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Coexpression cluster:C554

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Full id: C554_Mast_Natural_CD8_CD14_CD4_Basophils_CD34



Phase1 CAGE Peaks

Hg19::chr10:3852591..3852602,-p@chr10:3852591..3852602
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Hg19::chr10:3934581..3934590,-p@chr10:3934581..3934590
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Hg19::chr17:7746197..7746211,+p@chr17:7746197..7746211
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Hg19::chr18:2972215..2972224,-p@chr18:2972215..2972224
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Hg19::chr19:40502828..40502848,-p@chr19:40502828..40502848
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Hg19::chr1:156076015..156076041,-p@chr1:156076015..156076041
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Hg19::chr1:156083971..156084011,-p@chr1:156083971..156084011
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Hg19::chr1:156084289..156084307,-p@chr1:156084289..156084307
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Hg19::chr1:59250073..59250095,+p@chr1:59250073..59250095
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Hg19::chr20:24930639..24930652,+p@chr20:24930639..24930652
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Hg19::chr22:39548943..39548962,+p@chr22:39548943..39548962
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Hg19::chr2:225906150..225906177,-p@chr2:225906150..225906177
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Hg19::chr5:130600546..130600567,-p@chr5:130600546..130600567
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Hg19::chr7:157069496..157069512,-p@chr7:157069496..157069512
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Hg19::chr8:38644503..38644535,-p@chr8:38644503..38644535
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Hg19::chr9:136017930..136017940,+p@chr9:136017930..136017940
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.03e-38140
hematopoietic stem cell1.87e-30172
angioblastic mesenchymal cell1.87e-30172
hematopoietic lineage restricted progenitor cell2.45e-29124
nongranular leukocyte3.15e-29119
hematopoietic cell3.61e-28182
hematopoietic oligopotent progenitor cell4.58e-27165
hematopoietic multipotent progenitor cell4.58e-27165
classical monocyte3.50e-2445
CD14-positive, CD16-negative classical monocyte5.82e-2442
myeloid leukocyte2.38e-1876
mesenchymal cell3.20e-18358
connective tissue cell3.33e-18365
granulocyte monocyte progenitor cell5.12e-1771
motile cell6.66e-16390
macrophage dendritic cell progenitor7.07e-1565
myeloid lineage restricted progenitor cell1.42e-1470
monopoietic cell7.77e-1463
monocyte7.77e-1463
monoblast7.77e-1463
promonocyte7.77e-1463
lymphocyte8.08e-1453
common lymphoid progenitor8.08e-1453
lymphoid lineage restricted progenitor cell1.29e-1352
myeloid cell1.61e-13112
common myeloid progenitor1.61e-13112
multi fate stem cell7.79e-13430
stem cell9.02e-12444
somatic stem cell2.26e-11436
lymphocyte of B lineage7.96e-0724
pro-B cell7.96e-0724
Uber Anatomy
Ontology termp-valuen
bone element7.17e-1986
bone marrow8.62e-1980
hematopoietic system2.51e-18102
blood island2.51e-18102
connective tissue5.47e-18375
hemolymphoid system3.98e-16112
skeletal element9.39e-15101
skeletal system9.39e-15101
immune system6.77e-14115


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#5333558.86545471987720.0001712746542035670.00208895873062786
EGR1#195882.494089547405070.0071065613147760.029627645888543
FOS#235373.93660544764130.0009600132569505240.00690658018479409
FOSL1#806137.446296196819940.006988269650209680.0295389304677938
FOSL2#235555.290687688925530.001809065771084470.0109414535595489
JUN#372564.692310947126130.001030862620745210.00729221493145552
MAX#414972.822993035190620.00671495219734910.0285430562693912
MEF2A#420544.685807727411010.008783099930456450.0333623631073628
MXI1#460163.735589360784740.00336025903705470.0173304737565904
NFKB1#479082.744031712096920.003856163139355890.0190237988715725
PAX5#507983.334782765588910.001055267737319320.00745677315411991
POU2F2#545273.983929275262350.0008930219510760040.00664763503552579
SMARCA4#6597219.5957379134860.004597623869893720.0217262223133718
SMARCC1#659938.18687987243090.005376255197450410.0246971944828029
SRF#672254.311618206927440.004430314153512830.0209735542304849
STAT1#677256.470808592874750.0007317668712721070.00582729700867614
STAT3#677463.944799373932840.002544236462237630.0140867047595629
TAF1#6872122.507284714308970.0002576836954007160.00276419756203321
TBP#6908112.548404847378770.0005856282752669240.00490633975939373
TCF12#693863.987924338319910.002406057678715160.0135661749126671
TCF7L2#693453.365680175980420.01257049842947540.0454603790115996



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.