Coexpression cluster:C155

Full id: C155_pituitary_placenta_nonsmall_cervical_smallcell_choriocarcinoma_epitheloid

Phase1 CAGE Peaks

Hg19::chr10:124615386..124615429,-	p@chr10:124615386..124615429 -
Hg19::chr11:30252514..30252529,+	p4@FSHB
Hg19::chr11:30252549..30252565,+	p1@FSHB
Hg19::chr11:46295968..46295985,-	p1@ENST00000527239
Hg19::chr11:70178863..70178874,+	p@chr11:70178863..70178874 +
Hg19::chr12:7341800..7341812,+	p5@PEX5
Hg19::chr13:78813679..78813681,-	p@chr13:78813679..78813681 -
Hg19::chr14:101193418..101193423,+	p8@DLK1
Hg19::chr16:60564560..60564561,+	p@chr16:60564560..60564561 +
Hg19::chr17:18012035..18012048,+	p2@MYO15A
Hg19::chr17:185919..185925,-	p@chr17:185919..185925 -
Hg19::chr17:26877299..26877303,+	p@chr17:26877299..26877303 +
Hg19::chr17:61973929..61973936,-	p3@CSH1
Hg19::chr17:61994613..61994649,-	p@chr17:61994613..61994649 -
Hg19::chr17:61994760..61994767,+	p@chr17:61994760..61994767 +
Hg19::chr17:61994797..61994839,-	p@chr17:61994797..61994839 -
Hg19::chr17:61995172..61995199,-	p@chr17:61995172..61995199 -
Hg19::chr17:61995207..61995219,-	p@chr17:61995207..61995219 -
Hg19::chr17:61995220..61995244,-	p@chr17:61995220..61995244 -
Hg19::chr17:61995371..61995384,+	p@chr17:61995371..61995384 +
Hg19::chr17:61995410..61995414,-	p@chr17:61995410..61995414 -
Hg19::chr17:61995432..61995458,-	p@chr17:61995432..61995458 -
Hg19::chr17:61995480..61995499,-	p@chr17:61995480..61995499 -
Hg19::chr17:61995704..61995739,+	p@chr17:61995704..61995739 +
Hg19::chr17:61995740..61995772,-	p1@AB591020
Hg19::chr17:61996192..61996199,-	p1@GH1 p2@CSHL1
Hg19::chr17:76919498..76919500,+	p@chr17:76919498..76919500 +
Hg19::chr18:13915530..13915540,-	p1@MC2R
Hg19::chr19:4769143..4769147,+	p1@MIR7-3HG
Hg19::chr19:4772190..4772197,+	p@chr19:4772190..4772197 +
Hg19::chr19:49519347..49519354,-	p3@CU678753
Hg19::chr19:49519357..49519372,-	p1@CU678753
Hg19::chr19:49519519..49519562,-	p2@CU678753
Hg19::chr19:49519930..49519937,-	p@chr19:49519930..49519937 -
Hg19::chr19:49520344..49520367,-	p1@LHB
Hg19::chr19:49547457..49547458,+	p2@CGB5
Hg19::chr19:7979644..7979653,+	p@chr19:7979644..7979653 +
Hg19::chr19:7979665..7979675,+	p@chr19:7979665..7979675 +
Hg19::chr19:7979677..7979703,+	p@chr19:7979677..7979703 +
Hg19::chr19:7979708..7979734,+	p@chr19:7979708..7979734 +
Hg19::chr1:115572444..115572451,+	p1@TSHB
Hg19::chr1:151696600..151696645,+	p@chr1:151696600..151696645 +
Hg19::chr1:19435681..19435684,+	p@chr1:19435681..19435684 +
Hg19::chr1:2036352..2036358,-	p@chr1:2036352..2036358 -
Hg19::chr1:233598660..233598662,-	p@chr1:233598660..233598662 -
Hg19::chr1:240043364..240043366,+	p@chr1:240043364..240043366 +
Hg19::chr1:65990750..65990756,+	p@chr1:65990750..65990756 +
Hg19::chr20:19714764..19714765,+	p@chr20:19714764..19714765 +
Hg19::chr20:33567825..33567827,-	p@chr20:33567825..33567827 -
Hg19::chr20:36511296..36511298,+	p@chr20:36511296..36511298 +
Hg19::chr20:5903139..5903148,+	p@chr20:5903139..5903148 +
Hg19::chr20:5903320..5903383,-	p@chr20:5903320..5903383 -
Hg19::chr22:19373363..19373368,+	p@chr22:19373363..19373368 +
Hg19::chr22:47126639..47126654,+	p@chr22:47126639..47126654 +
Hg19::chr2:175434561..175434564,+	p@chr2:175434561..175434564 +
Hg19::chr2:193063406..193063411,-	p@chr2:193063406..193063411 -
Hg19::chr2:241080069..241080082,-	p1@OTOS
Hg19::chr2:863855..863859,-	p2@ENST00000415700 p2@uc002qwn.1 p2@uc002qwo.1
Hg19::chr2:863883..863897,-	p1@ENST00000415700 p1@uc002qwn.1 p1@uc002qwo.1
Hg19::chr3:187654553..187654555,+	p@chr3:187654553..187654555 +
Hg19::chr3:53894448..53894449,+	p@chr3:53894448..53894449 +
Hg19::chr3:56445982..56445989,+	p@chr3:56445982..56445989 +
Hg19::chr4:166300084..166300091,+	p8@CPE
Hg19::chr4:68620100..68620112,-	p1@GNRHR
Hg19::chr5:462101..462128,+	p8@EXOC3
Hg19::chr5:79375654..79375674,+	p@chr5:79375654..79375674 +
Hg19::chr5:79375715..79375734,+	p@chr5:79375715..79375734 +
Hg19::chr5:79375755..79375801,+	p@chr5:79375755..79375801 +
Hg19::chr6:22287647..22287662,-	p@chr6:22287647..22287662 -
Hg19::chr6:22287710..22287718,-	p@chr6:22287710..22287718 -
Hg19::chr6:22287720..22287725,-	p@chr6:22287720..22287725 -
Hg19::chr6:22287728..22287735,-	p@chr6:22287728..22287735 -
Hg19::chr6:22287747..22287758,-	p@chr6:22287747..22287758 -
Hg19::chr6:22287768..22287781,-	p@chr6:22287768..22287781 -
Hg19::chr6:22287787..22287798,-	p@chr6:22287787..22287798 -
Hg19::chr6:22287815..22287820,-	p@chr6:22287815..22287820 -
Hg19::chr6:22290440..22290455,+	p@chr6:22290440..22290455 +
Hg19::chr6:22290447..22290450,-	p@chr6:22290447..22290450 -
Hg19::chr6:22290473..22290492,-	p@chr6:22290473..22290492 -
Hg19::chr6:22290492..22290497,+	p@chr6:22290492..22290497 +
Hg19::chr6:22290499..22290506,+	p@chr6:22290499..22290506 +
Hg19::chr6:22292805..22292814,-	p@chr6:22292805..22292814 -
Hg19::chr6:22292828..22292837,-	p@chr6:22292828..22292837 -
Hg19::chr6:22292841..22292854,-	p@chr6:22292841..22292854 -
Hg19::chr6:22294671..22294709,-	p2@PRL
Hg19::chr6:22294718..22294725,-	p11@PRL
Hg19::chr6:22294730..22294743,-	p6@PRL
Hg19::chr6:22294755..22294768,-	p9@PRL
Hg19::chr6:22294783..22294799,-	p5@PRL
Hg19::chr6:22294803..22294830,-	p7@PRL
Hg19::chr6:31744574..31744603,-	p4@VWA7
Hg19::chr6:74072975..74072976,-	p@chr6:74072975..74072976 -
Hg19::chr6:87795324..87795331,-	p@chr6:87795324..87795331 -
Hg19::chr6:87795365..87795378,-	p@chr6:87795365..87795378 -
Hg19::chr6:87804815..87804830,-	p1@CGA
Hg19::chr7:116689..116690,+	p@chr7:116689..116690 +
Hg19::chr7:130010774..130010781,-	p@chr7:130010774..130010781 -
Hg19::chr7:31003593..31003614,+	p2@GHRHR
Hg19::chr7:31003621..31003641,+	p3@GHRHR
Hg19::chr7:31006831..31006834,+	p@chr7:31006831..31006834 +
Hg19::chr8:112641680..112641681,+	p@chr8:112641680..112641681 +
Hg19::chr8:126582844..126582849,-	p@chr8:126582844..126582849 -
Hg19::chr8:143411767..143411777,+	p@chr8:143411767..143411777 +
Hg19::chr9:75733141..75733143,+	p@chr9:75733141..75733143 +
Hg19::chr9:92757667..92757670,+	p@chr9:92757667..92757670 +
Hg19::chrX:103145056..103145060,+	p@chrX:103145056..103145060 +
Hg19::chrX:130215564..130215579,+	p@chrX:130215564..130215579 +
Hg19::chrX:130423225..130423228,-	p5@IGSF1
Hg19::chrX:45029527..45029529,-	p@chrX:45029527..45029529 -
Hg19::chrX:48689717..48689744,-	p@chrX:48689717..48689744 -
Hg19::chrX:54051809..54051811,+	p@chrX:54051809..54051811 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
1.28980561285789e-14	8.16446952939045e-12	9	272	Neuroactive ligand-receptor interaction (KEGG):04080
3.39083674685837e-07	0.000107319983038067	4	101	GnRH signaling pathway (KEGG):04912
0.000469054871716454	0.0494852889660859	2	54	Autoimmune thyroid disease (KEGG):05320
5.64655121093405e-07	0.000119142230550708	7	932	Signaling by GPCR (Reactome):REACT_14797
4.68717995579227e-06	0.000593396982403302	4	195	Metabolism of amino acids and derivatives (Reactome):REACT_13
2.72912932716038e-06	0.00043188471602313	6	733	{ARRB2,743} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005179	hormone activity	4.70217539406628e-06
GO:0005625	soluble fraction	4.70217539406628e-06
GO:0007165	signal transduction	0.000669354161378072
GO:0007154	cell communication	0.00102865316074998
GO:0008584	male gonad development	0.00116701178172978
GO:0000267	cell fraction	0.00116701178172978
GO:0046546	development of primary male sexual characteristics	0.00170211124438285
GO:0005102	receptor binding	0.00170211124438285
GO:0032501	multicellular organismal process	0.00195375485702507
GO:0046661	male sex differentiation	0.00199734198145008
GO:0008406	gonad development	0.00406384487868871
GO:0048608	reproductive structure development	0.00406384487868871
GO:0007275	multicellular organismal development	0.00406384487868871
GO:0032502	developmental process	0.00406384487868871
GO:0022414	reproductive process	0.00406384487868871
GO:0045137	development of primary sexual characteristics	0.00406384487868871
GO:0048609	reproductive process in a multicellular organism	0.00406384487868871
GO:0032504	multicellular organism reproduction	0.00406384487868871
GO:0007166	cell surface receptor linked signal transduction	0.00410264335334982
GO:0030070	insulin processing	0.00410264335334982
GO:0004978	adrenocorticotropin receptor activity	0.00410264335334982
GO:0016913	follicle-stimulating hormone activity	0.00410264335334982
GO:0004183	carboxypeptidase E activity	0.00410264335334982
GO:0048187	inhibin beta-B binding	0.00410264335334982
GO:0007186	G-protein coupled receptor protein signaling pathway	0.00477227000525781
GO:0007565	female pregnancy	0.00477227000525781
GO:0007548	sex differentiation	0.00477227000525781
GO:0003006	reproductive developmental process	0.00530528956091789
GO:0048186	inhibin beta-A binding	0.00656287675267367
GO:0005148	prolactin receptor binding	0.00656287675267367
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.00820190560634466
GO:0048513	organ development	0.00820190560634466
GO:0048856	anatomical structure development	0.00820190560634466
GO:0019935	cyclic-nucleotide-mediated signaling	0.00820190560634466
GO:0004968	gonadotropin-releasing hormone receptor activity	0.00820190560634466
GO:0060011	Sertoli cell proliferation	0.00820190560634466
GO:0050954	sensory perception of mechanical stimulus	0.00893161013195159
GO:0007605	sensory perception of sound	0.00893161013195159
GO:0048184	follistatin binding	0.0100925731730377
GO:0007267	cell-cell signaling	0.0142560561162987
GO:0048185	activin binding	0.0143944457968459
GO:0016486	peptide hormone processing	0.0160091274579621
GO:0007516	hemocyte development	0.0160091274579621
GO:0042386	hemocyte differentiation	0.017479382187223
GO:0051592	response to calcium ion	0.017479382187223
GO:0004977	melanocortin receptor activity	0.019232857529668
GO:0048731	system development	0.02114152694078
GO:0004999	vasoactive intestinal polypeptide receptor activity	0.026601334373413
GO:0019932	second-messenger-mediated signaling	0.0276871209729411
GO:0001541	ovarian follicle development	0.0353229218256498
GO:0007530	sex determination	0.0389003673633559
GO:0007595	lactation	0.0389003673633559
GO:0051704	multi-organism process	0.0389003673633559
GO:0016500	protein-hormone receptor activity	0.0392153810759798
GO:0043627	response to estrogen stimulus	0.0392153810759798
GO:0007190	adenylate cyclase activation	0.0402575045364685
GO:0022601	menstrual cycle phase	0.0404270122573776
GO:0022602	menstrual cycle process	0.0404270122573776
GO:0046983	protein dimerization activity	0.0404270122573776
GO:0045762	positive regulation of adenylate cyclase activity	0.0404270122573776
GO:0031281	positive regulation of cyclase activity	0.0404270122573776
GO:0051349	positive regulation of lyase activity	0.0404270122573776
GO:0042562	hormone binding	0.0404270122573776
GO:0008585	female gonad development	0.0413174251168308
GO:0046545	development of primary female sexual characteristics	0.0430154782450233
GO:0046660	female sex differentiation	0.0430154782450233
GO:0042698	menstrual cycle	0.0481783978042076
GO:0007292	female gamete generation	0.0495967772577401
GO:0010038	response to metal ion	0.0495967772577401

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
pituitary gland	3.29e-195	2
gland of diencephalon	1.55e-98	4
neuroendocrine gland	1.55e-98	4
diencephalon	4.76e-57	7
future diencephalon	4.76e-57	7
endocrine gland	1.42e-12	35
regional part of forebrain	1.07e-10	41
forebrain	1.07e-10	41
anterior neural tube	1.07e-10	41
future forebrain	1.07e-10	41
endocrine system	4.55e-10	45
regional part of nervous system	1.34e-08	53
regional part of brain	1.34e-08	53
neural tube	3.28e-08	56
neural rod	3.28e-08	56
future spinal cord	3.28e-08	56
neural keel	3.28e-08	56
gland	5.66e-08	59
pre-chordal neural plate	1.20e-07	61
brain	6.59e-07	68
future brain	6.59e-07	68

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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