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Coexpression cluster:C364

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Full id: C364_CD14_immature_CD14CD16_Aortic_CD4_Reticulocytes_Basophils



Phase1 CAGE Peaks

Hg19::chr10:107445974..107445984,+p1@YWHAZP5
Hg19::chr10:86998558..86998561,+p@chr10:86998558..86998561
+
Hg19::chr11:59844699..59844715,+p1@ENST00000528891
Hg19::chr12:69004707..69004718,+p2@RAP1B
Hg19::chr14:35898950..35898961,+p@chr14:35898950..35898961
+
Hg19::chr15:37110690..37110722,-p1@CSNK1A1P1
Hg19::chr15:45344875..45344879,+p@chr15:45344875..45344879
+
Hg19::chr15:50086217..50086255,+p1@ENST00000558657
Hg19::chr16:22448582..22448637,+p1@ENST00000309865
Hg19::chr16:52689141..52689186,+p1@ENST00000540332
Hg19::chr16:86469492..86469500,-p@chr16:86469492..86469500
-
Hg19::chr17:74533416..74533417,+p@chr17:74533416..74533417
+
Hg19::chr19:42011981..42012002,+p@chr19:42011981..42012002
+
Hg19::chr19:54705025..54705034,+p7@RPS9
Hg19::chr1:24286287..24286326,+p1@PNRC2
Hg19::chr1:247289721..247289729,+p@chr1:247289721..247289729
+
Hg19::chr20:32990563..32990582,-p1@CDC42P1
Hg19::chr2:171608209..171608242,+p1@EIF2S2P4
Hg19::chr2:240497949..240497953,+p@chr2:240497949..240497953
+
Hg19::chr2:87754989..87755007,+p1@LINC00152
Hg19::chr2:87755107..87755119,+p4@LINC00152
Hg19::chr3:72978005..72978023,+p2@FTH1P23
Hg19::chr4:28829856..28829859,+p@chr4:28829856..28829859
+
Hg19::chr6:127676824..127676831,+p1@YWHAZP4
Hg19::chr7:156971838..156971846,+p@chr7:156971838..156971846
+
Hg19::chr7:5938351..5938379,+p2@CCZ1B
p2@CCZ1
Hg19::chr7:72395617..72395665,+p3@POM121
Hg19::chrX:109590174..109590203,-p1@GNG5P2
Hg19::chrX:43887933..43887952,+p@chrX:43887933..43887952
+
Hg19::chrX:63833271..63833273,-p1@YWHAZP7


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell7.53e-38172
angioblastic mesenchymal cell7.53e-38172
hematopoietic oligopotent progenitor cell1.00e-36165
hematopoietic multipotent progenitor cell1.00e-36165
leukocyte7.31e-36140
hematopoietic cell2.00e-33182
hematopoietic lineage restricted progenitor cell9.81e-32124
myeloid cell9.10e-31112
common myeloid progenitor9.10e-31112
myeloid leukocyte3.86e-2876
nongranular leukocyte5.74e-28119
granulocyte monocyte progenitor cell6.09e-2771
myeloid lineage restricted progenitor cell1.91e-2670
CD14-positive, CD16-negative classical monocyte3.69e-2642
classical monocyte3.78e-2545
macrophage dendritic cell progenitor2.05e-2465
monopoietic cell2.71e-2363
monocyte2.71e-2363
monoblast2.71e-2363
promonocyte2.71e-2363
mesenchymal cell1.12e-11358
connective tissue cell4.50e-10365
motile cell1.74e-09390
multi fate stem cell1.12e-07430
stem cell1.33e-07444
somatic stem cell5.16e-07436
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.89e-21102
blood island1.89e-21102
bone marrow2.44e-2180
bone element1.09e-2086
hemolymphoid system2.83e-19112
skeletal element7.85e-17101
skeletal system7.85e-17101
immune system1.62e-12115
connective tissue5.32e-09375


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.