Coexpression cluster:C3324: Difference between revisions
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|pathway_enrichment=5.10526184734612e-06;0.00161581537468505;2;65;Glycolysis / Gluconeogenesis (KEGG):00010!2.76862277106078e-06;0.00161581537468505;2;48;Glycolysis and Gluconeogenesis (Wikipathways):WP534!1.93288158883898e-05;0.00407838015245025;2;126;Metabolism of carbohydrates (Reactome):REACT_474 | |pathway_enrichment=5.10526184734612e-06;0.00161581537468505;2;65;Glycolysis / Gluconeogenesis (KEGG):00010!2.76862277106078e-06;0.00161581537468505;2;48;Glycolysis and Gluconeogenesis (Wikipathways):WP534!1.93288158883898e-05;0.00407838015245025;2;126;Metabolism of carbohydrates (Reactome):REACT_474 | ||
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}} | }} |
Revision as of 16:04, 26 November 2012
Full id: C3324_Smooth_Tracheal_mucinous_Bronchial_chronic_iPS_testicular
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
5.10526184734612e-06 | 0.00161581537468505 | 2 | 65 | Glycolysis / Gluconeogenesis (KEGG):00010 |
2.76862277106078e-06 | 0.00161581537468505 | 2 | 48 | Glycolysis and Gluconeogenesis (Wikipathways):WP534 |
1.93288158883898e-05 | 0.00407838015245025 | 2 | 126 | Metabolism of carbohydrates (Reactome):REACT_474 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006096 | glycolysis | 0.000540199366548864 |
GO:0006007 | glucose catabolic process | 0.000540199366548864 |
GO:0019320 | hexose catabolic process | 0.000540199366548864 |
GO:0046365 | monosaccharide catabolic process | 0.000540199366548864 |
GO:0046164 | alcohol catabolic process | 0.000540199366548864 |
GO:0044275 | cellular carbohydrate catabolic process | 0.000540199366548864 |
GO:0016052 | carbohydrate catabolic process | 0.000540199366548864 |
GO:0006006 | glucose metabolic process | 0.000540199366548864 |
GO:0019682 | glyceraldehyde-3-phosphate metabolic process | 0.000801364291142872 |
GO:0019318 | hexose metabolic process | 0.000801364291142872 |
GO:0005996 | monosaccharide metabolic process | 0.000801364291142872 |
GO:0006066 | alcohol metabolic process | 0.00194031033381917 |
GO:0044262 | cellular carbohydrate metabolic process | 0.00222563009254727 |
GO:0044265 | cellular macromolecule catabolic process | 0.00229801901433619 |
GO:0008243 | plasminogen activator activity | 0.0026687074290719 |
GO:0009057 | macromolecule catabolic process | 0.00287246063691723 |
GO:0004807 | triose-phosphate isomerase activity | 0.00381215860215283 |
GO:0005975 | carbohydrate metabolic process | 0.00381215860215283 |
GO:0044248 | cellular catabolic process | 0.00381215860215283 |
GO:0000015 | phosphopyruvate hydratase complex | 0.00381215860215283 |
GO:0004634 | phosphopyruvate hydratase activity | 0.00381215860215283 |
GO:0006098 | pentose-phosphate shunt | 0.00452466669138058 |
GO:0006740 | NADPH regeneration | 0.00452466669138058 |
GO:0009056 | catabolic process | 0.00464384082415092 |
GO:0006739 | NADP metabolic process | 0.00544320154386884 |
GO:0006081 | aldehyde metabolic process | 0.00738819991474676 |
GO:0006094 | gluconeogenesis | 0.00741089388558953 |
GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses | 0.00771768936066741 |
GO:0006090 | pyruvate metabolic process | 0.00800329401828087 |
GO:0006769 | nicotinamide metabolic process | 0.0088031049041376 |
GO:0019319 | hexose biosynthetic process | 0.00894367264301036 |
GO:0046165 | alcohol biosynthetic process | 0.00894367264301036 |
GO:0019362 | pyridine nucleotide metabolic process | 0.00894367264301036 |
GO:0046364 | monosaccharide biosynthetic process | 0.00894367264301036 |
GO:0006733 | oxidoreduction coenzyme metabolic process | 0.0114297418328042 |
GO:0030308 | negative regulation of cell growth | 0.0116761834286374 |
GO:0045792 | negative regulation of cell size | 0.0116761834286374 |
GO:0045926 | negative regulation of growth | 0.0128413395414501 |
GO:0006767 | water-soluble vitamin metabolic process | 0.0131268421898135 |
GO:0016860 | intramolecular oxidoreductase activity | 0.0137975509083469 |
GO:0006633 | fatty acid biosynthetic process | 0.0142405352847658 |
GO:0046394 | carboxylic acid biosynthetic process | 0.0154359354486916 |
GO:0016053 | organic acid biosynthetic process | 0.0154359354486916 |
GO:0006766 | vitamin metabolic process | 0.0156296729918687 |
GO:0016836 | hydro-lyase activity | 0.0159922110028098 |
GO:0016835 | carbon-oxygen lyase activity | 0.0175538202251983 |
GO:0003714 | transcription corepressor activity | 0.0181993389241271 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 0.0211448259831228 |
GO:0016051 | carbohydrate biosynthetic process | 0.0225037134075076 |
GO:0001558 | regulation of cell growth | 0.0258798910505056 |
GO:0044445 | cytosolic part | 0.0293265925339893 |
GO:0006631 | fatty acid metabolic process | 0.0293265925339893 |
GO:0016049 | cell growth | 0.0293639592890473 |
GO:0040008 | regulation of growth | 0.0293639592890473 |
GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0293639592890473 |
GO:0008361 | regulation of cell size | 0.0293639592890473 |
GO:0016564 | transcription repressor activity | 0.0299656044669309 |
GO:0016829 | lyase activity | 0.0380323582947717 |
GO:0032787 | monocarboxylic acid metabolic process | 0.0380323582947717 |
GO:0006732 | coenzyme metabolic process | 0.0380323582947717 |
GO:0016481 | negative regulation of transcription | 0.0380323582947717 |
GO:0003712 | transcription cofactor activity | 0.0388270803655245 |
GO:0016853 | isomerase activity | 0.0397210780239578 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0397210780239578 |
GO:0008610 | lipid biosynthetic process | 0.0401829081725927 |
GO:0004252 | serine-type endopeptidase activity | 0.0401829081725927 |
GO:0009117 | nucleotide metabolic process | 0.0401829081725927 |
GO:0051186 | cofactor metabolic process | 0.0401829081725927 |
GO:0055086 | nucleobase, nucleoside and nucleotide metabolic process | 0.042131259085518 |
GO:0008236 | serine-type peptidase activity | 0.042131259085518 |
GO:0017171 | serine hydrolase activity | 0.042131259085518 |
GO:0031324 | negative regulation of cellular metabolic process | 0.042131259085518 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0461062077148254 |
GO:0008134 | transcription factor binding | 0.0462469925712618 |
GO:0009892 | negative regulation of metabolic process | 0.0462469925712618 |
GO:0000287 | magnesium ion binding | 0.0467822848085108 |
GO:0000902 | cell morphogenesis | 0.0487215706423031 |
GO:0032989 | cellular structure morphogenesis | 0.0487215706423031 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
animal cell | 3.01e-18 | 679 |
eukaryotic cell | 3.01e-18 | 679 |
embryonic cell | 7.86e-14 | 250 |
native cell | 1.27e-13 | 722 |
somatic cell | 3.27e-11 | 588 |
mesodermal cell | 3.86e-11 | 121 |
electrically responsive cell | 4.88e-09 | 61 |
electrically active cell | 4.88e-09 | 61 |
epithelial cell | 1.28e-08 | 253 |
muscle precursor cell | 1.47e-08 | 58 |
myoblast | 1.47e-08 | 58 |
multi-potent skeletal muscle stem cell | 1.47e-08 | 58 |
muscle cell | 4.68e-08 | 55 |
contractile cell | 5.45e-08 | 59 |
non-terminally differentiated cell | 5.63e-08 | 106 |
smooth muscle cell | 7.64e-08 | 43 |
smooth muscle myoblast | 7.64e-08 | 43 |
vascular associated smooth muscle cell | 2.51e-07 | 32 |
Ontology term | p-value | n |
---|---|---|
artery | 5.36e-11 | 42 |
arterial blood vessel | 5.36e-11 | 42 |
arterial system | 5.36e-11 | 42 |
epithelial vesicle | 1.39e-10 | 78 |
unilaminar epithelium | 1.85e-09 | 148 |
dense mesenchyme tissue | 3.31e-09 | 73 |
somite | 3.50e-09 | 71 |
presomitic mesoderm | 3.50e-09 | 71 |
presumptive segmental plate | 3.50e-09 | 71 |
dermomyotome | 3.50e-09 | 71 |
trunk paraxial mesoderm | 3.50e-09 | 71 |
paraxial mesoderm | 3.73e-09 | 72 |
presumptive paraxial mesoderm | 3.73e-09 | 72 |
epithelial tube open at both ends | 5.11e-09 | 59 |
blood vessel | 5.11e-09 | 59 |
blood vasculature | 5.11e-09 | 59 |
vascular cord | 5.11e-09 | 59 |
epithelial tube | 5.18e-09 | 117 |
multilaminar epithelium | 2.55e-08 | 83 |
vessel | 4.57e-08 | 68 |
vasculature | 9.04e-08 | 78 |
vascular system | 9.04e-08 | 78 |
splanchnic layer of lateral plate mesoderm | 9.23e-08 | 83 |
systemic artery | 1.27e-07 | 33 |
systemic arterial system | 1.27e-07 | 33 |
trunk mesenchyme | 2.87e-07 | 122 |
skeletal muscle tissue | 5.44e-07 | 62 |
striated muscle tissue | 5.44e-07 | 62 |
myotome | 5.44e-07 | 62 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.