MCL coexpression mm9:1226

Phase1 CAGE Peaks

	Short description
Mm9::chr10:12728248..12728325,+	p1@Sf3b5
Mm9::chr13:34254822..34254902,+	p1@Psmg4
Mm9::chr15:78971754..78971788,+	p1@Polr2f
Mm9::chr2:130005046..130005112,-	p1@Snrpb
Mm9::chr7:133839456..133839523,+	p1@Bola2
Mm9::chr8:72655226..72655291,+	p1@Nr2c2ap

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005681	spliceosome	0.00661407924265768
GO:0008380	RNA splicing	0.00661407924265768
GO:0006397	mRNA processing	0.00688011728768921
GO:0016071	mRNA metabolic process	0.00688011728768921
GO:0006396	RNA processing	0.00993700490759503
GO:0032991	macromolecular complex	0.00993700490759503
GO:0030529	ribonucleoprotein complex	0.0107381397348516
GO:0016070	RNA metabolic process	0.0107381397348516
GO:0030880	RNA polymerase complex	0.0113878965286287
GO:0010467	gene expression	0.0147241541606693
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0179963855922899
GO:0003899	DNA-directed RNA polymerase activity	0.0223120998489921
GO:0044428	nuclear part	0.0303298318377121
GO:0005634	nucleus	0.0342785404752569
GO:0043283	biopolymer metabolic process	0.0350646740319669

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
animal cell	2.80e-35	115
eukaryotic cell	2.80e-35	115
somatic cell	5.73e-34	118
stem cell	7.76e-30	97
somatic stem cell	5.37e-27	91
multi fate stem cell	5.37e-27	91
motile cell	1.60e-25	54
connective tissue cell	6.09e-21	46
mesenchymal cell	6.09e-21	46
hematopoietic cell	2.44e-16	32
hematopoietic oligopotent progenitor cell	2.44e-16	32
hematopoietic stem cell	2.44e-16	32
angioblastic mesenchymal cell	2.44e-16	32
hematopoietic multipotent progenitor cell	2.44e-16	32
hematopoietic lineage restricted progenitor cell	2.06e-12	25
embryonic cell	2.53e-12	70
non-terminally differentiated cell	9.35e-11	49
common myeloid progenitor	1.06e-10	19
ectodermal cell	2.08e-09	44
neurectodermal cell	2.08e-09	44
leukocyte	3.54e-09	17
nongranular leukocyte	3.54e-09	17
neural cell	3.76e-09	43
myeloid cell	7.10e-09	16
nucleate cell	1.99e-08	16
myeloid lineage restricted progenitor cell	4.30e-07	13
lymphocyte	8.51e-07	13
common lymphoid progenitor	8.51e-07	13

Uber Anatomy

Ontology term	p-value	n
connective tissue	6.09e-21	46
bone marrow	2.89e-09	16
hematopoietic system	2.20e-08	45
blood island	2.20e-08	45
hemolymphoid system	4.03e-08	48
immune system	4.03e-08	48

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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