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Coexpression cluster:C2615

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Full id: C2615_Alveolar_Renal_Urothelial_Tracheal_Keratinocyte_renal_Trabecular



Phase1 CAGE Peaks

Hg19::chr20:361369..361383,+p7@TRIB3
Hg19::chr20:361391..361410,+p2@TRIB3
Hg19::chr20:361478..361491,+p5@TRIB3
Hg19::chr20:361506..361517,+p4@TRIB3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.28e-56254
animal cell9.96e-27679
eukaryotic cell9.96e-27679
embryonic cell1.47e-16248
native cell4.56e-16722
endodermal cell1.66e-1559
squamous epithelial cell6.63e-1262
endo-epithelial cell3.95e-1043
kidney cell2.15e-0818
kidney epithelial cell2.15e-0818
epithelial cell of nephron3.29e-0716
kidney tubule cell6.09e-0712
nephron tubule epithelial cell6.09e-0712
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.40e-18169
endoderm1.40e-18169
presumptive endoderm1.40e-18169
endo-epithelium1.51e-1582
mixed endoderm/mesoderm-derived structure1.19e-14130
digestive system2.59e-14155
digestive tract2.59e-14155
primitive gut2.59e-14155
immaterial anatomical entity5.52e-14126
mesenchyme7.58e-14238
entire embryonic mesenchyme7.58e-14238
trunk5.88e-13216
subdivision of trunk6.93e-13113
foregut3.39e-1298
subdivision of digestive tract5.65e-12129
endodermal part of digestive tract5.65e-12129
primordium1.44e-11168
trunk region element5.05e-11107
gut epithelium1.49e-1054
abdomen element2.33e-0955
abdominal segment element2.33e-0955
urinary system structure2.96e-0944
abdominal segment of trunk3.50e-0961
abdomen3.50e-0961
unilaminar epithelium8.71e-09138
renal system1.36e-0845
anatomical space1.71e-08104
epithelial tube1.92e-08118
exocrine gland4.38e-0831
exocrine system4.38e-0831
epithelium of foregut-midgut junction4.62e-0825
anatomical boundary4.62e-0825
hepatobiliary system4.62e-0825
foregut-midgut junction4.62e-0825
septum transversum4.62e-0825
epithelial sac5.58e-0825
hepatic diverticulum7.22e-0822
liver primordium7.22e-0822
epithelial bud1.30e-0737
gland2.39e-0759
nephron epithelium3.29e-0716
nephron3.29e-0716
uriniferous tubule3.29e-0716
metanephric mesenchyme3.29e-0716
nephrogenic mesenchyme3.29e-0716
sac3.75e-0726
trunk mesenchyme3.80e-07143
respiratory system3.83e-0772
multi-tissue structure4.10e-07347
organism subdivision4.65e-07365
digestive tract diverticulum5.51e-0723
renal tubule6.09e-0712
nephron tubule6.09e-0712
nephron tubule epithelium6.09e-0712
Disease
Ontology termp-valuen
carcinoma1.46e-25106
cell type cancer6.90e-24143
cancer3.31e-23235
disease of cellular proliferation8.64e-22239
disease of anatomical entity7.41e-1039


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467211.23158726300440.01119559039922220.0411304441291813
BHLHE40#8553222.43590677348870.002891464496853120.0156418554121435
CCNT2#90546.336201576962630.0006203100587215640.00512657768638296
CEBPB#105147.971147625824820.0002476385788090830.00268261855951061
CTCF#1066445.360256373075030.001211145381643620.0081791666675382
CTCFL#140690419.74647435897446.5732084880439e-060.00019310810725255
E2F1#186944.907389214879320.001724022357361790.0106579360116318
ELF1#199744.258097958807540.003041525565781240.0161016772386773
ETS1#211349.728760922202340.0001115955317418140.00154656657903175
GABPB1#255335.300762877136630.01012678824234270.0378699383143094
HEY1#2346244.040111043105710.00375304636917980.018625946101063
HMGN3#932448.178547723350590.0002234570284440470.00248272644613488
RAD21#5885410.35503389545638.6948481184721e-050.00129522356674527
SMC3#9126415.04493284493281.95092670935632e-050.000438366683731637
TAF1#687243.343046285745290.008005664898701650.0322570847359376
TBP#690843.706770687096390.005296377814784350.0244528713407127
TCF7L2#6934410.77017656313737.42969445082454e-050.00115520300543347
TFAP2A#7020416.5186343730451.34240829060362e-050.000326806012732754
TFAP2C#7022410.80922860986027.32289634782688e-050.00114627693595727
YY1#752844.911170749853860.00171871838055440.0106935082179627
ZBTB7A#5134147.35190930787590.000342223540015990.00346903661998738
ZEB1#6935416.88843201754391.22862303393937e-050.000304427428331184



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.