MCL coexpression mm9:2327

Phase1 CAGE Peaks

	Short description
Mm9::chr2:121976646..121976666,+	p@chr2:121976646..121976666 +
Mm9::chr2:121976670..121976684,+	p@chr2:121976670..121976684 +
Mm9::chr2:121976725..121976737,+	p@chr2:121976725..121976737 +
Mm9::chr6:122266100..122266110,+	p@chr6:122266100..122266110 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0018445	prothoracicotrophic hormone activity	0.00449228913991292
GO:0005159	insulin-like growth factor receptor binding	0.00449228913991292
GO:0042612	MHC class I protein complex	0.017062748648705
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	0.017062748648705
GO:0005184	neuropeptide hormone activity	0.017062748648705
GO:0042611	MHC protein complex	0.0202014561708858
GO:0048002	antigen processing and presentation of peptide antigen	0.0218005620889867
GO:0019882	antigen processing and presentation	0.0319593335156635
GO:0005615	extracellular space	0.04875278177454
GO:0005179	hormone activity	0.04875278177454
GO:0044421	extracellular region part	0.04875278177454

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
connective tissue cell	3.58e-14	46
mesenchymal cell	3.58e-14	46
motile cell	1.19e-12	54
hematopoietic cell	6.43e-09	32
hematopoietic oligopotent progenitor cell	6.43e-09	32
hematopoietic stem cell	6.43e-09	32
angioblastic mesenchymal cell	6.43e-09	32
hematopoietic multipotent progenitor cell	6.43e-09	32
somatic cell	7.99e-09	118
hematopoietic lineage restricted progenitor cell	1.94e-08	25
stem cell	2.18e-08	97
animal cell	8.76e-08	115
eukaryotic cell	8.76e-08	115
somatic stem cell	1.00e-07	91
multi fate stem cell	1.00e-07	91
leukocyte	1.49e-07	17
nongranular leukocyte	1.49e-07	17
lymphoid lineage restricted progenitor cell	6.79e-07	12

Uber Anatomy

Ontology term	p-value	n
connective tissue	3.58e-14	46
unilaminar epithelium	4.82e-12	66
endoderm-derived structure	7.92e-11	118
endoderm	7.92e-11	118
presumptive endoderm	7.92e-11	118
digestive system	1.86e-10	116
digestive tract	1.86e-10	116
primitive gut	1.86e-10	116
hemolymphoid system	2.28e-10	48
immune system	2.28e-10	48
gut epithelium	9.45e-10	55
subdivision of digestive tract	1.23e-09	114
trunk mesenchyme	5.62e-09	45
hematopoietic system	5.65e-09	45
blood island	5.65e-09	45
musculoskeletal system	2.00e-08	32
bone marrow	3.27e-08	16
endo-epithelium	1.62e-07	69

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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