MCL coexpression mm9:3560

Phase1 CAGE Peaks

	Short description
Mm9::chr6:38059320..38059402,+	p1@Tmem213
Mm9::chr6:38059408..38059417,+	p2@Tmem213
Mm9::chr6:38059548..38059574,-	p6@Atp6v0a4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016471	vacuolar proton-transporting V-type ATPase complex	0.00679340382402893
GO:0033176	proton-transporting V-type ATPase complex	0.00679340382402893
GO:0015991	ATP hydrolysis coupled proton transport	0.00679340382402893
GO:0015988	energy coupled proton transport, against electrochemical gradient	0.00679340382402893
GO:0005774	vacuolar membrane	0.0101901057360434
GO:0044437	vacuolar part	0.0101901057360434
GO:0005903	brush border	0.0101901057360434
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	0.0101901057360434
GO:0016469	proton-transporting two-sector ATPase complex	0.013964218971615
GO:0015992	proton transport	0.0169835095600723
GO:0006818	hydrogen transport	0.0169835095600723
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	0.0169835095600723
GO:0045177	apical part of cell	0.0196523467766551
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	0.0196523467766551
GO:0015078	hydrogen ion transmembrane transporter activity	0.0202258159306316
GO:0015077	monovalent inorganic cation transmembrane transporter activity	0.0202258159306316
GO:0043492	ATPase activity, coupled to movement of substances	0.0202258159306316
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	0.0202258159306316
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.0202258159306316
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.0202258159306316
GO:0015399	primary active transmembrane transporter activity	0.0202258159306316
GO:0022890	inorganic cation transmembrane transporter activity	0.0202258159306316
GO:0005773	vacuole	0.0282073941389027
GO:0042623	ATPase activity, coupled	0.0318440804251356
GO:0016887	ATPase activity	0.035461567961431
GO:0015672	monovalent inorganic cation transport	0.0373637210321591
GO:0022804	active transmembrane transporter activity	0.0396281889735021
GO:0042995	cell projection	0.044157124856188
GO:0017111	nucleoside-triphosphatase activity	0.0472541177759659
GO:0008324	cation transmembrane transporter activity	0.0472541177759659
GO:0006812	cation transport	0.0472541177759659
GO:0016462	pyrophosphatase activity	0.0472541177759659
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0472541177759659
GO:0016817	hydrolase activity, acting on acid anhydrides	0.0472541177759659

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
kidney	8.20e-13	14
kidney mesenchyme	8.20e-13	14
upper urinary tract	8.20e-13	14
kidney rudiment	8.20e-13	14
kidney field	8.20e-13	14
renal system	1.98e-11	19
urinary system structure	1.94e-10	18
lung	1.95e-10	14
respiratory tube	1.95e-10	14
respiration organ	1.95e-10	14
pair of lungs	1.95e-10	14
lung primordium	1.95e-10	14
lung bud	1.95e-10	14
epithelial bud	5.31e-08	17
thoracic cavity element	5.31e-08	17
thoracic segment organ	5.31e-08	17
thoracic cavity	5.31e-08	17
thoracic segment of trunk	5.31e-08	17
respiratory primordium	5.31e-08	17
endoderm of foregut	5.31e-08	17
cavitated compound organ	2.78e-07	21

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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