MCL coexpression mm9:1331

Phase1 CAGE Peaks

	Short description
Mm9::chr12:79849983..79850006,+	p2@Mpp5
Mm9::chr19:6306626..6306638,+	p4@Cdc42bpg
Mm9::chr2:167906524..167906535,+	p4@Pard6b
Mm9::chr2:167906603..167906622,+	p1@Pard6b
Mm9::chr2:167906639..167906655,+	p2@Pard6b
Mm9::chr2:4638871..4638939,+	p1@Bend7

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005923	tight junction	0.00170156244089007
GO:0043296	apical junction complex	0.00170156244089007
GO:0016327	apicolateral plasma membrane	0.00170156244089007
GO:0005911	intercellular junction	0.00355302463365568
GO:0004385	guanylate kinase activity	0.00933391733597315
GO:0030054	cell junction	0.0153730212532083
GO:0019201	nucleotide kinase activity	0.0249864984349492
GO:0016776	phosphotransferase activity, phosphate group as acceptor	0.0407822118572064
GO:0019205	nucleobase, nucleoside, nucleotide kinase activity	0.0426733997204883
GO:0016301	kinase activity	0.0426733997204883
GO:0019992	diacylglycerol binding	0.0426733997204883
GO:0005938	cell cortex	0.0426733997204883
GO:0016772	transferase activity, transferring phosphorus-containing groups	0.0426733997204883
GO:0007242	intracellular signaling cascade	0.0426733997204883

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	2.06e-07	25

Uber Anatomy

Ontology term	p-value	n
intestine	2.41e-14	31
gastrointestinal system	3.96e-12	47
mucosa	3.51e-09	15
anatomical space	4.86e-09	57
endoderm-derived structure	5.68e-09	118
endoderm	5.68e-09	118
presumptive endoderm	5.68e-09	118
thoracic cavity element	6.69e-09	17
thoracic segment organ	6.69e-09	17
thoracic cavity	6.69e-09	17
thoracic segment of trunk	6.69e-09	17
respiratory primordium	6.69e-09	17
endoderm of foregut	6.69e-09	17
immaterial anatomical entity	9.10e-09	79
digestive system	1.29e-08	116
digestive tract	1.29e-08	116
primitive gut	1.29e-08	116
intestinal mucosa	2.69e-08	13
anatomical wall	2.69e-08	13
wall of intestine	2.69e-08	13
gastrointestinal system mucosa	2.69e-08	13
trunk region element	5.42e-08	79
subdivision of digestive tract	6.01e-08	114
epithelial bud	3.95e-07	17
lung	4.16e-07	14
respiratory tube	4.16e-07	14
respiration organ	4.16e-07	14
pair of lungs	4.16e-07	14
lung primordium	4.16e-07	14
lung bud	4.16e-07	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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