MCL coexpression mm9:2748

Phase1 CAGE Peaks

	Short description
Mm9::chr11:97561641..97561663,-	p2@Pcgf2
Mm9::chr4:123089124..123089175,-	p1@D830031N03Rik
Mm9::chr4:123089245..123089260,-	p2@D830031N03Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016573	histone acetylation	0.0121075987508903
GO:0031519	PcG protein complex	0.0121075987508903
GO:0006473	protein amino acid acetylation	0.0121075987508903
GO:0001739	sex chromatin	0.0121075987508903
GO:0000803	sex chromosome	0.0121075987508903
GO:0043543	protein amino acid acylation	0.0147464343760843
GO:0005720	nuclear heterochromatin	0.0147464343760843
GO:0000790	nuclear chromatin	0.0147464343760843
GO:0016570	histone modification	0.0147464343760843
GO:0000792	heterochromatin	0.0147464343760843
GO:0016569	covalent chromatin modification	0.0147464343760843
GO:0016604	nuclear body	0.0147464343760843
GO:0044454	nuclear chromosome part	0.0240002697133032
GO:0000228	nuclear chromosome	0.0259448544661934
GO:0009952	anterior/posterior pattern formation	0.0288137566427437
GO:0003682	chromatin binding	0.0288137566427437
GO:0003002	regionalization	0.0402673533117844
GO:0016568	chromatin modification	0.0426870468781387
GO:0000785	chromatin	0.047302966779794

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
cardiovascular system	9.96e-13	23
circulatory system	9.96e-13	23
primary circulatory organ	9.18e-11	18
heart	9.18e-11	18
primitive heart tube	9.18e-11	18
primary heart field	9.18e-11	18
anterior lateral plate mesoderm	9.18e-11	18
heart tube	9.18e-11	18
heart primordium	9.18e-11	18
cardiac mesoderm	9.18e-11	18
cardiogenic plate	9.18e-11	18
heart rudiment	9.18e-11	18
splanchnic layer of lateral plate mesoderm	2.56e-09	33
lung	2.91e-08	14
respiratory tube	2.91e-08	14
respiration organ	2.91e-08	14
pair of lungs	2.91e-08	14
lung primordium	2.91e-08	14
lung bud	2.91e-08	14
multi-cellular organism	1.68e-07	333
anatomical space	3.37e-07	57
epithelial bud	3.95e-07	17
epithelial fold	5.00e-07	20
thoracic cavity element	8.06e-07	17
thoracic segment organ	8.06e-07	17
thoracic cavity	8.06e-07	17
thoracic segment of trunk	8.06e-07	17
respiratory primordium	8.06e-07	17
endoderm of foregut	8.06e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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