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Coexpression cluster:C3346

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Full id: C3346_Endothelial_Renal_somatostatinoma_Lymphatic_Small_Fibroblast_Natural



Phase1 CAGE Peaks

Hg19::chr12:96028776..96028781,-p@chr12:96028776..96028781
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Hg19::chr5:106837869..106837878,-p@chr5:106837869..106837878
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Hg19::chr5:106837881..106837888,-p@chr5:106837881..106837888
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
endothelial cell of vascular tree1.60e-5724
endothelial cell2.90e-5336
meso-epithelial cell2.58e-4245
blood vessel endothelial cell1.27e-4018
embryonic blood vessel endothelial progenitor cell1.27e-4018
capillary endothelial cell1.85e-363
lining cell1.74e-3258
barrier cell1.74e-3258
lymphangioblast1.84e-186
endothelial cell of lymphatic vessel1.84e-186
vascular lymphangioblast1.84e-186
vein endothelial cell6.69e-186
endothelial cell of umbilical vein2.20e-163
mesodermal cell1.04e-14121
peptide hormone secreting cell2.32e-131
enteroendocrine cell2.32e-131
type D enteroendocrine cell2.32e-131
somatostatin secreting cell2.32e-131
pancreatic D cell2.32e-131
progenitor cell of endocrine pancreas2.32e-131
epithelial cell of nephron1.18e-1215
kidney cell3.41e-1117
kidney epithelial cell3.41e-1117
squamous epithelial cell4.72e-1163
fenestrated cell1.95e-105
glomerular endothelial cell1.95e-105
epithelial cell6.93e-10253
kidney cortical cell2.26e-0912
renal cortical epithelial cell2.26e-0912
glomerular cell1.06e-077
kidney corpuscule cell1.06e-077
Uber Anatomy
Ontology termp-valuen
blood vessel endothelium1.27e-4018
endothelium1.27e-4018
cardiovascular system endothelium1.27e-4018
microcirculatory vessel1.85e-363
endothelium of capillary1.85e-363
capillary1.85e-363
simple squamous epithelium4.07e-3322
squamous epithelium4.64e-2925
vessel1.82e-1968
vasculature8.62e-1778
vascular system8.62e-1778
lymphatic vessel5.28e-148
lymph vasculature5.28e-148
lymphatic part of lymphoid system5.28e-148
epithelial tube9.13e-13117
nephron epithelium1.18e-1215
renal tubule1.18e-1215
nephron tubule1.18e-1215
nephron1.18e-1215
uriniferous tubule1.18e-1215
nephrogenic mesenchyme1.18e-1215
vein3.83e-129
venous blood vessel3.83e-129
venous system3.83e-129
excretory tube7.05e-1216
kidney epithelium7.05e-1216
epithelial tube open at both ends7.36e-1259
blood vessel7.36e-1259
blood vasculature7.36e-1259
vascular cord7.36e-1259
cardiovascular system1.32e-11109
lymphoid system2.55e-1110
circulatory system2.96e-11112
umbilical vein3.27e-105
cortex of kidney2.26e-0912
renal parenchyma2.26e-0912
anatomical conduit5.39e-09240
splanchnic layer of lateral plate mesoderm3.53e-0883
primitive nephron1.06e-077
renal glomerulus1.06e-077
renal corpuscle1.06e-077
glomerular capsule1.06e-077
metanephric mesenchyme1.06e-077
glomerular tuft1.06e-077
S-shaped body1.06e-077
renal vesicle1.06e-077
comma-shaped body1.06e-077
cortex1.34e-0715
parenchyma1.34e-0715
kidney2.17e-0726
kidney mesenchyme2.17e-0726
upper urinary tract2.17e-0726
kidney rudiment2.17e-0726
kidney field2.17e-0726
tube4.42e-07192
mesonephric epithelium7.66e-078
mesonephric tubule7.66e-078
nephric duct7.66e-078
renal duct7.66e-078
mesonephric duct7.66e-078
pronephric duct7.66e-078
Disease
Ontology termp-valuen
somatostatinoma2.32e-131


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203336.77394172622320.003216880500103790.0167098270441828
FOS#235338.99795530889440.001372499272417130.00895722374004703
GATA2#2624312.7449317335540.0004829527704283790.00436324432446103
JUN#3725312.51282919233630.0005103313992726250.00443488941659458



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.