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Coexpression cluster:C1881

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Full id: C1881_Mast_CD14_CD8_Neutrophils_CD4_seminal_CD19



Phase1 CAGE Peaks

Hg19::chr2:157186310..157186350,-p10@NR4A2
Hg19::chr2:157186607..157186620,-p13@NR4A2
Hg19::chr2:157186630..157186686,-p6@NR4A2
Hg19::chr2:157189101..157189111,-p15@NR4A2
Hg19::chrX:110924548..110924560,+p7@ALG13


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004577N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity0.00600494524902861
GO:0042053regulation of dopamine metabolic process0.00750573964426472
GO:0042069regulation of catecholamine metabolic process0.00750573964426472
GO:0030259lipid glycosylation0.00750573964426472
GO:0042417dopamine metabolic process0.0132089351129703
GO:0006584catecholamine metabolic process0.0231530680820022
GO:0018958phenol metabolic process0.0231530680820022
GO:0042133neurotransmitter metabolic process0.0240088214539921
GO:0008375acetylglucosaminyltransferase activity0.0300052818962163
GO:0030258lipid modification0.0312022760161516
GO:0006576biogenic amine metabolic process0.0389879082248776
GO:0001505regulation of neurotransmitter levels0.0389879082248776
GO:0006575amino acid derivative metabolic process0.0415182401034486



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.50e-24136
classical monocyte5.56e-2442
CD14-positive, CD16-negative classical monocyte5.56e-2442
myeloid leukocyte1.16e-2372
defensive cell1.85e-1948
phagocyte1.85e-1948
granulocyte monocyte progenitor cell1.97e-1967
hematopoietic lineage restricted progenitor cell4.56e-18120
myeloid lineage restricted progenitor cell2.74e-1766
hematopoietic stem cell8.82e-17168
angioblastic mesenchymal cell8.82e-17168
hematopoietic cell9.08e-17177
macrophage dendritic cell progenitor7.69e-1661
nongranular leukocyte9.35e-16115
hematopoietic oligopotent progenitor cell4.28e-15161
hematopoietic multipotent progenitor cell4.28e-15161
monopoietic cell2.95e-1459
monocyte2.95e-1459
monoblast2.95e-1459
promonocyte2.95e-1459
myeloid cell6.80e-14108
common myeloid progenitor6.80e-14108
stuff accumulating cell1.61e-0887
CD4-positive, alpha-beta T cell7.27e-086
granulocyte1.24e-078
histamine secreting cell6.31e-075
biogenic amine secreting cell6.31e-075
granulocytopoietic cell6.31e-075
mast cell6.31e-075
mast cell progenitor6.31e-075
basophil mast progenitor cell6.31e-075
circulating cell7.09e-076
Uber Anatomy
Ontology termp-valuen
bone marrow1.41e-1676
hematopoietic system1.81e-1698
blood island1.81e-1698
bone element1.86e-1582
hemolymphoid system4.04e-14108
skeletal element1.36e-1390
immune system2.96e-1393
skeletal system4.93e-13100


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.