Coexpression cluster:C4080

Full id: C4080_CD19_CD4_Dendritic_Peripheral_CD14_B_Eosinophils

Phase1 CAGE Peaks

Hg19::chr21:45663884..45663922,-	p@chr21:45663884..45663922 -
Hg19::chr21:45663952..45663967,-	p@chr21:45663952..45663967 -
Hg19::chr2:227701085..227701125,-	p@chr2:227701085..227701125 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	6.31e-36	140
nongranular leukocyte	1.56e-32	119
hematopoietic stem cell	4.34e-30	172
angioblastic mesenchymal cell	4.34e-30	172
hematopoietic lineage restricted progenitor cell	3.09e-29	124
hematopoietic cell	5.28e-29	182
hematopoietic oligopotent progenitor cell	9.86e-27	165
hematopoietic multipotent progenitor cell	9.86e-27	165
lymphocyte	5.25e-23	53
common lymphoid progenitor	5.25e-23	53
lymphoid lineage restricted progenitor cell	1.77e-22	52
CD14-positive, CD16-negative classical monocyte	1.95e-19	42
classical monocyte	6.21e-17	45
lymphocyte of B lineage	1.13e-15	24
pro-B cell	1.13e-15	24
myeloid leukocyte	2.19e-11	76
B cell	1.69e-10	14
macrophage dendritic cell progenitor	1.73e-10	65
granulocyte monocyte progenitor cell	2.63e-10	71
monopoietic cell	8.79e-10	63
monocyte	8.79e-10	63
monoblast	8.79e-10	63
promonocyte	8.79e-10	63
myeloid lineage restricted progenitor cell	1.07e-08	70
myeloid cell	2.19e-08	112
common myeloid progenitor	2.19e-08	112
T cell	2.09e-07	25
pro-T cell	2.09e-07	25
mesenchymal cell	2.67e-07	358

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	1.51e-15	112
hematopoietic system	2.38e-14	102
blood island	2.38e-14	102
immune system	5.27e-10	115
bone marrow	5.35e-08	80
bone element	6.70e-08	86

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	3	24.3578017923036	6.91705216281876e-05	0.00109989343914834
BCL11A#53335	3	28.3694551036071	4.37778126761649e-05	0.000778231655844423
BCL3#602	2	23.0314018691589	0.00246467476084291	0.013855537051764
BCLAF1#9774	3	21.6526476101218	9.8473954032885e-05	0.00139337776524055
BHLHE40#8553	2	29.9145423646516	0.00146748352710614	0.00939857190699937
EBF1#1879	3	8.906466846569	0.0014152328356098	0.00916395945925056
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0463148979561831
FOSL2#2355	2	11.2868004030411	0.010053458697312	0.0376807167733201
FOXA2#3170	2	16.4203091684435	0.00481068235210548	0.0225950195256136
GATA3#2625	2	18.1576775714707	0.00394454681927962	0.0189539694160913
HNF4G#3174	2	19.1689483509645	0.00354398661128422	0.0179744763838341
IRF4#3662	3	21.9145126867441	9.49854535978121e-05	0.00136849024531686
MAX#4149	3	6.45255550900712	0.00372191383426551	0.0186872246015507
MEF2A#4205	2	12.495487273096	0.00823502947802974	0.0324893564391035
MEF2C#4208	2	27.5409029950827	0.00172911993836969	0.0106484791109967
MYC#4609	3	5.2222818716094	0.00702084375574015	0.0294999155538198
NFKB1#4790	3	5.48806342419384	0.00604938181565543	0.0269984781609862
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0173163684614205
PBX3#5090	2	14.6096751244961	0.00605612247321789	0.0268427354318382
POU2F2#5452	3	9.10612405774252	0.00132416519268213	0.0088327577798128
SMARCB1#6598	2	12.1684771874383	0.00867500222192174	0.032996159846139
SMARCC1#6599	2	29.1089062130876	0.00154920081422414	0.00984346193567893
SMC3#9126	2	10.0299552299552	0.012665637976747	0.0457600776508624
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0246952157435949
TRIM28#10155	2	12.3936833635083	0.00836834412943847	0.0329195635441796
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0190631755906616
WRNIP1#56897	2	73.2133095662507	0.00024709364113596	0.00268562938771969
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0329921845087611
ZBTB33#10009	2	21.1098166866541	0.00292859706060324	0.0156394001335758
ZEB1#6935	2	11.2589546783626	0.0101022267664633	0.0378187132146627

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.