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Coexpression cluster:C4466

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Full id: C4466_acute_biphenotypic_Dendritic_Monocytederived_migratory_granulocyte_CD34



Phase1 CAGE Peaks

Hg19::chr5:134787950..134787969,-p2@TIFAB
Hg19::chr5:134787984..134788005,-p4@TIFAB
Hg19::chr5:134788010..134788046,-p1@TIFAB


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
granulocyte monocyte progenitor cell1.37e-4171
macrophage dendritic cell progenitor1.38e-4165
myeloid cell2.91e-41112
common myeloid progenitor2.91e-41112
monopoietic cell3.33e-3963
monocyte3.33e-3963
monoblast3.33e-3963
promonocyte3.33e-3963
myeloid leukocyte2.96e-3876
myeloid lineage restricted progenitor cell6.53e-3870
hematopoietic stem cell4.86e-34172
angioblastic mesenchymal cell4.86e-34172
leukocyte7.46e-32140
hematopoietic cell1.74e-31182
hematopoietic oligopotent progenitor cell2.04e-29165
hematopoietic multipotent progenitor cell2.04e-29165
CD14-positive, CD16-negative classical monocyte9.27e-2642
hematopoietic lineage restricted progenitor cell9.37e-25124
nongranular leukocyte1.43e-24119
classical monocyte3.02e-2345
dendritic cell5.08e-1610
conventional dendritic cell2.66e-138
immature conventional dendritic cell2.16e-095
common dendritic progenitor2.16e-095
Langerhans cell5.23e-085
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.69e-46102
blood island1.69e-46102
hemolymphoid system1.79e-43112
bone marrow1.54e-3680
bone element1.27e-3286
immune system3.47e-30115
skeletal element6.11e-25101
skeletal system6.11e-25101
adult organism2.51e-17115
lateral plate mesoderm7.04e-16216
musculoskeletal system9.45e-12167
blood8.22e-0715
haemolymphatic fluid8.22e-0715
organism substance8.22e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.