Coexpression cluster:C155: Difference between revisions
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{{Coexpression_clusters | {{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.55141387977931,0.840056949569502,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0|full_id=C155_pituitary_placenta_nonsmall_cervical_smallcell_choriocarcinoma_epitheloid|gostat_on_coexpression_clusters=GO:0005179!hormone activity!4.70217539406628e-06!7252;1081;2488;3972;5617$GO:0005625!soluble fraction!4.70217539406628e-06!1081;2488;8788;3972;5617$GO:0007165!signal transduction!0.000669354161378072!7252;4158;3547;2798;2692;1081;2488;1363;3972;5617$GO:0007154!cell communication!0.00102865316074998!7252;4158;3547;2798;2692;1081;2488;1363;3972;5617$GO:0008584!male gonad development!0.00116701178172978!2488;3972$GO:0000267!cell fraction!0.00116701178172978!1081;2488;8788;3972;5617$GO:0046546!development of primary male sexual characteristics!0.00170211124438285!2488;3972$GO:0005102!receptor binding!0.00170211124438285!7252;1081;2488;3972;5617$GO:0032501!multicellular organismal process!0.00195375485702507!51168;2692;150677;2488;8788;3972;2798;5617$GO:0046661!male sex differentiation!0.00199734198145008!2488;3972$GO:0008406!gonad development!0.00406384487868871!2488;3972$GO:0048608!reproductive structure development!0.00406384487868871!2488;3972$GO:0007275!multicellular organismal 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ion!0.0495967772577401!7252|id=C155|kegg_enrichment=hsa04080;Neuroactive_ligand-receptor_interaction;1.70E-14!hsa04912;GnRH_signaling_pathway;8.24E-06|ontology_enrichment_celltype=|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0000007!3.29e-195!2;UBERON:0003296!1.55e-98!4;UBERON:0010133!1.55e-98!4;UBERON:0001894!4.76e-57!7;UBERON:0006222!4.76e-57!7;UBERON:0002368!1.42e-12!35;UBERON:0002780!1.07e-10!41;UBERON:0001890!1.07e-10!41;UBERON:0003080!1.07e-10!41;UBERON:0006240!1.07e-10!41;UBERON:0000949!4.55e-10!45;UBERON:0000073!1.34e-08!53;UBERON:0002616!1.34e-08!53;UBERON:0001049!3.28e-08!56;UBERON:0005068!3.28e-08!56;UBERON:0006241!3.28e-08!56;UBERON:0007135!3.28e-08!56;UBERON:0002530!5.66e-08!59;UBERON:0003056!1.20e-07!61;UBERON:0000955!6.59e-07!68;UBERON:0006238!6.59e-07!68|pathway_enrichment=1.28980561285789e-14;8.16446952939045e-12;9;272;Neuroactive ligand-receptor interaction (KEGG):04080!3.39083674685837e-07;0.000107319983038067;4;101;GnRH signaling pathway (KEGG):04912!0.000469054871716454;0.0494852889660859;2;54;Autoimmune thyroid disease (KEGG):05320!5.64655121093405e-07;0.000119142230550708;7;932;Signaling by GPCR (Reactome):REACT_14797!4.68717995579227e-06;0.000593396982403302;4;195;Metabolism of amino acids and derivatives (Reactome):REACT_13!2.72912932716038e-06;0.00043188471602313;6;733;{ARRB2,743} (Static 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Latest revision as of 10:44, 17 September 2013
Full id: C155_pituitary_placenta_nonsmall_cervical_smallcell_choriocarcinoma_epitheloid
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
1.28980561285789e-14 | 8.16446952939045e-12 | 9 | 272 | Neuroactive ligand-receptor interaction (KEGG):04080 |
3.39083674685837e-07 | 0.000107319983038067 | 4 | 101 | GnRH signaling pathway (KEGG):04912 |
0.000469054871716454 | 0.0494852889660859 | 2 | 54 | Autoimmune thyroid disease (KEGG):05320 |
5.64655121093405e-07 | 0.000119142230550708 | 7 | 932 | Signaling by GPCR (Reactome):REACT_14797 |
4.68717995579227e-06 | 0.000593396982403302 | 4 | 195 | Metabolism of amino acids and derivatives (Reactome):REACT_13 |
2.72912932716038e-06 | 0.00043188471602313 | 6 | 733 | {ARRB2,743} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0005179 | hormone activity | 4.70217539406628e-06 |
GO:0005625 | soluble fraction | 4.70217539406628e-06 |
GO:0007165 | signal transduction | 0.000669354161378072 |
GO:0007154 | cell communication | 0.00102865316074998 |
GO:0008584 | male gonad development | 0.00116701178172978 |
GO:0000267 | cell fraction | 0.00116701178172978 |
GO:0046546 | development of primary male sexual characteristics | 0.00170211124438285 |
GO:0005102 | receptor binding | 0.00170211124438285 |
GO:0032501 | multicellular organismal process | 0.00195375485702507 |
GO:0046661 | male sex differentiation | 0.00199734198145008 |
GO:0008406 | gonad development | 0.00406384487868871 |
GO:0048608 | reproductive structure development | 0.00406384487868871 |
GO:0007275 | multicellular organismal development | 0.00406384487868871 |
GO:0032502 | developmental process | 0.00406384487868871 |
GO:0022414 | reproductive process | 0.00406384487868871 |
GO:0045137 | development of primary sexual characteristics | 0.00406384487868871 |
GO:0048609 | reproductive process in a multicellular organism | 0.00406384487868871 |
GO:0032504 | multicellular organism reproduction | 0.00406384487868871 |
GO:0007166 | cell surface receptor linked signal transduction | 0.00410264335334982 |
GO:0030070 | insulin processing | 0.00410264335334982 |
GO:0004978 | adrenocorticotropin receptor activity | 0.00410264335334982 |
GO:0016913 | follicle-stimulating hormone activity | 0.00410264335334982 |
GO:0004183 | carboxypeptidase E activity | 0.00410264335334982 |
GO:0048187 | inhibin beta-B binding | 0.00410264335334982 |
GO:0007186 | G-protein coupled receptor protein signaling pathway | 0.00477227000525781 |
GO:0007565 | female pregnancy | 0.00477227000525781 |
GO:0007548 | sex differentiation | 0.00477227000525781 |
GO:0003006 | reproductive developmental process | 0.00530528956091789 |
GO:0048186 | inhibin beta-A binding | 0.00656287675267367 |
GO:0005148 | prolactin receptor binding | 0.00656287675267367 |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | 0.00820190560634466 |
GO:0048513 | organ development | 0.00820190560634466 |
GO:0048856 | anatomical structure development | 0.00820190560634466 |
GO:0019935 | cyclic-nucleotide-mediated signaling | 0.00820190560634466 |
GO:0004968 | gonadotropin-releasing hormone receptor activity | 0.00820190560634466 |
GO:0060011 | Sertoli cell proliferation | 0.00820190560634466 |
GO:0050954 | sensory perception of mechanical stimulus | 0.00893161013195159 |
GO:0007605 | sensory perception of sound | 0.00893161013195159 |
GO:0048184 | follistatin binding | 0.0100925731730377 |
GO:0007267 | cell-cell signaling | 0.0142560561162987 |
GO:0048185 | activin binding | 0.0143944457968459 |
GO:0016486 | peptide hormone processing | 0.0160091274579621 |
GO:0007516 | hemocyte development | 0.0160091274579621 |
GO:0042386 | hemocyte differentiation | 0.017479382187223 |
GO:0051592 | response to calcium ion | 0.017479382187223 |
GO:0004977 | melanocortin receptor activity | 0.019232857529668 |
GO:0048731 | system development | 0.02114152694078 |
GO:0004999 | vasoactive intestinal polypeptide receptor activity | 0.026601334373413 |
GO:0019932 | second-messenger-mediated signaling | 0.0276871209729411 |
GO:0001541 | ovarian follicle development | 0.0353229218256498 |
GO:0007530 | sex determination | 0.0389003673633559 |
GO:0007595 | lactation | 0.0389003673633559 |
GO:0051704 | multi-organism process | 0.0389003673633559 |
GO:0016500 | protein-hormone receptor activity | 0.0392153810759798 |
GO:0043627 | response to estrogen stimulus | 0.0392153810759798 |
GO:0007190 | adenylate cyclase activation | 0.0402575045364685 |
GO:0022601 | menstrual cycle phase | 0.0404270122573776 |
GO:0022602 | menstrual cycle process | 0.0404270122573776 |
GO:0046983 | protein dimerization activity | 0.0404270122573776 |
GO:0045762 | positive regulation of adenylate cyclase activity | 0.0404270122573776 |
GO:0031281 | positive regulation of cyclase activity | 0.0404270122573776 |
GO:0051349 | positive regulation of lyase activity | 0.0404270122573776 |
GO:0042562 | hormone binding | 0.0404270122573776 |
GO:0008585 | female gonad development | 0.0413174251168308 |
GO:0046545 | development of primary female sexual characteristics | 0.0430154782450233 |
GO:0046660 | female sex differentiation | 0.0430154782450233 |
GO:0042698 | menstrual cycle | 0.0481783978042076 |
GO:0007292 | female gamete generation | 0.0495967772577401 |
GO:0010038 | response to metal ion | 0.0495967772577401 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
pituitary gland | 3.29e-195 | 2 |
gland of diencephalon | 1.55e-98 | 4 |
neuroendocrine gland | 1.55e-98 | 4 |
diencephalon | 4.76e-57 | 7 |
future diencephalon | 4.76e-57 | 7 |
endocrine gland | 1.42e-12 | 35 |
regional part of forebrain | 1.07e-10 | 41 |
forebrain | 1.07e-10 | 41 |
anterior neural tube | 1.07e-10 | 41 |
future forebrain | 1.07e-10 | 41 |
endocrine system | 4.55e-10 | 45 |
regional part of nervous system | 1.34e-08 | 53 |
regional part of brain | 1.34e-08 | 53 |
neural tube | 3.28e-08 | 56 |
neural rod | 3.28e-08 | 56 |
future spinal cord | 3.28e-08 | 56 |
neural keel | 3.28e-08 | 56 |
gland | 5.66e-08 | 59 |
pre-chordal neural plate | 1.20e-07 | 61 |
brain | 6.59e-07 | 68 |
future brain | 6.59e-07 | 68 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 1.22249e-07 |
MA0004.1 | 0.258678 |
MA0006.1 | 0.127228 |
MA0007.1 | 0.122597 |
MA0009.1 | 0.974804 |
MA0014.1 | 1.05304e-08 |
MA0017.1 | 0.619526 |
MA0019.1 | 0.0421399 |
MA0024.1 | 0.0451994 |
MA0025.1 | 0.4335 |
MA0027.1 | 1.39806 |
MA0028.1 | 0.00237158 |
MA0029.1 | 0.740911 |
MA0030.1 | 0.402604 |
MA0031.1 | 0.127261 |
MA0038.1 | 0.181784 |
MA0040.1 | 0.431833 |
MA0041.1 | 0.466281 |
MA0042.1 | 0.230679 |
MA0043.1 | 0.0800788 |
MA0046.1 | 0.26244 |
MA0048.1 | 0.834657 |
MA0050.1 | 0.232473 |
MA0051.1 | 0.0796943 |
MA0052.1 | 0.438484 |
MA0055.1 | 6.1232 |
MA0056.1 | 0 |
MA0057.1 | 0.0813124 |
MA0058.1 | 0.171046 |
MA0059.1 | 0.560635 |
MA0060.1 | 0.011294 |
MA0061.1 | 0.0364308 |
MA0063.1 | 0 |
MA0066.1 | 0.182363 |
MA0067.1 | 0.249504 |
MA0068.1 | 0.176467 |
MA0069.1 | 0.258385 |
MA0070.1 | 0.0702856 |
MA0071.1 | 0.873712 |
MA0072.1 | 0.888954 |
MA0073.1 | 0.0449156 |
MA0074.1 | 0.0791662 |
MA0076.1 | 0.00198607 |
MA0077.1 | 0.867625 |
MA0078.1 | 0.168469 |
MA0081.1 | 0.0957584 |
MA0083.1 | 0.282188 |
MA0084.1 | 0.384661 |
MA0087.1 | 0.882168 |
MA0088.1 | 0.000977818 |
MA0089.1 | 0 |
MA0090.1 | 0.940439 |
MA0091.1 | 4.30232 |
MA0092.1 | 0.308568 |
MA0093.1 | 0.132707 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0314397 |
MA0101.1 | 0.326014 |
MA0103.1 | 0.883413 |
MA0105.1 | 0.00184735 |
MA0106.1 | 0.00779354 |
MA0107.1 | 0.118639 |
MA0108.2 | 1.69308 |
MA0109.1 | 0 |
MA0111.1 | 0.0855886 |
MA0113.1 | 0.130629 |
MA0114.1 | 0.168451 |
MA0115.1 | 1.73094 |
MA0116.1 | 0.0767083 |
MA0117.1 | 0.0951982 |
MA0119.1 | 0.139585 |
MA0122.1 | 0.10652 |
MA0124.1 | 0.176386 |
MA0125.1 | 0.131237 |
MA0130.1 | 0 |
MA0131.1 | 0.0157595 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 2.79263 |
MA0136.1 | 0.548378 |
MA0139.1 | 0.159018 |
MA0140.1 | 0.0561548 |
MA0141.1 | 0.165287 |
MA0142.1 | 0.257034 |
MA0143.1 | 0.269374 |
MA0144.1 | 0.647201 |
MA0145.1 | 0.00221987 |
MA0146.1 | 1.05505e-06 |
MA0147.1 | 0.0817954 |
MA0148.1 | 1.91706 |
MA0149.1 | 0.0154146 |
MA0062.2 | 3.31939e-05 |
MA0035.2 | 0.129625 |
MA0039.2 | 1.06444e-07 |
MA0138.2 | 0.169805 |
MA0002.2 | 0.195358 |
MA0137.2 | 0.265784 |
MA0104.2 | 0.0704467 |
MA0047.2 | 1.97851 |
MA0112.2 | 0.00496636 |
MA0065.2 | 0.0751904 |
MA0150.1 | 0.344369 |
MA0151.1 | 0 |
MA0152.1 | 0.0599421 |
MA0153.1 | 0.122947 |
MA0154.1 | 0.046133 |
MA0155.1 | 0.815797 |
MA0156.1 | 0.0258084 |
MA0157.1 | 0.0198457 |
MA0158.1 | 0 |
MA0159.1 | 0.294742 |
MA0160.1 | 0.765441 |
MA0161.1 | 0 |
MA0162.1 | 3.3284e-05 |
MA0163.1 | 0.000879552 |
MA0164.1 | 0.757991 |
MA0080.2 | 0.00627249 |
MA0018.2 | 0.663246 |
MA0099.2 | 0.00310208 |
MA0079.2 | 1.01254e-14 |
MA0102.2 | 0.413769 |
MA0258.1 | 0.00381001 |
MA0259.1 | 0.152412 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data