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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.152965642259574

Latest revision as of 11:34, 17 September 2013


Full id: C964_Nucleus_Anulus_meningioma_large_Olfactory_Chondrocyte_Mesothelial



Phase1 CAGE Peaks

Hg19::chrX:119694291..119694298,-p21@CUL4B
Hg19::chrX:119694334..119694362,-p5@CUL4B
Hg19::chrX:119694463..119694476,-p17@CUL4B
Hg19::chrX:119694505..119694522,-p8@CUL4B
Hg19::chrX:119694538..119694549,-p20@CUL4B
Hg19::chrX:119694573..119694611,-p2@CUL4B
Hg19::chrX:119694622..119694642,-p3@CUL4B
Hg19::chrX:119694719..119694730,-p14@CUL4B
Hg19::chrX:119694739..119694751,-p12@CUL4B


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
vasculature4.68e-1278
vascular system4.68e-1278
cardiovascular system1.16e-11109
unilaminar epithelium2.53e-11148
circulatory system5.71e-11112
skeletal muscle tissue7.50e-1162
striated muscle tissue7.50e-1162
myotome7.50e-1162
muscle tissue2.83e-1064
musculature2.83e-1064
musculature of body2.83e-1064
dense mesenchyme tissue2.88e-1073
paraxial mesoderm4.50e-1072
presumptive paraxial mesoderm4.50e-1072
somite4.51e-1071
presomitic mesoderm4.51e-1071
presumptive segmental plate4.51e-1071
dermomyotome4.51e-1071
trunk paraxial mesoderm4.51e-1071
splanchnic layer of lateral plate mesoderm5.70e-1083
epithelial tube open at both ends6.07e-1059
blood vessel6.07e-1059
blood vasculature6.07e-1059
vascular cord6.07e-1059
vessel7.27e-1068
mesenchyme1.17e-09160
entire embryonic mesenchyme1.17e-09160
trunk mesenchyme2.57e-09122
epithelial vesicle5.91e-0978
artery2.36e-0842
arterial blood vessel2.36e-0842
arterial system2.36e-0842
systemic artery1.09e-0733
systemic arterial system1.09e-0733
epithelial tube1.36e-07117
anatomical cluster4.83e-07373
multilaminar epithelium7.59e-0783


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0149552
MA0004.10.415381
MA0006.13.78707
MA0007.10.397529
MA0009.10.870971
MA0014.10.580022
MA0017.10.301634
MA0019.10.558663
MA0024.10.766783
MA0025.11.00397
MA0027.12.48103
MA0028.10.280275
MA0029.10.785955
MA0030.10.774581
MA0031.10.710608
MA0038.10.514558
MA0040.10.791764
MA0041.10.433167
MA0042.10.402577
MA0043.10.871285
MA0046.10.860127
MA0048.12.55829
MA0050.10.403421
MA0051.12.19548
MA0052.10.795605
MA0055.115.1127
MA0056.10
MA0057.112.6851
MA0058.10.325084
MA0059.10.323879
MA0060.10.162248
MA0061.10.139804
MA0063.10
MA0066.10.514973
MA0067.11.18766
MA0068.13.774
MA0069.10.856287
MA0070.10.845142
MA0071.10.47692
MA0072.10.840664
MA0073.10.447621
MA0074.10.509711
MA0076.10.901394
MA0077.10.832987
MA0078.10.607575
MA0081.10.324031
MA0083.10.878452
MA0084.11.37471
MA0087.10.838229
MA0088.10.0408613
MA0089.10
MA0090.11.66392
MA0091.10.417885
MA0092.10.381858
MA0093.10.26836
MA0095.10
MA0098.10
MA0100.10.528088
MA0101.10.271368
MA0103.10.257174
MA0105.10.0643619
MA0106.10.554855
MA0107.10.205358
MA0108.20.707575
MA0109.10
MA0111.10.366362
MA0113.10.57094
MA0114.10.200901
MA0115.11.11137
MA0116.10.599942
MA0117.10.908433
MA0119.10.308914
MA0122.10.934245
MA0124.11.06995
MA0125.10.986127
MA0130.10
MA0131.10.625452
MA0132.10
MA0133.10
MA0135.10.90122
MA0136.10.521435
MA0139.10.129876
MA0140.10.474342
MA0141.10.322254
MA0142.10.679161
MA0143.10.571113
MA0144.10.1885
MA0145.10.046841
MA0146.10.0045741
MA0147.10.211483
MA0148.10.439278
MA0149.10.464973
MA0062.20.421263
MA0035.20.473658
MA0039.20.679176
MA0138.20.608783
MA0002.21.45266
MA0137.20.28622
MA0104.20.161609
MA0047.20.542971
MA0112.20.0433683
MA0065.21.10761
MA0150.10.919271
MA0151.10
MA0152.10.480711
MA0153.10.969315
MA0154.11.77574
MA0155.10.645215
MA0156.10.288314
MA0157.10.652111
MA0158.10
MA0159.11.79216
MA0160.10.453945
MA0161.10
MA0162.10.14518
MA0163.10.384654
MA0164.10.583138
MA0080.20.268439
MA0018.20.556211
MA0099.20.481058
MA0079.212.3324
MA0102.21.41188
MA0258.10.180288
MA0259.10.218904
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105154.428415347680450.00252258685237060.0139883427989133
EGR1#195884.433936973164571.92853122912633e-050.000435489455218865
ELK4#2005712.62775240103071.08190108922051e-076.31243954508943e-06
ETS1#211344.323893743201040.009187536739323920.0347482128455947
FOXA1#316956.156344305214140.000551925905874990.00471282721639098
FOXA2#3170513.68359097370291.21001374207767e-050.000302979202131022
HEY1#2346283.591209816093969.88548321897326e-050.00139254111398213
IRF1#365954.242868751979950.003062032867748010.0161464026393383
MXI1#460144.427365168337470.008444657415134930.032780210956301
POLR2A#543092.147453176558070.001029412892608020.00729035417990706
SRF#672257.665099034537670.0001964447812163450.00236174703642844
TAF1#687282.971596698440260.0004233749951234810.00395995532112675
USF1#739153.534166265115530.00692296754081810.02931154201952
USF2#739268.661464923379731.42236000274901e-050.000340398387550651



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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