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Coexpression cluster:C1835

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Full id: C1835_CD14_Mast_Natural_Eosinophils_Peripheral_immature_Basophils



Phase1 CAGE Peaks

Hg19::chr1:150583933..150583944,-p@chr1:150583933..150583944
-
Hg19::chr1:150584006..150584024,-p1@AK129725
Hg19::chr1:150584301..150584312,+p@chr1:150584301..150584312
+
Hg19::chr1:150584909..150584912,+p@chr1:150584909..150584912
+
Hg19::chr1:204381399..204381426,+p@chr1:204381399..204381426
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte4.07e-33140
CD14-positive, CD16-negative classical monocyte4.83e-3142
hematopoietic stem cell1.02e-27172
angioblastic mesenchymal cell1.02e-27172
classical monocyte2.23e-2745
hematopoietic oligopotent progenitor cell7.28e-25165
hematopoietic multipotent progenitor cell7.28e-25165
myeloid leukocyte3.33e-2476
hematopoietic cell3.76e-24182
nongranular leukocyte5.41e-24119
hematopoietic lineage restricted progenitor cell7.36e-24124
granulocyte monocyte progenitor cell1.68e-2071
macrophage dendritic cell progenitor2.82e-1965
myeloid cell4.35e-19112
common myeloid progenitor4.35e-19112
monopoietic cell5.07e-1863
monocyte5.07e-1863
monoblast5.07e-1863
promonocyte5.07e-1863
myeloid lineage restricted progenitor cell1.31e-1770
mesenchymal cell1.83e-11358
connective tissue cell2.27e-11365
intermediate monocyte1.02e-079
CD14-positive, CD16-positive monocyte1.02e-079
multi fate stem cell1.05e-07430
stem cell1.27e-07444
motile cell1.28e-07390
granulocyte1.32e-078
somatic stem cell2.69e-07436
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.49e-24102
blood island1.49e-24102
hemolymphoid system1.87e-21112
bone marrow1.25e-1880
bone element3.81e-1786
immune system5.15e-15115
skeletal element7.67e-14101
skeletal system7.67e-14101
connective tissue1.03e-10375
lateral plate mesoderm5.79e-08216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.