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Coexpression cluster:C839

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Full id: C839_Retinal_Mallassezderived_retina_medulla_mesothelioma_osteosarcoma_Saos2



Phase1 CAGE Peaks

Hg19::chr16:68301840..68301845,+p@chr16:68301840..68301845
+
Hg19::chr17:932596..932605,-p@chr17:932596..932605
-
Hg19::chr19:32863977..32863981,-p@chr19:32863977..32863981
-
Hg19::chr1:147150847..147150854,-p@chr1:147150847..147150854
-
Hg19::chr22:41734286..41734290,+p@chr22:41734286..41734290
+
Hg19::chr22:50740068..50740112,-p3@PLXNB2
Hg19::chr2:20796228..20796230,+p@chr2:20796228..20796230
+
Hg19::chr2:235591286..235591298,+p@chr2:235591286..235591298
+
Hg19::chr2:235591306..235591328,+p@chr2:235591306..235591328
+
Hg19::chr2:27431534..27431545,-p@chr2:27431534..27431545
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
retinal pigment epithelial cell2.40e-553
visual pigment cell9.63e-424
mucus secreting cell2.25e-191
pigment cell1.86e-1214
seromucus secreting cell2.27e-102
metabolising cell7.15e-0712
endopolyploid cell7.15e-0712
parenchymal cell7.15e-0712
polyploid cell7.15e-0712
hepatocyte7.15e-0712
Uber Anatomy
Ontology termp-valuen
pigmented layer of retina2.40e-553
presumptive retinal pigmented epithelium2.40e-553
retina6.63e-496
photoreceptor array6.63e-496
posterior segment of eyeball6.63e-496
layer of retina9.63e-424
medulla oblongata1.14e-243
myelencephalon1.14e-243
future myelencephalon1.14e-243
eye7.93e-2221
visual system7.93e-2221
sense organ4.01e-1924
sensory system4.01e-1924
entire sense organ system4.01e-1924
pigment epithelium of eye1.13e-1511
camera-type eye5.17e-1520
simple eye5.17e-1520
immature eye5.17e-1520
ocular region5.17e-1520
eyeball of camera-type eye5.17e-1520
optic cup5.17e-1520
optic vesicle5.17e-1520
eye primordium5.17e-1520
face1.11e-1322
brainstem7.33e-136
ectodermal placode8.32e-1031
neural plate9.94e-0882
presumptive neural plate9.94e-0882
neurectoderm2.31e-0786
segmental subdivision of hindbrain6.94e-0712
hindbrain6.94e-0712
presumptive hindbrain6.94e-0712
Disease
Ontology termp-valuen
mucinous adenocarcinoma2.25e-191


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00834483
MA0004.10.380329
MA0006.10.236135
MA0007.10.363007
MA0009.10.828613
MA0014.10.0679667
MA0017.10.744788
MA0019.10.520264
MA0024.10.725404
MA0025.10.960689
MA0027.12.43535
MA0028.10.25013
MA0029.10.744375
MA0030.10.733118
MA0031.10.669876
MA0038.10.477043
MA0040.10.750125
MA0041.10.397617
MA0042.10.367902
MA0043.10.828925
MA0046.10.817858
MA0048.10.0613414
MA0050.10.368721
MA0051.10.473017
MA0052.10.753928
MA0055.10.0662377
MA0056.10
MA0057.10.211138
MA0058.10.293055
MA0059.10.291897
MA0060.10.430116
MA0061.10.377096
MA0063.10
MA0066.10.477449
MA0067.11.1435
MA0068.10.0911063
MA0069.10.814052
MA0070.10.803003
MA0071.11.12112
MA0072.10.798564
MA0073.10.575522
MA0074.10.4723
MA0076.10.307383
MA0077.11.85814
MA0078.10.568317
MA0081.10.292043
MA0083.10.836033
MA0084.11.32998
MA0087.10.79615
MA0088.10.126492
MA0089.10
MA0090.10.320494
MA0091.10.382762
MA0092.10.918839
MA0093.10.671378
MA0095.10
MA0098.10
MA0100.10.49029
MA0101.10.678051
MA0103.10.646502
MA0105.10.189717
MA0106.10.516528
MA0107.10.179177
MA0108.21.6011
MA0109.10
MA0111.10.885497
MA0113.10.532314
MA0114.11.5848
MA0115.11.06753
MA0116.10.536665
MA0117.10.865782
MA0119.10.760742
MA0122.10.891407
MA0124.11.0263
MA0125.10.942948
MA0130.10
MA0131.10.585907
MA0132.10
MA0133.10
MA0135.10.858623
MA0136.10.483775
MA0139.10.353333
MA0140.10.437738
MA0141.10.290336
MA0142.10.638837
MA0143.10.532484
MA0144.10.491079
MA0145.10.602634
MA0146.10.4029
MA0147.10.184931
MA0148.10.403564
MA0149.10.428597
MA0062.20.114378
MA0035.20.437071
MA0039.20.233545
MA0138.20.569505
MA0002.21.90479
MA0137.20.255808
MA0104.20.138396
MA0047.20.504873
MA0112.20.0329985
MA0065.20.615279
MA0150.10.845871
MA0151.10
MA0152.10.443956
MA0153.10.926242
MA0154.12.09876
MA0155.10.12484
MA0156.10.257809
MA0157.10.612166
MA0158.10
MA0159.10.185458
MA0160.10.417847
MA0161.10
MA0162.10.0377269
MA0163.10.299639
MA0164.10.544294
MA0080.20.238846
MA0018.20.517858
MA0099.21.12985
MA0079.20.0313405
MA0102.21.36707
MA0258.10.155735
MA0259.10.191914
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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