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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 11:46, 17 September 2013


Full id: C1498_CD4_CD8_Natural_NK_Eosinophils_Peripheral_Basophils



Phase1 CAGE Peaks

Hg19::chr2:162757013..162757026,+p@chr2:162757013..162757026
+
Hg19::chr2:162762129..162762142,+p@chr2:162762129..162762142
+
Hg19::chr2:228713485..228713496,-p@chr2:228713485..228713496
-
Hg19::chr3:125555350..125555354,+p@chr3:125555350..125555354
+
Hg19::chr3:129295980..129295991,+p@chr3:129295980..129295991
+
Hg19::chr8:67380079..67380085,-p@chr8:67380079..67380085
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
mature alpha-beta T cell1.77e-7718
alpha-beta T cell1.77e-7718
immature T cell1.77e-7718
mature T cell1.77e-7718
immature alpha-beta T cell1.77e-7718
T cell1.09e-5425
pro-T cell1.09e-5425
CD8-positive, alpha-beta T cell3.02e-5411
lymphoid lineage restricted progenitor cell2.33e-3452
lymphocyte1.27e-3353
common lymphoid progenitor1.27e-3353
nucleate cell3.13e-3255
leukocyte2.90e-24136
nongranular leukocyte2.07e-21115
CD4-positive, alpha-beta T cell5.62e-216
hematopoietic stem cell1.84e-18168
angioblastic mesenchymal cell1.84e-18168
hematopoietic cell3.31e-17177
natural killer cell5.73e-163
pro-NK cell5.73e-163
single nucleate cell9.95e-163
mononuclear cell9.95e-163
hematopoietic lineage restricted progenitor cell4.72e-15120
hematopoietic oligopotent progenitor cell6.10e-15161
hematopoietic multipotent progenitor cell6.10e-15161
basophil7.13e-153
thymocyte5.81e-112
double negative thymocyte5.81e-112
double-positive, alpha-beta thymocyte5.81e-112
DN4 thymocyte5.81e-112
DN1 thymic pro-T cell5.81e-112
DN2 thymocyte5.81e-112
DN3 thymocyte5.81e-112
immature single positive thymocyte5.81e-112
early T lineage precursor5.81e-112
granulocyte1.14e-098
circulating cell4.27e-086
naive T cell4.92e-083
blood cell4.65e-0711
CD4-positive, alpha-beta thymocyte9.91e-071
naive thymus-derived CD4-positive, alpha-beta T cell9.91e-071
mature CD4 single-positive thymocyte9.91e-071
resting double-positive thymocyte9.91e-071
double-positive blast9.91e-071
CD69-positive double-positive thymocyte9.91e-071
CD69-positive, CD4-positive single-positive thymocyte9.91e-071
CD4-positive, CD8-intermediate double-positive thymocyte9.91e-071
CD24-positive, CD4 single-positive thymocyte9.91e-071
Uber Anatomy
Ontology termp-valuen
thymus1.78e-114
hemolymphoid system gland1.78e-114
thymic region1.78e-114
pharyngeal gland1.78e-114
thymus primordium1.78e-114
blood3.35e-1115
haemolymphatic fluid3.35e-1115
organism substance3.35e-1115
hemopoietic organ4.18e-117
immune organ4.18e-117
pharyngeal epithelium8.36e-086


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00461978
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.108006
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.213007
MA0056.10
MA0057.10.147053
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.13.74531
MA0072.15.34965
MA0073.10.00563817
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.0971959
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.845337
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.226048
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.107156
MA0146.10.0213085
MA0147.10.327615
MA0148.11.42897
MA0149.10.612449
MA0062.20.658749
MA0035.20.621793
MA0039.20.00570825
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.26661
MA0047.21.66123
MA0112.20.101413
MA0065.20.718489
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.413181
MA0155.10.318517
MA0156.11.07131
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.0383129
MA0163.10.0270301
MA0164.10.738243
MA0080.21.02158
MA0018.20.709805
MA0099.20.629739
MA0079.27.22997e-05
MA0102.21.58513
MA0258.10.289793
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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