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Coexpression cluster:C4751

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Full id: C4751_Mast_Eosinophils_Neutrophils_granulocyte_Dendritic_mucinous_Smooth



Phase1 CAGE Peaks

Hg19::chr8:38644715..38644732,+p2@TACC1
Hg19::chr8:38644746..38644761,+p1@TACC1
Hg19::chr8:38644778..38644785,+p14@TACC1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.11e-36140
myeloid leukocyte9.20e-3076
hematopoietic lineage restricted progenitor cell7.20e-29124
granulocyte monocyte progenitor cell1.39e-2671
myeloid lineage restricted progenitor cell3.07e-2570
hematopoietic stem cell6.21e-25172
angioblastic mesenchymal cell6.21e-25172
nongranular leukocyte8.77e-25119
hematopoietic cell1.00e-23182
CD14-positive, CD16-negative classical monocyte3.00e-2342
macrophage dendritic cell progenitor6.60e-2365
hematopoietic oligopotent progenitor cell9.84e-23165
hematopoietic multipotent progenitor cell9.84e-23165
monopoietic cell1.03e-2163
monocyte1.03e-2163
monoblast1.03e-2163
promonocyte1.03e-2163
classical monocyte3.99e-1945
myeloid cell3.73e-18112
common myeloid progenitor3.73e-18112
multi fate stem cell1.77e-09430
mesenchymal cell6.12e-09358
motile cell1.42e-08390
connective tissue cell3.09e-08365
somatic stem cell4.58e-08436
stem cell1.43e-07444
Uber Anatomy
Ontology termp-valuen
hemolymphoid system3.80e-29112
hematopoietic system1.14e-27102
blood island1.14e-27102
bone marrow4.12e-2580
bone element1.29e-2286
skeletal element6.12e-20101
skeletal system6.12e-20101
immune system3.90e-19115
lateral plate mesoderm1.69e-16216
musculoskeletal system2.53e-15167
connective tissue4.77e-09375


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.