 9 |
| peripheral nervous system | 7.39e-10 | 11 |
| neural crest-derived structure | 6.58e-08 | 3 |
| neural crest | 6.58e-08 | 3 |
| enteric nervous system | 6.58e-08 | 3 |
| vagal neural crest | 6.58e-08 | 3 |
| neural fold | 6.58e-08 | 3 |
| parasympathetic nervous system | 1.71e-07 | 3 |
| central nervous system | 7.94e-07 | 73 |
| Ontology term | p-value | n |
|---|---|---|
| hematologic cancer | 7.05e-09 | 3 |
| immune system cancer | 7.05e-09 | 3 |
| leukemia | 7.05e-09 | 3 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.000529079 |
| MA0004.1 | 0.337416 |
| MA0006.1 | 0.392102 |
| MA0007.1 | 0.199264 |
| MA0009.1 | 0.0456175 |
| MA0014.1 | 0.0280141 |
| MA0017.1 | 0.575008 |
| MA0019.1 | 1.01765 |
| MA0024.1 | 0.568291 |
| MA0025.1 | 0.421429 |
| MA0027.1 | 1.10516 |
| MA0028.1 | 1.12937 |
| MA0029.1 | 0.172844 |
| MA0030.1 | 0.328249 |
| MA0031.1 | 0.429485 |
| MA0038.1 | 0.881484 |
| MA0040.1 | 0.743016 |
| MA0041.1 | 1.83457 |
| MA0042.1 | 0.589403 |
| MA0043.1 | 0.227517 |
| MA0046.1 | 0.321618 |
| MA0048.1 | 0.00410059 |
| MA0050.1 | 0.178533 |
| MA0051.1 | 1.44303 |
| MA0052.1 | 0.504703 |
| MA0055.1 | 1.47104e-05 |
| MA0056.1 | 0 |
| MA0057.1 | 7.80767e-05 |
| MA0058.1 | 0.247397 |
| MA0059.1 | 0.295411 |
| MA0060.1 | 0.960199 |
| MA0061.1 | 0.0130929 |
| MA0063.1 | 0 |
| MA0066.1 | 0.0702137 |
| MA0067.1 | 0.297269 |
| MA0068.1 | 0.0390626 |
| MA0069.1 | 1.86516 |
| MA0070.1 | 1.04741 |
| MA0071.1 | 0.176709 |
| MA0072.1 | 0.0466367 |
| MA0073.1 | 4.30099e-07 |
| MA0074.1 | 0.0835301 |
| MA0076.1 | 0.728693 |
| MA0077.1 | 0.412388 |
| MA0078.1 | 0.67638 |
| MA0081.1 | 0.29995 |
| MA0083.1 | 0.0905221 |
| MA0084.1 | 0.733105 |
| MA0087.1 | 0.35113 |
| MA0088.1 | 0.0214995 |
| MA0089.1 | 0 |
| MA0090.1 | 0.0604845 |
| MA0091.1 | 0.666566 |
| MA0092.1 | 0.0996507 |
| MA0093.1 | 0.325046 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.0364522 |
| MA0101.1 | 0.120544 |
| MA0103.1 | 0.0604134 |
| MA0105.1 | 3.24767e-05 |
| MA0106.1 | 0.137612 |
| MA0107.1 | 0.0811586 |
| MA0108.2 | 0.280346 |
| MA0109.1 | 0 |
| MA0111.1 | 0.364443 |
| MA0113.1 | 0.051541 |
| MA0114.1 | 0.0724874 |
| MA0115.1 | 0.71447 |
| MA0116.1 | 0.00697585 |
| MA0117.1 | 0.193583 |
| MA0119.1 | 0.00666893 |
| MA0122.1 | 0.216114 |
| MA0124.1 | 1.85776 |
| MA0125.1 | 0.175417 |
| MA0130.1 | 0 |
| MA0131.1 | 0.364106 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.508454 |
| MA0136.1 | 0.179316 |
| MA0139.1 | 0.0216782 |
| MA0140.1 | 0.747668 |
| MA0141.1 | 0.260565 |
| MA0142.1 | 0.836502 |
| MA0143.1 | 0.327593 |
| MA0144.1 | 0.0540792 |
| MA0145.1 | 0.00198102 |
| MA0146.1 | 0.000131072 |
| MA0147.1 | 0.258564 |
| MA0148.1 | 1.26668 |
| MA0149.1 | 8.96287 |
| MA0062.2 | 1.22883 |
| MA0035.2 | 0.442318 |
| MA0039.2 | 0.00328646 |
| MA0138.2 | 0.510766 |
| MA0002.2 | 0.074558 |
| MA0137.2 | 0.0862568 |
| MA0104.2 | 0.315328 |
| MA0047.2 | 0.497685 |
| MA0112.2 | 0.00073081 |
| MA0065.2 | 0.00205346 |
| MA0150.1 | 0.0836883 |
| MA0151.1 | 0 |
| MA0152.1 | 0.233374 |
| MA0153.1 | 0.29589 |
| MA0154.1 | 0.000375226 |
| MA0155.1 | 0.0522596 |
| MA0156.1 | 0.0446889 |
| MA0157.1 | 0.186924 |
| MA0158.1 | 0 |
| MA0159.1 | 0.00965168 |
| MA0160.1 | 0.0855515 |
| MA0161.1 | 0 |
| MA0162.1 | 0.000444922 |
| MA0163.1 | 0.000215173 |
| MA0164.1 | 0.402854 |
| MA0080.2 | 0.0188522 |
| MA0018.2 | 0.120018 |
| MA0099.2 | 0.0523238 |
| MA0079.2 | 6.99322e-11 |
| MA0102.2 | 0.301415 |
| MA0258.1 | 0.0487384 |
| MA0259.1 | 0.420343 |
| MA0442.1 | 0 |
