MCL coexpression mm9:84
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005179 | hormone activity | 1.55673854052896e-06 |
| GO:0005102 | receptor binding | 0.000667694344920263 |
| GO:0030141 | secretory granule | 0.00139708723143257 |
| GO:0040018 | positive regulation of multicellular organism growth | 0.0265181819214404 |
| GO:0045927 | positive regulation of growth | 0.0297602743015208 |
| GO:0005126 | hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 0.0340312509722374 |
| GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process | 0.0340312509722374 |
| GO:0032958 | inositol phosphate biosynthetic process | 0.0340312509722374 |
| GO:0032960 | regulation of inositol trisphosphate biosynthetic process | 0.0340312509722374 |
| GO:0032959 | inositol trisphosphate biosynthetic process | 0.0340312509722374 |
| GO:0004968 | gonadotropin-releasing hormone receptor activity | 0.0340312509722374 |
| GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0340312509722374 |
| GO:0031988 | membrane-bound vesicle | 0.0340312509722374 |
| GO:0007612 | learning | 0.0340312509722374 |
| GO:0019717 | synaptosome | 0.0340312509722374 |
| GO:0040014 | regulation of multicellular organism growth | 0.0340312509722374 |
| GO:0008283 | cell proliferation | 0.0340312509722374 |
| GO:0006021 | inositol biosynthetic process | 0.0340312509722374 |
| GO:0005148 | prolactin receptor binding | 0.0340312509722374 |
| GO:0043647 | inositol phosphate metabolic process | 0.0340312509722374 |
| GO:0032957 | inositol trisphosphate metabolic process | 0.0340312509722374 |
| GO:0005131 | growth hormone receptor binding | 0.0340312509722374 |
| GO:0060133 | somatotropin secreting cell development | 0.0340312509722374 |
| GO:0035264 | multicellular organism growth | 0.0340312509722374 |
| GO:0007611 | learning and/or memory | 0.0404508747914723 |
| GO:0060126 | somatotropin secreting cell differentiation | 0.0404508747914723 |
| GO:0007262 | STAT protein nuclear translocation | 0.0404508747914723 |
| GO:0001101 | response to acid | 0.0404508747914723 |
| GO:0033143 | regulation of steroid hormone receptor signaling pathway | 0.0404508747914723 |
| GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway | 0.0404508747914723 |
| GO:0060011 | Sertoli cell proliferation | 0.0466662557784434 |
| GO:0045913 | positive regulation of carbohydrate metabolic process | 0.0466662557784434 |
| GO:0050811 | GABA receptor binding | 0.0466662557784434 |
| GO:0043255 | regulation of carbohydrate biosynthetic process | 0.0466662557784434 |
| GO:0031410 | cytoplasmic vesicle | 0.0466662557784434 |
| GO:0005515 | protein binding | 0.0466662557784434 |
| GO:0031982 | vesicle | 0.0474248118340476 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| pituitary gland | 6.68e-44 | 8 |
| gland of diencephalon | 6.68e-44 | 8 |
| neuroendocrine gland | 6.68e-44 | 8 |
| diencephalon | 2.37e-35 | 10 |
| future diencephalon | 2.37e-35 | 10 |
| regional part of forebrain | 9.26e-10 | 39 |
| forebrain | 9.26e-10 | 39 |
| future forebrain | 9.26e-10 | 39 |
| anterior neural tube | 1.55e-09 | 40 |
| regional part of brain | 2.15e-08 | 46 |
| brain | 3.12e-08 | 47 |
| future brain | 3.12e-08 | 47 |
| pre-chordal neural plate | 6.29e-08 | 49 |
| neural tube | 1.63e-07 | 52 |
| neural rod | 1.63e-07 | 52 |
| future spinal cord | 1.63e-07 | 52 |
| neural keel | 1.63e-07 | 52 |
| regional part of nervous system | 2.91e-07 | 54 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
