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Coexpression cluster:C866

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Full id: C866_hairy_CD14_mycosis_cord_Eosinophils_CD14CD16_immature



Phase1 CAGE Peaks

Hg19::chr10:104155680..104155687,+p6@NFKB2
Hg19::chr11:117699420..117699434,-p4@FXYD2
Hg19::chr11:117699438..117699449,-p8@FXYD2
Hg19::chr11:117712764..117712789,-p@chr11:117712764..117712789
-
Hg19::chr20:61077113..61077116,+p@chr20:61077113..61077116
+
Hg19::chr22:24801933..24801943,+p@chr22:24801933..24801943
+
Hg19::chr2:114132562..114132577,-p@chr2:114132562..114132577
-
Hg19::chr6:160411448..160411452,+p@chr6:160411448..160411452
+
Hg19::chr7:45017046..45017066,-p6@MYO1G


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0002266follicular dendritic cell activation0.00551908867851121
GO:0002268follicular dendritic cell differentiation0.00551908867851121
GO:0033257Bcl3/NF-kappaB2 complex0.00551908867851121
GO:0033256I-kappaB/NF-kappaB complex0.00551908867851121
GO:0048536spleen development0.00735835166545414
GO:0002467germinal center formation0.00735835166545414
GO:0043234protein complex0.010903573526755
GO:0005890sodium:potassium-exchanging ATPase complex0.0110362278570225
GO:0032991macromolecular complex0.0187566168636969
GO:0005391sodium:potassium-exchanging ATPase activity0.0187566168636969
GO:0030198extracellular matrix organization and biogenesis0.0460998883929867



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic cell4.37e-46182
hematopoietic stem cell3.81e-45172
angioblastic mesenchymal cell3.81e-45172
hematopoietic oligopotent progenitor cell2.07e-42165
hematopoietic multipotent progenitor cell2.07e-42165
leukocyte7.62e-42140
myeloid cell9.74e-41112
common myeloid progenitor9.74e-41112
myeloid leukocyte2.85e-3776
granulocyte monocyte progenitor cell2.73e-3271
hematopoietic lineage restricted progenitor cell3.42e-32124
macrophage dendritic cell progenitor1.11e-3165
nongranular leukocyte3.11e-31119
myeloid lineage restricted progenitor cell3.62e-3170
CD14-positive, CD16-negative classical monocyte3.99e-3142
monopoietic cell2.77e-3063
monocyte2.77e-3063
monoblast2.77e-3063
promonocyte2.77e-3063
classical monocyte1.22e-2945
mesenchymal cell3.62e-15358
connective tissue cell5.60e-14365
motile cell2.10e-12390
multi fate stem cell9.26e-09430
stem cell9.36e-09444
somatic stem cell3.99e-08436
intermediate monocyte2.46e-079
CD14-positive, CD16-positive monocyte2.46e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.35e-30102
blood island1.35e-30102
hemolymphoid system7.62e-29112
bone marrow3.62e-2880
bone element4.64e-2686
immune system1.40e-20115
skeletal element6.45e-20101
skeletal system6.45e-20101
connective tissue1.76e-13375
lateral plate mesoderm3.50e-11216
musculoskeletal system3.69e-07167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.