Coexpression cluster:C579: Difference between revisions
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{{Coexpression_clusters | 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filament bundle formation!0.00284618870874619!7429;10083$GO:0007015!actin filament organization!0.00680066143724809!7429;10083$GO:0004058!aromatic-L-amino-acid decarboxylase activity!0.0157482632756387!1644$GO:0030046!parallel actin filament bundle formation!0.0157482632756387!10083$GO:0001917!photoreceptor inner segment!0.0251938834677571!10083$GO:0051014!actin filament severing!0.0364213865634692!7429$GO:0007168!receptor guanylyl cyclase signaling pathway!0.0364213865634692!2984$GO:0032420!stereocilium!0.0364213865634692!10083$GO:0032421!stereocilium bundle!0.0364213865634692!10083$GO:0001750!photoreceptor outer segment!0.0364213865634692!10083$GO:0030036!actin cytoskeleton organization and biogenesis!0.0364213865634692!7429;10083$GO:0050957!equilibrioception!0.0364213865634692!10083$GO:0030029!actin filament-based process!0.0364213865634692!7429;10083$GO:0031513!nonmotile primary cilium!0.0364213865634692!10083$GO:0004383!guanylate cyclase activity!0.0364213865634692!2984$GO:0016829!lyase activity!0.0364213865634692!2984;1644$GO:0042423!catecholamine biosynthetic process!0.0364213865634692!1644$GO:0046068!cGMP metabolic process!0.0364213865634692!2984$GO:0006182!cGMP biosynthetic process!0.0364213865634692!2984$GO:0042491!auditory receptor cell differentiation!0.0369540344387369!10083$GO:0042995!cell projection!0.0369540344387369!2984;10083$GO:0042490!mechanoreceptor differentiation!0.0392977188640581!10083$GO:0060113!inner ear receptor cell differentiation!0.0392977188640581!10083$GO:0045494!photoreceptor cell maintenance!0.0392977188640581!10083$GO:0000086!G2/M transition of mitotic cell cycle!0.0401284692083886!10083$GO:0050885!neuromuscular process controlling balance!0.0401284692083886!10083$GO:0005902!microvillus!0.0401284692083886!10083$GO:0008290!F-actin capping protein complex!0.0401284692083886!7429$GO:0051693!actin filament capping!0.0401284692083886!7429$GO:0051016!barbed-end actin filament capping!0.0401284692083886!7429$GO:0030835!negative regulation of actin filament depolymerization!0.0401284692083886!7429$GO:0050905!neuromuscular process!0.0401284692083886!10083$GO:0005903!brush border!0.0401284692083886!2984$GO:0030834!regulation of actin filament depolymerization!0.0401284692083886!7429$GO:0030042!actin filament depolymerization!0.0401284692083886!7429$GO:0046847!filopodium formation!0.0401284692083886!80115$GO:0030035!microspike biogenesis!0.0407360836108583!80115$GO:0006584!catecholamine metabolic process!0.0423741530874236!1644$GO:0018958!phenol metabolic process!0.0423741530874236!1644$GO:0042472!inner ear morphogenesis!0.0423741530874236!10083$GO:0042471!ear morphogenesis!0.0474400479121247!10083$GO:0009975!cyclase activity!0.0481390800315232!2984$GO:0016849!phosphorus-oxygen lyase activity!0.0481390800315232!2984$GO:0042401!biogenic amine biosynthetic 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;0.0966405,MA0102.2;1.1957,MA0258.1;0.964206,MA0259.1;0.104286,MA0442.1;0}} | ||
| | |||
}} | |||
Latest revision as of 11:26, 17 September 2013
Full id: C579_small_argyrophil_colon_duodenum_signet_temporal_Intestinal
Phase1 CAGE Peaks
| Hg19::chr10:129691195..129691212,- | p1@CLRN3 |
| Hg19::chr11:17565907..17565933,- | p1@USH1C |
| Hg19::chr11:17565934..17565939,- | p8@USH1C |
| Hg19::chr11:17565951..17565982,- | p2@USH1C |
| Hg19::chr12:14849553..14849558,- | p5@GUCY2C |
| Hg19::chr12:14849578..14849586,- | p3@GUCY2C |
| Hg19::chr14:39703084..39703110,+ | p10@CTAGE5 |
| Hg19::chr16:21244993..21245042,+ | p1@ANKS4B |
| Hg19::chr17:55163280..55163297,+ | p14@AKAP1 |
| Hg19::chr22:38506619..38506678,- | p2@BAIAP2L2 |
| Hg19::chr2:219283836..219283853,+ | p1@VIL1 |
| Hg19::chr2:219290413..219290430,+ | p@chr2:219290413..219290430 + |
| Hg19::chr4:40477740..40477760,- | p19@RBM47 |
| Hg19::chr4:40477770..40477783,- | p23@RBM47 |
| Hg19::chr7:50633078..50633140,- | p1@DDC |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0051017 | actin filament bundle formation | 0.00284618870874619 |
| GO:0007015 | actin filament organization | 0.00680066143724809 |
| GO:0004058 | aromatic-L-amino-acid decarboxylase activity | 0.0157482632756387 |
| GO:0030046 | parallel actin filament bundle formation | 0.0157482632756387 |
| GO:0001917 | photoreceptor inner segment | 0.0251938834677571 |
| GO:0051014 | actin filament severing | 0.0364213865634692 |
| GO:0007168 | receptor guanylyl cyclase signaling pathway | 0.0364213865634692 |
| GO:0032420 | stereocilium | 0.0364213865634692 |
| GO:0032421 | stereocilium bundle | 0.0364213865634692 |
| GO:0001750 | photoreceptor outer segment | 0.0364213865634692 |
| GO:0030036 | actin cytoskeleton organization and biogenesis | 0.0364213865634692 |
| GO:0050957 | equilibrioception | 0.0364213865634692 |
| GO:0030029 | actin filament-based process | 0.0364213865634692 |
| GO:0031513 | nonmotile primary cilium | 0.0364213865634692 |
| GO:0004383 | guanylate cyclase activity | 0.0364213865634692 |
| GO:0016829 | lyase activity | 0.0364213865634692 |
| GO:0042423 | catecholamine biosynthetic process | 0.0364213865634692 |
| GO:0046068 | cGMP metabolic process | 0.0364213865634692 |
| GO:0006182 | cGMP biosynthetic process | 0.0364213865634692 |
| GO:0042491 | auditory receptor cell differentiation | 0.0369540344387369 |
| GO:0042995 | cell projection | 0.0369540344387369 |
| GO:0042490 | mechanoreceptor differentiation | 0.0392977188640581 |
| GO:0060113 | inner ear receptor cell differentiation | 0.0392977188640581 |
| GO:0045494 | photoreceptor cell maintenance | 0.0392977188640581 |
| GO:0000086 | G2/M transition of mitotic cell cycle | 0.0401284692083886 |
| GO:0050885 | neuromuscular process controlling balance | 0.0401284692083886 |
| GO:0005902 | microvillus | 0.0401284692083886 |
| GO:0008290 | F-actin capping protein complex | 0.0401284692083886 |
| GO:0051693 | actin filament capping | 0.0401284692083886 |
| GO:0051016 | barbed-end actin filament capping | 0.0401284692083886 |
| GO:0030835 | negative regulation of actin filament depolymerization | 0.0401284692083886 |
| GO:0050905 | neuromuscular process | 0.0401284692083886 |
| GO:0005903 | brush border | 0.0401284692083886 |
| GO:0030834 | regulation of actin filament depolymerization | 0.0401284692083886 |
| GO:0030042 | actin filament depolymerization | 0.0401284692083886 |
| GO:0046847 | filopodium formation | 0.0401284692083886 |
| GO:0030035 | microspike biogenesis | 0.0407360836108583 |
| GO:0006584 | catecholamine metabolic process | 0.0423741530874236 |
| GO:0018958 | phenol metabolic process | 0.0423741530874236 |
| GO:0042472 | inner ear morphogenesis | 0.0423741530874236 |
| GO:0042471 | ear morphogenesis | 0.0474400479121247 |
| GO:0009975 | cyclase activity | 0.0481390800315232 |
| GO:0016849 | phosphorus-oxygen lyase activity | 0.0481390800315232 |
| GO:0042401 | biogenic amine biosynthetic process | 0.0484642007416722 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| metabolising cell | 1.81e-10 | 12 |
| endopolyploid cell | 1.81e-10 | 12 |
| parenchymal cell | 1.81e-10 | 12 |
| polyploid cell | 1.81e-10 | 12 |
| hepatocyte | 1.81e-10 | 12 |
| endodermal cell | 1.94e-08 | 58 |
| epithelial cell of stomach | 1.86e-07 | 3 |
| Ontology term | p-value | n |
|---|---|---|
| gastrointestinal system | 7.79e-36 | 25 |
| intestine | 4.97e-33 | 17 |
| large intestine | 4.64e-22 | 11 |
| subdivision of digestive tract | 3.57e-19 | 118 |
| lower digestive tract | 2.18e-16 | 5 |
| digestive system | 3.74e-16 | 145 |
| digestive tract | 3.74e-16 | 145 |
| primitive gut | 3.74e-16 | 145 |
| colon | 3.11e-14 | 9 |
| endoderm-derived structure | 3.92e-14 | 160 |
| endoderm | 3.92e-14 | 160 |
| presumptive endoderm | 3.92e-14 | 160 |
| digestive tract diverticulum | 1.09e-12 | 23 |
| rectum | 4.49e-12 | 4 |
| epithelium of foregut-midgut junction | 1.22e-11 | 25 |
| anatomical boundary | 1.22e-11 | 25 |
| hepatobiliary system | 1.22e-11 | 25 |
| foregut-midgut junction | 1.22e-11 | 25 |
| septum transversum | 1.22e-11 | 25 |
| sac | 4.39e-11 | 26 |
| small intestine | 2.45e-10 | 4 |
| hepatic diverticulum | 2.78e-10 | 22 |
| liver primordium | 2.78e-10 | 22 |
| gut epithelium | 3.17e-09 | 54 |
| abdomen element | 3.70e-09 | 54 |
| abdominal segment element | 3.70e-09 | 54 |
| liver | 4.82e-09 | 19 |
| digestive gland | 4.82e-09 | 19 |
| liver bud | 4.82e-09 | 19 |
| epithelial sac | 6.12e-09 | 25 |
| organ system subdivision | 1.84e-08 | 223 |
| abdominal segment of trunk | 4.89e-08 | 60 |
| abdomen | 4.89e-08 | 60 |
| multi-tissue structure | 6.61e-07 | 342 |
| trunk region element | 9.69e-07 | 101 |
| Ontology term | p-value | n |
|---|---|---|
| signet ring cell adenocarcinoma | 6.13e-11 | 2 |
| gastrointestinal system cancer | 1.03e-08 | 14 |
| adenocarcinoma | 9.83e-07 | 25 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.0132214 |
| MA0004.1 | 0.256222 |
| MA0006.1 | 0.137644 |
| MA0007.1 | 0.67744 |
| MA0009.1 | 0.669377 |
| MA0014.1 | 0.533948 |
| MA0017.1 | 2.911 |
| MA0019.1 | 0.38027 |
| MA0024.1 | 0.570967 |
| MA0025.1 | 0.796882 |
| MA0027.1 | 2.25966 |
| MA0028.1 | 0.148561 |
| MA0029.1 | 0.588958 |
| MA0030.1 | 0.578277 |
| MA0031.1 | 0.518602 |
| MA0038.1 | 0.34128 |
| MA0040.1 | 0.594421 |
| MA0041.1 | 0.27117 |
| MA0042.1 | 0.245557 |
| MA0043.1 | 0.669676 |
| MA0046.1 | 2.67755 |
| MA0048.1 | 0.441458 |
| MA0050.1 | 0.246257 |
| MA0051.1 | 0.337676 |
| MA0052.1 | 0.598036 |
| MA0055.1 | 0.0154739 |
| MA0056.1 | 0 |
| MA0057.1 | 0.420982 |
| MA0058.1 | 0.182945 |
| MA0059.1 | 0.182001 |
| MA0060.1 | 0.51173 |
| MA0061.1 | 0.198509 |
| MA0063.1 | 0 |
| MA0066.1 | 0.341645 |
| MA0067.1 | 0.975379 |
| MA0068.1 | 0.616525 |
| MA0069.1 | 0.655419 |
| MA0070.1 | 0.644843 |
| MA0071.1 | 0.831024 |
| MA0072.1 | 0.640598 |
| MA0073.1 | 8.00756e-06 |
| MA0074.1 | 0.337035 |
| MA0076.1 | 0.194691 |
| MA0077.1 | 0.633326 |
| MA0078.1 | 0.424186 |
| MA0081.1 | 0.18212 |
| MA0083.1 | 1.62113 |
| MA0084.1 | 1.15904 |
| MA0087.1 | 0.63829 |
| MA0088.1 | 0.426561 |
| MA0089.1 | 0 |
| MA0090.1 | 0.205547 |
| MA0091.1 | 0.258318 |
| MA0092.1 | 0.647316 |
| MA0093.1 | 0.139688 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.353174 |
| MA0101.1 | 0.141917 |
| MA0103.1 | 0.411001 |
| MA0105.1 | 0.376193 |
| MA0106.1 | 0.37688 |
| MA0107.1 | 0.0950422 |
| MA0108.2 | 0.515791 |
| MA0109.1 | 0 |
| MA0111.1 | 0.215855 |
| MA0113.1 | 0.39123 |
| MA0114.1 | 2.15005 |
| MA0115.1 | 4.91533 |
| MA0116.1 | 1.09759 |
| MA0117.1 | 0.705104 |
| MA0119.1 | 0.170362 |
| MA0122.1 | 0.729811 |
| MA0124.1 | 0.860724 |
| MA0125.1 | 0.779672 |
| MA0130.1 | 0 |
| MA0131.1 | 0.440395 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.698212 |
| MA0136.1 | 0.347318 |
| MA0139.1 | 0.0481205 |
| MA0140.1 | 0.30631 |
| MA0141.1 | 0.180729 |
| MA0142.1 | 0.489543 |
| MA0143.1 | 0.391385 |
| MA0144.1 | 0.0838502 |
| MA0145.1 | 1.04117 |
| MA0146.1 | 0.454099 |
| MA0147.1 | 0.326612 |
| MA0148.1 | 0.276339 |
| MA0149.1 | 0.298252 |
| MA0062.2 | 0.0512998 |
| MA0035.2 | 0.824687 |
| MA0039.2 | 1.29697 |
| MA0138.2 | 0.425279 |
| MA0002.2 | 0.0612545 |
| MA0137.2 | 0.153033 |
| MA0104.2 | 0.236755 |
| MA0047.2 | 0.366327 |
| MA0112.2 | 0.448515 |
| MA0065.2 | 0.751536 |
| MA0150.1 | 1.10274 |
| MA0151.1 | 0 |
| MA0152.1 | 0.311809 |
| MA0153.1 | 3.00863 |
| MA0154.1 | 0.187751 |
| MA0155.1 | 0.0403226 |
| MA0156.1 | 0.154615 |
| MA0157.1 | 0.46471 |
| MA0158.1 | 0 |
| MA0159.1 | 0.327637 |
| MA0160.1 | 1.43316 |
| MA0161.1 | 0 |
| MA0162.1 | 0.13181 |
| MA0163.1 | 0.0128736 |
| MA0164.1 | 1.03839 |
| MA0080.2 | 0.432036 |
| MA0018.2 | 0.378086 |
| MA0099.2 | 0.312108 |
| MA0079.2 | 0.0966405 |
| MA0102.2 | 1.1957 |
| MA0258.1 | 0.964206 |
| MA0259.1 | 0.104286 |
| MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| HDAC2#3066 | 5 | 4.47187341220875 | 0.00365865752308656 | 0.0184762116461311 |
| HNF4A#3172 | 6 | 9.25291614518148 | 2.32447243124585e-05 | 0.000507241070302727 |
| HNF4G#3174 | 4 | 7.66757934038581 | 0.00146585519209508 | 0.00938987060888236 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
