Personal tools

Coexpression cluster:C3975

From FANTOM5_SSTAR

Revision as of 15:33, 19 October 2012 by Autoedit (talk | contribs)
Jump to: navigation, search


Full id: C3975_Urothelial_Keratinocyte_amniotic_Corneal_epidermoid_Prostate_papillotubular



Phase1 CAGE Peaks

Hg19::chr1:35225339..35225343,+p1@GJB4
Hg19::chr6:35360230..35360249,+p@chr6:35360230..35360249
+
Hg19::chr6:35360512..35360523,+p@chr6:35360512..35360523
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
respiratory epithelial cell1.12e-2313
endo-epithelial cell1.16e-2242
epithelial cell6.61e-20253
endodermal cell8.31e-1558
general ecto-epithelial cell1.42e-1414
epithelial cell of tracheobronchial tree2.45e-149
epithelial cell of lower respiratory tract2.45e-149
transitional epithelial cell2.36e-124
urothelial cell2.36e-124
bronchial epithelial cell3.21e-093
duct epithelial cell4.32e-093
branched duct epithelial cell4.32e-093
tracheal epithelial cell4.32e-093
tracheoblast4.32e-093
gingival epithelial cell9.58e-093
epidermal cell1.45e-079
ecto-epithelial cell1.74e-0734
stratified squamous epithelial cell1.80e-076
keratin accumulating cell1.80e-076
stratified epithelial cell1.80e-076
keratinizing barrier epithelial cell1.80e-076
epithelial fate stem cell1.80e-076
stratified epithelial stem cell1.80e-076
surface ectodermal cell1.80e-076
corneal epithelial cell7.45e-072
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure3.15e-15160
endoderm3.15e-15160
presumptive endoderm3.15e-15160
urinary system structure1.36e-1147
renal system2.91e-1148
tracheobronchial tree2.91e-1015
lower respiratory tract2.91e-1015
respiratory system3.94e-1074
urothelium7.40e-105
lower respiratory tract epithelium3.21e-093
epithelium of bronchus3.21e-093
endo-epithelium8.01e-0982
gingival epithelium9.58e-093
digestive system1.25e-08145
digestive tract1.25e-08145
primitive gut1.25e-08145
respiratory tract1.37e-0854
transitional epithelium3.44e-086
epithelial fold1.09e-0747
organism subdivision1.53e-07264
epithelial bud1.81e-0737
thoracic cavity element3.19e-0734
thoracic cavity3.19e-0734
surface structure4.32e-0799
thoracic segment organ5.97e-0735
embryo7.48e-07592
developing anatomical structure8.86e-07581


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ESR1#2099220.51240219743630.003099741577095180.016312300240363
NR3C1#290829.982015554115360.01278474365547170.0460486219697134



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.