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Coexpression cluster:C2654

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Full id: C2654_Chondrocyte_Renal_Fibroblast_Anulus_sacrococcigeal_Smooth_Osteoblast



Phase1 CAGE Peaks

Hg19::chr2:106015446..106015457,-p4@FHL2
Hg19::chr2:106015472..106015488,-p2@FHL2
Hg19::chr2:106015491..106015518,-p1@FHL2
Hg19::chr2:106015527..106015538,-p6@FHL2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
trunk mesenchyme4.32e-20143
trunk1.31e-18216
somite1.44e-1783
paraxial mesoderm1.44e-1783
presomitic mesoderm1.44e-1783
presumptive segmental plate1.44e-1783
trunk paraxial mesoderm1.44e-1783
presumptive paraxial mesoderm1.44e-1783
vasculature4.06e-1779
vascular system4.06e-1779
mesenchyme6.95e-17238
entire embryonic mesenchyme6.95e-17238
multilaminar epithelium8.54e-1682
epithelial tube1.58e-15118
dermomyotome3.95e-1570
organism subdivision8.45e-15365
skeletal muscle tissue9.17e-1561
striated muscle tissue9.17e-1561
myotome9.17e-1561
muscle tissue1.64e-1463
musculature1.64e-1463
musculature of body1.64e-1463
unilaminar epithelium2.01e-14138
multi-tissue structure2.03e-14347
splanchnic layer of lateral plate mesoderm2.64e-1384
blood vessel2.79e-1360
epithelial tube open at both ends2.79e-1360
blood vasculature2.79e-1360
vascular cord2.79e-1360
artery6.95e-1342
arterial blood vessel6.95e-1342
arterial system6.95e-1342
vessel1.07e-1269
cell layer7.86e-11312
multi-cellular organism1.08e-10659
cardiovascular system1.27e-10110
systemic artery2.01e-1033
systemic arterial system2.01e-1033
epithelium3.83e-10309
circulatory system5.38e-10113
surface structure2.80e-0995
anatomical cluster5.11e-09286
anatomical system1.98e-08625
anatomical group3.07e-08626
body cavity precursor9.43e-0863
mesoderm1.02e-07448
mesoderm-derived structure1.02e-07448
presumptive mesoderm1.02e-07448
intermediate mesoderm7.84e-0737


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00512738917473854
CTCF#1066445.360256373075030.001211145381643620.0081812827445494
CTCFL#140690419.74647435897446.5732084880439e-060.000193162442679464
E2F1#186944.907389214879320.001724022357361790.0106604600935765
E2F4#1874412.66806031528443.88145892637771e-050.000727653363510971
E2F6#187645.017155731697390.00157802193473060.00997802463167215
ELF1#199744.258097958807540.003041525565781240.0161073925543647
ELK4#2005416.2356816584681.43847748454449e-050.000343468564262327
EP300#203346.77394172622320.0004748459821442640.00434525887401777
HEY1#2346244.040111043105710.00375304636917980.0186321438299553
HMGN3#932448.178547723350590.0002234570284440470.00248325479821961
JUND#372746.994663941871030.000417684217818580.00392042078051179
MAFF#23764228.15767824497260.001846876180367150.0109265224835079
NANOG#79923429.24477848101271.36586687657858e-065.34268804205957e-05
NRF1#4899412.21027944771094.49717228915276e-050.000794452261006132
PAX5#507946.669565531177830.0005052774169483260.004443471551757
RAD21#5885410.35503389545638.6948481184721e-050.00129559315543602
SETDB1#9869440.32002617801053.77887289069054e-071.85200237367822e-05
SRF#6722413.79717826216782.75840773062708e-050.000585063657552724
TAF1#687243.343046285745290.008005664898701650.0322682890029525
TAF7#6879411.43306940492395.85061525419808e-050.00097050890491295
TBP#690843.706770687096390.005296377814784350.0244582774406731
ZBTB7A#5134147.35190930787590.000342223540015990.00346937335427392
ZNF263#1012736.166381227758010.006539814347975980.0279796678009202



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.