Coexpression cluster:C359
From FANTOM5_SSTAR
Full id: C359_xeroderma_tonsil_acute_colon_lymph_trachea_bladder
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0008654 | phospholipid biosynthetic process | 0.010737464781943 |
GO:0046467 | membrane lipid biosynthetic process | 0.010737464781943 |
GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine | 0.010737464781943 |
GO:0018262 | isopeptide cross-linking | 0.010737464781943 |
GO:0018199 | peptidyl-glutamine modification | 0.010737464781943 |
GO:0004307 | ethanolaminephosphotransferase activity | 0.0111736804937354 |
GO:0004142 | diacylglycerol cholinephosphotransferase activity | 0.0111736804937354 |
GO:0006644 | phospholipid metabolic process | 0.0111736804937354 |
GO:0019863 | IgE binding | 0.0142568348656904 |
GO:0006643 | membrane lipid metabolic process | 0.0142568348656904 |
GO:0010224 | response to UV-B | 0.0146376878124516 |
GO:0008610 | lipid biosynthetic process | 0.0165118839613148 |
GO:0017169 | CDP-alcohol phosphatidyltransferase activity | 0.0165118839613148 |
GO:0018205 | peptidyl-lysine modification | 0.0172477522886803 |
GO:0006032 | chitin catabolic process | 0.0186546222107435 |
GO:0006046 | N-acetylglucosamine catabolic process | 0.0186546222107435 |
GO:0005789 | endoplasmic reticulum membrane | 0.0186546222107435 |
GO:0006043 | glucosamine catabolic process | 0.0186546222107435 |
GO:0046348 | amino sugar catabolic process | 0.0186546222107435 |
GO:0006030 | chitin metabolic process | 0.0186546222107435 |
GO:0004568 | chitinase activity | 0.0186546222107435 |
GO:0042175 | nuclear envelope-endoplasmic reticulum network | 0.0186546222107435 |
GO:0019865 | immunoglobulin binding | 0.0186546222107435 |
GO:0044432 | endoplasmic reticulum part | 0.0208492312452853 |
GO:0044247 | cellular polysaccharide catabolic process | 0.0208492312452853 |
GO:0000272 | polysaccharide catabolic process | 0.0208492312452853 |
GO:0016780 | phosphotransferase activity, for other substituted phosphate groups | 0.0208492312452853 |
GO:0001533 | cornified envelope | 0.0210604286585 |
GO:0018149 | peptide cross-linking | 0.0240242630131579 |
GO:0000030 | mannosyltransferase activity | 0.0241148894453259 |
GO:0006506 | GPI anchor biosynthetic process | 0.0250619670405395 |
GO:0030216 | keratinocyte differentiation | 0.0251141318157448 |
GO:0006505 | GPI anchor metabolic process | 0.0251630157626931 |
GO:0009411 | response to UV | 0.0253310637807865 |
GO:0006044 | N-acetylglucosamine metabolic process | 0.0253310637807865 |
GO:0046489 | phosphoinositide biosynthetic process | 0.0253310637807865 |
GO:0006041 | glucosamine metabolic process | 0.0253310637807865 |
GO:0031424 | keratinization | 0.0267667332897792 |
GO:0044255 | cellular lipid metabolic process | 0.0267667332897792 |
GO:0006040 | amino sugar metabolic process | 0.0267667332897792 |
GO:0005178 | integrin binding | 0.0267667332897792 |
GO:0046474 | glycerophospholipid biosynthetic process | 0.0293051626849468 |
GO:0009913 | epidermal cell differentiation | 0.0304836773360426 |
GO:0006497 | protein amino acid lipidation | 0.0319707530670764 |
GO:0042158 | lipoprotein biosynthetic process | 0.0319707530670764 |
GO:0048730 | epidermis morphogenesis | 0.0319707530670764 |
GO:0005783 | endoplasmic reticulum | 0.0320917655350622 |
GO:0006629 | lipid metabolic process | 0.0341520913372628 |
GO:0048729 | tissue morphogenesis | 0.0384680295948203 |
GO:0012505 | endomembrane system | 0.0384680295948203 |
GO:0030384 | phosphoinositide metabolic process | 0.0415056245270081 |
GO:0009416 | response to light stimulus | 0.0415056245270081 |
GO:0042157 | lipoprotein metabolic process | 0.0415056245270081 |
GO:0044264 | cellular polysaccharide metabolic process | 0.0415056245270081 |
GO:0005976 | polysaccharide metabolic process | 0.0417151002173427 |
GO:0030674 | protein binding, bridging | 0.0433362327013298 |
GO:0006650 | glycerophospholipid metabolic process | 0.0456192018890636 |
GO:0009314 | response to radiation | 0.0456192018890636 |
GO:0032403 | protein complex binding | 0.0456192018890636 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
adult organism | 7.41e-27 | 115 |
hematopoietic system | 1.93e-14 | 102 |
blood island | 1.93e-14 | 102 |
hemolymphoid system | 6.85e-13 | 112 |
blood | 3.38e-08 | 15 |
haemolymphatic fluid | 3.38e-08 | 15 |
organism substance | 3.38e-08 | 15 |
Ontology term | p-value | n |
---|---|---|
hematologic cancer | 3.18e-07 | 51 |
immune system cancer | 3.18e-07 | 51 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.