MCL coexpression mm9:207
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0044444 | cytoplasmic part | 0.000282243637853724 |
| GO:0007031 | peroxisome organization and biogenesis | 0.00183289316085539 |
| GO:0042579 | microbody | 0.00200000199872482 |
| GO:0005777 | peroxisome | 0.00200000199872482 |
| GO:0006625 | protein targeting to peroxisome | 0.00200000199872482 |
| GO:0043574 | peroxisomal transport | 0.00200000199872482 |
| GO:0044255 | cellular lipid metabolic process | 0.00200000199872482 |
| GO:0005737 | cytoplasm | 0.00318840177491466 |
| GO:0006629 | lipid metabolic process | 0.00376957316519926 |
| GO:0005048 | signal sequence binding | 0.00496645216233344 |
| GO:0019752 | carboxylic acid metabolic process | 0.0054597016437832 |
| GO:0006082 | organic acid metabolic process | 0.0054597016437832 |
| GO:0030301 | cholesterol transport | 0.00960073583010757 |
| GO:0015918 | sterol transport | 0.0102744941563769 |
| GO:0006644 | phospholipid metabolic process | 0.0265275240536747 |
| GO:0005783 | endoplasmic reticulum | 0.0265275240536747 |
| GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity | 0.0265275240536747 |
| GO:0017001 | antibiotic catabolic process | 0.0265275240536747 |
| GO:0015093 | ferrous iron transmembrane transporter activity | 0.0265275240536747 |
| GO:0008800 | beta-lactamase activity | 0.0265275240536747 |
| GO:0030655 | beta-lactam antibiotic catabolic process | 0.0265275240536747 |
| GO:0051748 | UDP-sugar pyrophosphorylase activity | 0.0265275240536747 |
| GO:0016804 | prolyl aminopeptidase activity | 0.0265275240536747 |
| GO:0018114 | threonine racemase activity | 0.0265275240536747 |
| GO:0004042 | amino-acid N-acetyltransferase activity | 0.0265275240536747 |
| GO:0004306 | ethanolamine-phosphate cytidylyltransferase activity | 0.0265275240536747 |
| GO:0030653 | beta-lactam antibiotic metabolic process | 0.0265275240536747 |
| GO:0030378 | serine racemase activity | 0.0265275240536747 |
| GO:0003991 | acetylglutamate kinase activity | 0.0265275240536747 |
| GO:0006643 | membrane lipid metabolic process | 0.0366001306615916 |
| GO:0009308 | amine metabolic process | 0.0366001306615916 |
| GO:0006631 | fatty acid metabolic process | 0.0366001306615916 |
| GO:0030170 | pyridoxal phosphate binding | 0.0366001306615916 |
| GO:0016740 | transferase activity | 0.0366001306615916 |
| GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | 0.0366001306615916 |
| GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity | 0.0366001306615916 |
| GO:0000268 | peroxisome targeting sequence binding | 0.0366001306615916 |
| GO:0003986 | acetyl-CoA hydrolase activity | 0.0366001306615916 |
| GO:0006642 | triacylglycerol mobilization | 0.0366001306615916 |
| GO:0016580 | Sin3 complex | 0.0366001306615916 |
| GO:0005046 | KDEL sequence binding | 0.0366001306615916 |
| GO:0004795 | threonine synthase activity | 0.0366001306615916 |
| GO:0000287 | magnesium ion binding | 0.0375876114898993 |
| GO:0006807 | nitrogen compound metabolic process | 0.0378655569561019 |
| GO:0008654 | phospholipid biosynthetic process | 0.0434664964039327 |
| GO:0008035 | high-density lipoprotein binding | 0.0434664964039327 |
| GO:0043534 | blood vessel endothelial cell migration | 0.0434664964039327 |
| GO:0004427 | inorganic diphosphatase activity | 0.0434664964039327 |
| GO:0016838 | carbon-oxygen lyase activity, acting on phosphates | 0.0434664964039327 |
| GO:0016855 | racemase and epimerase activity, acting on amino acids and derivatives | 0.0434664964039327 |
| GO:0046923 | ER retention sequence binding | 0.0434664964039327 |
| GO:0016558 | protein import into peroxisome matrix | 0.0434664964039327 |
| GO:0006621 | protein retention in ER | 0.0434664964039327 |
| GO:0032787 | monocarboxylic acid metabolic process | 0.0438408156713767 |
| GO:0006520 | amino acid metabolic process | 0.0438408156713767 |
| GO:0005779 | integral to peroxisomal membrane | 0.0438408156713767 |
| GO:0042826 | histone deacetylase binding | 0.0438408156713767 |
| GO:0004178 | leucyl aminopeptidase activity | 0.0438408156713767 |
| GO:0007029 | endoplasmic reticulum organization and biogenesis | 0.0438408156713767 |
| GO:0002483 | antigen processing and presentation of endogenous peptide antigen | 0.0438408156713767 |
| GO:0016999 | antibiotic metabolic process | 0.0438408156713767 |
| GO:0033344 | cholesterol efflux | 0.0438408156713767 |
| GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | 0.0438408156713767 |
| GO:0005381 | iron ion transmembrane transporter activity | 0.0438408156713767 |
| GO:0016774 | phosphotransferase activity, carboxyl group as acceptor | 0.0438408156713767 |
| GO:0019883 | antigen processing and presentation of endogenous antigen | 0.0438408156713767 |
| GO:0030300 | regulation of cholesterol absorption | 0.0438408156713767 |
| GO:0006536 | glutamate metabolic process | 0.0438408156713767 |
| GO:0021795 | cerebral cortex cell migration | 0.0438408156713767 |
| GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I | 0.0438408156713767 |
| GO:0046467 | membrane lipid biosynthetic process | 0.0461504408627579 |
| GO:0006869 | lipid transport | 0.0479796696453757 |
| GO:0030299 | cholesterol absorption | 0.0491359779614124 |
| GO:0051346 | negative regulation of hydrolase activity | 0.0491359779614124 |
| GO:0031231 | intrinsic to peroxisomal membrane | 0.0491359779614124 |
| GO:0006526 | arginine biosynthetic process | 0.0491359779614124 |
| GO:0044241 | lipid digestion | 0.0491359779614124 |
| GO:0017144 | drug metabolic process | 0.0491359779614124 |
| GO:0008610 | lipid biosynthetic process | 0.0496872908318591 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 4.52195 |
| MA0004.1 | 0.607845 |
| MA0006.1 | 0.873758 |
| MA0007.1 | 0.896243 |
| MA0009.1 | 0.260251 |
| MA0014.1 | 5.18355 |
| MA0017.1 | 1.75348 |
| MA0019.1 | 0.144464 |
| MA0024.1 | 0.230104 |
| MA0025.1 | 0.439705 |
| MA0027.1 | 1.78014 |
| MA0028.1 | 2.04036 |
| MA0029.1 | 0.215644 |
| MA0030.1 | 0.219976 |
| MA0031.1 | 0.196896 |
| MA0038.1 | 0.619614 |
| MA0040.1 | 0.269109 |
| MA0041.1 | 0.413962 |
| MA0042.1 | 0.383143 |
| MA0043.1 | 0.331198 |
| MA0046.1 | 0.285948 |
| MA0048.1 | 0.610228 |
| MA0050.1 | 0.405933 |
| MA0051.1 | 1.0663 |
| MA0052.1 | 0.754658 |
| MA0055.1 | 1.43503 |
| MA0056.1 | 0 |
| MA0057.1 | 0.699569 |
| MA0058.1 | 1.2692 |
| MA0059.1 | 1.33889 |
| MA0060.1 | 0.495935 |
| MA0061.1 | 0.628571 |
| MA0063.1 | 0 |
| MA0066.1 | 1.00294 |
| MA0067.1 | 0.533552 |
| MA0068.1 | 1.17122 |
| MA0069.1 | 0.27511 |
| MA0070.1 | 0.268186 |
| MA0071.1 | 0.0477117 |
| MA0072.1 | 0.262182 |
| MA0073.1 | 4.81869 |
| MA0074.1 | 0.521239 |
| MA0076.1 | 2.36195 |
| MA0077.1 | 0.247052 |
| MA0078.1 | 0.350644 |
| MA0081.1 | 0.0961027 |
| MA0083.1 | 0.330594 |
| MA0084.1 | 0.829882 |
| MA0087.1 | 0.29831 |
| MA0088.1 | 2.68839 |
| MA0089.1 | 0 |
| MA0090.1 | 0.0277515 |
| MA0091.1 | 0.0401384 |
| MA0092.1 | 0.0278248 |
| MA0093.1 | 0.970722 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.856308 |
| MA0101.1 | 0.417038 |
| MA0103.1 | 0.289464 |
| MA0105.1 | 0.347738 |
| MA0106.1 | 1.75226 |
| MA0107.1 | 0.135076 |
| MA0108.2 | 0.47642 |
| MA0109.1 | 0 |
| MA0111.1 | 0.127353 |
| MA0113.1 | 0.324571 |
| MA0114.1 | 3.13791 |
| MA0115.1 | 2.41412 |
| MA0116.1 | 0.101542 |
| MA0117.1 | 0.832079 |
| MA0119.1 | 0.08658 |
| MA0122.1 | 0.323899 |
| MA0124.1 | 0.488052 |
| MA0125.1 | 0.426393 |
| MA0130.1 | 0 |
| MA0131.1 | 0.861085 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.359267 |
| MA0136.1 | 0.0770147 |
| MA0139.1 | 1.94424 |
| MA0140.1 | 0.230166 |
| MA0141.1 | 0.557067 |
| MA0142.1 | 0.187772 |
| MA0143.1 | 0.702938 |
| MA0144.1 | 0.256406 |
| MA0145.1 | 0.59448 |
| MA0146.1 | 2.75597 |
| MA0147.1 | 1.26867 |
| MA0148.1 | 1.44323 |
| MA0149.1 | 0.0899707 |
| MA0062.2 | 2.52012 |
| MA0035.2 | 0.235339 |
| MA0039.2 | 5.92286 |
| MA0138.2 | 0.137563 |
| MA0002.2 | 0.381211 |
| MA0137.2 | 0.162668 |
| MA0104.2 | 1.44714 |
| MA0047.2 | 0.296989 |
| MA0112.2 | 1.95262 |
| MA0065.2 | 1.1806 |
| MA0150.1 | 0.31023 |
| MA0151.1 | 0 |
| MA0152.1 | 1.03565 |
| MA0153.1 | 0.972944 |
| MA0154.1 | 0.995578 |
| MA0155.1 | 1.93422 |
| MA0156.1 | 0.304965 |
| MA0157.1 | 0.168226 |
| MA0158.1 | 0 |
| MA0159.1 | 0.311625 |
| MA0160.1 | 1.02652 |
| MA0161.1 | 0 |
| MA0162.1 | 1.66056 |
| MA0163.1 | 2.67736 |
| MA0164.1 | 0.26624 |
| MA0080.2 | 0.00983331 |
| MA0018.2 | 0.0812385 |
| MA0099.2 | 0.134134 |
| MA0079.2 | 8.15079 |
| MA0102.2 | 0.879116 |
| MA0258.1 | 2.09708 |
| MA0259.1 | 0.639291 |
| MA0442.1 | 0 |
