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CL:0000057

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Name:fibroblast
Namespace:FANTOM
Definition:"A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." ISBN:0517223651, MESH:A.11.329.228
Xrefs:
links:

BTO:0000452

FMA:63877
Comments:These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.


Ontology association

Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.



link to ontology dataset


data

Parents

is_a:CL:0002320(connective tissue cell)
develops_from:CL:0000134(mesenchymal cell)



Children


is a:CL:0000005 (fibroblast neural crest derived),CL:0000632 (hepatic stellate cell),CL:0002334 (preadipocyte),CL:0002548 (cardiac fibroblast),CL:0002549 (fibroblast of choroid plexus),CL:0002550 (fibroblast of the conjuctiva),CL:0002552 (fibroblast of gingiva),CL:0002553 (lung fibroblast),CL:0002554 (fibroblast of lymphatic vessel),CL:0002555 (fibroblast of mammary gland),CL:0002556 (fibroblast of periodontium),CL:0002557 (fibroblast of pulmonary artery),CL:0002558 (fibroblast of villous mesenchyme),CL:0002620 (skin fibroblast),CL:1000306 (fibroblast of tunica adventitia of artery)
derives from:FF:0000057 (fibroblast sample),FF:0000107 (mouse embryonic fibroblast sample),FF:0100453 (fibroblast cell line sample)
develops from:CL:0000135 (fibrocyte)

Ontology Tree: Loaded from BioPortal


FF samples

It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens) Mouse (Mus musculus)



Enrichment analysis: top 100 FFCP enriched with this ontology term
TOP 100 FANTOM5 Cage Peaks enriched with CL:0000057 (fibroblast), sorted by p-values
Analyst: Hideya Kawaji



link to source dataset
human : data

mouse : data

P-valueFFCPShort description
3.07e-86FFCP PHASE1:Mm9::chr2:156282978..156282979,+#_b3a45416708d7941f5fd9feda8878cf3p@chr2:156282978..156282979, +
3.07e-86FFCP PHASE2:Mm9::chr10:94173889..94173890,-#_b3a45416708d7941f5fd9feda8878cf3p@chr10:94173889..94173890, -
3.07e-86FFCP PHASE2:Mm9::chrX:45409736..45409738,+#_b3a45416708d7941f5fd9feda8878cf3p@chrX:45409736..45409738, +
3.07e-86FFCP PHASE1:Mm9::chr10:94173889..94173890,-#_b3a45416708d7941f5fd9feda8878cf3p@chr10:94173889..94173890, -
3.07e-86FFCP PHASE2:Mm9::chr2:156282978..156282979,+#_b3a45416708d7941f5fd9feda8878cf3p@chr2:156282978..156282979, +
3.07e-86FFCP PHASE1:Mm9::chr4:50498164..50498166,+#_b3a45416708d7941f5fd9feda8878cf3p@chr4:50498164..50498166, +
3.07e-86FFCP PHASE1:Mm9::chrX:45409736..45409738,+#_b3a45416708d7941f5fd9feda8878cf3p@chrX:45409736..45409738, +
3.07e-86FFCP PHASE2:Mm9::chr4:50498164..50498166,+#_b3a45416708d7941f5fd9feda8878cf3p@chr4:50498164..50498166, +
3.07e-86FFCP PHASE1:Mm9::chr4:61715146..61715151,-#_b3a45416708d7941f5fd9feda8878cf3p1@Mup20
3.07e-86FFCP PHASE2:Mm9::chr17:15914532..15914535,+#_b3a45416708d7941f5fd9feda8878cf3p@chr17:15914532..15914535, +
3.07e-86FFCP PHASE1:Mm9::chr17:15914532..15914535,+#_b3a45416708d7941f5fd9feda8878cf3p@chr17:15914532..15914535, +
3.07e-86FFCP PHASE2:Mm9::chr4:61715146..61715151,-#_b3a45416708d7941f5fd9feda8878cf3p1@Mup20
8.69e-51FFCP PHASE2:Hg19::chr14:92413727..92413738,-#_652b2b5d8eeceb5aa07b63a8f14b7540p7@FBLN5
8.69e-51FFCP PHASE1:Hg19::chr14:92413727..92413738,-#_652b2b5d8eeceb5aa07b63a8f14b7540p7@FBLN5
4.89e-45FFCP PHASE2:Hg19::chr1:161167199..161167216,+#_2f5eb83338e022f6601eab4dc43b5c2bp2@NDUFS2
4.89e-45FFCP PHASE1:Hg19::chr1:161167199..161167216,+#_2f5eb83338e022f6601eab4dc43b5c2bp2@NDUFS2
8.65e-45FFCP PHASE2:Hg19::chr15:80842610..80842647,-#_6316da597d2c1f5fb15d60f3b7f2a43ap@chr15:80842610..80842647, -
8.65e-45FFCP PHASE1:Hg19::chr15:80842610..80842647,-#_6316da597d2c1f5fb15d60f3b7f2a43ap@chr15:80842610..80842647, -
8.96e-45FFCP PHASE2:Hg19::chr1:240408577..240408596,+#_6f500911c77d07461f3034c8ac5aafc3p4@FMN2
8.96e-45FFCP PHASE1:Hg19::chr1:240408577..240408596,+#_6f500911c77d07461f3034c8ac5aafc3p4@FMN2
4.22e-44FFCP PHASE1:Hg19::chr6:148593425..148593498,+#_9d2ffcdd1a3e9ec1ad43bfc0ff70c447p2@SASH1
4.22e-44FFCP PHASE2:Hg19::chr6:148593425..148593498,+#_9d2ffcdd1a3e9ec1ad43bfc0ff70c447p2@SASH1
7.47e-44FFCP PHASE2:Mm9::chr2:35991779..35991800,-#_4b9eb53154bfec94f8733d365a8d12a9p7@Rbm18
7.47e-44FFCP PHASE2:Mm9::chr19:39390004..39390011,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr19:39390004..39390011, +
7.47e-44FFCP PHASE2:Mm9::chr5:114824802..114824807,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr5:114824802..114824807, +
7.47e-44FFCP PHASE1:Mm9::chr2:35991779..35991800,-#_4b9eb53154bfec94f8733d365a8d12a9p7@Rbm18
7.47e-44FFCP PHASE2:Mm9::chrX:166354085..166354088,+#_4b9eb53154bfec94f8733d365a8d12a9p@chrX:166354085..166354088, +
7.47e-44FFCP PHASE1:Mm9::chr3:127483562..127483571,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr3:127483562..127483571, +
7.47e-44FFCP PHASE2:Mm9::chr18:38702532..38702560,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr18:38702532..38702560, +
7.47e-44FFCP PHASE1:Mm9::chr8:42092122..42092137,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr8:42092122..42092137, -
7.47e-44FFCP PHASE1:Mm9::chr6:31268117..31268151,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr6:31268117..31268151, -
7.47e-44FFCP PHASE1:Mm9::chr11:48686060..48686062,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr11:48686060..48686062, +
7.47e-44FFCP PHASE1:Mm9::chr7:111614187..111614200,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:111614187..111614200, +
7.47e-44FFCP PHASE1:Mm9::chr19:39390004..39390011,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr19:39390004..39390011, +
7.47e-44FFCP PHASE2:Mm9::chr7:111614187..111614200,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:111614187..111614200, +
7.47e-44FFCP PHASE2:Mm9::chr8:42092122..42092137,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr8:42092122..42092137, -
7.47e-44FFCP PHASE2:Mm9::chr11:48686060..48686062,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr11:48686060..48686062, +
7.47e-44FFCP PHASE1:Mm9::chrX:166354085..166354088,+#_4b9eb53154bfec94f8733d365a8d12a9p@chrX:166354085..166354088, +
7.47e-44FFCP PHASE2:Mm9::chr7:129965112..129965151,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:129965112..129965151, +
7.47e-44FFCP PHASE1:Mm9::chr7:129965112..129965151,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr7:129965112..129965151, +
7.47e-44FFCP PHASE2:Mm9::chr6:31268117..31268151,-#_4b9eb53154bfec94f8733d365a8d12a9p@chr6:31268117..31268151, -
7.47e-44FFCP PHASE2:Mm9::chr3:127483562..127483571,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr3:127483562..127483571, +
7.47e-44FFCP PHASE1:Mm9::chr18:38702532..38702560,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr18:38702532..38702560, +
7.47e-44FFCP PHASE1:Mm9::chr5:114824802..114824807,+#_4b9eb53154bfec94f8733d365a8d12a9p@chr5:114824802..114824807, +
2.51e-41FFCP PHASE1:Hg19::chr15:33180498..33180522,-#_223331b813e745267822e9a9d8348dc0p4@FMN1
2.51e-41FFCP PHASE2:Hg19::chr15:33180498..33180522,-#_223331b813e745267822e9a9d8348dc0p4@FMN1
7.15e-41FFCP PHASE2:Hg19::chr14:92413677..92413688,-#_bfa6fb5186e986a4156db62616986005p12@FBLN5
7.15e-41FFCP PHASE1:Hg19::chr14:92413677..92413688,-#_bfa6fb5186e986a4156db62616986005p12@FBLN5
8.81e-41FFCP PHASE2:Hg19::chr1:215179028..215179060,+#_31f0fa2f6fe51571be4070c31c781a7dp9@KCNK2
8.81e-41FFCP PHASE1:Hg19::chr1:215179028..215179060,+#_31f0fa2f6fe51571be4070c31c781a7dp9@KCNK2
3.67e-40FFCP PHASE2:Hg19::chr1:215178636..215178662,+#_9283ec5782d941e7579bf126f7d62d3ep5@KCNK2
3.67e-40FFCP PHASE1:Hg19::chr1:215178636..215178662,+#_9283ec5782d941e7579bf126f7d62d3ep5@KCNK2
4.28e-38FFCP PHASE1:Hg19::chr19:10928326..10928342,-#_f6e700b9aee4b1563bdd0fe0360c6ac8p1@MIR199A1
4.28e-38FFCP PHASE2:Hg19::chr19:10928326..10928342,-#_f6e700b9aee4b1563bdd0fe0360c6ac8p1@MIR199A1
6.13e-38FFCP PHASE1:Hg19::chr18:52969844..52969895,-#_5ce9506676de1d63c543c4032228d6d6p27@TCF4
6.13e-38FFCP PHASE2:Hg19::chr18:52969844..52969895,-#_5ce9506676de1d63c543c4032228d6d6p27@TCF4
1.61e-37FFCP PHASE1:Hg19::chr15:81201549..81201567,+#_50583cd4c438ca9abe78181fe26a438fp2@KIAA1199
1.61e-37FFCP PHASE2:Hg19::chr15:81201549..81201567,+#_50583cd4c438ca9abe78181fe26a438fp2@KIAA1199
2.86e-37FFCP PHASE1:Hg19::chr12:78334695..78334719,+#_c4e272da707ff320324de8bf7bb90388p@chr12:78334695..78334719, +
2.86e-37FFCP PHASE2:Hg19::chr12:78334695..78334719,+#_c4e272da707ff320324de8bf7bb90388p@chr12:78334695..78334719, +
4.22e-37FFCP PHASE2:Hg19::chr13:45289884..45289918,-#_6d5f155b5b500bb3b2168c4a42520658p@chr13:45289884..45289918, -
4.22e-37FFCP PHASE1:Hg19::chr13:45289884..45289918,-#_6d5f155b5b500bb3b2168c4a42520658p@chr13:45289884..45289918, -
6.18e-37FFCP PHASE2:Hg19::chr2:239756536..239756564,-#_45acdc479bc4426efea8a871454678efp1@BC143627
6.18e-37FFCP PHASE1:Hg19::chr2:239756536..239756564,-#_45acdc479bc4426efea8a871454678efp1@BC143627
6.63e-37FFCP PHASE2:Hg19::chr1:215178944..215178967,+#_674e775e220d0a8c4de58f42516654d7p11@KCNK2
6.63e-37FFCP PHASE1:Hg19::chr1:215178944..215178967,+#_674e775e220d0a8c4de58f42516654d7p11@KCNK2
6.76e-37FFCP PHASE2:Hg19::chr14:92413764..92413794,-#_76a3e271fc520aa8c9a22ea0cb99c519p2@FBLN5
6.76e-37FFCP PHASE1:Hg19::chr14:92413764..92413794,-#_76a3e271fc520aa8c9a22ea0cb99c519p2@FBLN5
1.13e-36FFCP PHASE2:Hg19::chr12:108991778..108991800,-#_31f1533ce9eaeed933486287845d2b19p2@TMEM119
1.13e-36FFCP PHASE1:Hg19::chr12:108991778..108991800,-#_31f1533ce9eaeed933486287845d2b19p2@TMEM119
1.92e-36FFCP PHASE2:Hg19::chr6:52441791..52441804,-#_514bb67a6e856f84efa086406221fc02p3@TRAM2
1.92e-36FFCP PHASE1:Hg19::chr6:52441791..52441804,-#_514bb67a6e856f84efa086406221fc02p3@TRAM2
3.45e-36FFCP PHASE2:Hg19::chr6:52441770..52441784,-#_1b8a4a599ed128c36fe0d6cae49ef512p2@TRAM2
3.45e-36FFCP PHASE1:Hg19::chr6:52441770..52441784,-#_1b8a4a599ed128c36fe0d6cae49ef512p2@TRAM2
4.74e-36FFCP PHASE2:Hg19::chr2:238322983..238323006,-#_3a32d70f20211eb08b0a7d38d336fc29p4@COL6A3
4.74e-36FFCP PHASE1:Hg19::chr2:238322983..238323006,-#_3a32d70f20211eb08b0a7d38d336fc29p4@COL6A3
5.54e-36FFCP PHASE2:Hg19::chr21:47518695..47518709,+#_d530f61b9a748918517003c9480626bap6@COL6A2
5.54e-36FFCP PHASE1:Hg19::chr21:47518695..47518709,+#_d530f61b9a748918517003c9480626bap6@COL6A2
1.05e-35FFCP PHASE1:Hg19::chr19:50031567..50031632,+#_125dc473df089cf4efe37ca0de76efa8p2@RCN3
1.05e-35FFCP PHASE2:Hg19::chr19:50031567..50031632,+#_125dc473df089cf4efe37ca0de76efa8p2@RCN3
2.16e-35FFCP PHASE2:Hg19::chr15:39410918..39410942,-#_b7861d091c45516728a2d7ae943b212ap1@ENST00000560197
2.16e-35FFCP PHASE1:Hg19::chr15:39410918..39410942,-#_b7861d091c45516728a2d7ae943b212ap1@ENST00000560197
2.63e-35FFCP PHASE1:Hg19::chr1:198636258..198636278,-#_914826195842a37f1825d32f0cc6639dp1@ENST00000413577
2.63e-35FFCP PHASE2:Hg19::chr1:198636258..198636278,-#_914826195842a37f1825d32f0cc6639dp1@ENST00000413577
3.83e-35FFCP PHASE2:Hg19::chr2:239756739..239756755,+#_de1acb1908db33af4757fb4c84aee10cp2@TWIST2
3.83e-35FFCP PHASE1:Hg19::chr2:239756739..239756755,+#_de1acb1908db33af4757fb4c84aee10cp2@TWIST2
6.05e-35FFCP PHASE2:Hg19::chr14:92413748..92413762,-#_3cf355da3268a924da3f621073a47d6ap1@FBLN5
6.05e-35FFCP PHASE1:Hg19::chr14:92413748..92413762,-#_3cf355da3268a924da3f621073a47d6ap1@FBLN5
7.69e-35FFCP PHASE1:Hg19::chr7:135433488..135433499,-#_26f051acefa60761b55e866e39ab9808p2@FAM180A
7.69e-35FFCP PHASE2:Hg19::chr7:135433488..135433499,-#_26f051acefa60761b55e866e39ab9808p2@FAM180A
8.37e-35FFCP PHASE2:Hg19::chr2:238289803..238289845,-#_23a23247f02f5503ea6c21917ed87422p@chr2:238289803..238289845, -
8.37e-35FFCP PHASE1:Hg19::chr2:238289803..238289845,-#_23a23247f02f5503ea6c21917ed87422p@chr2:238289803..238289845, -
1.04e-34FFCP PHASE2:Hg19::chr9:132461010..132461045,+#_2e24cf9d35dfe8c7fcab876885a1abe1p@chr9:132461010..132461045, +
1.04e-34FFCP PHASE1:Hg19::chr9:132461010..132461045,+#_2e24cf9d35dfe8c7fcab876885a1abe1p@chr9:132461010..132461045, +
1.22e-34FFCP PHASE1:Hg19::chr11:35547572..35547588,-#_456bb89cc8a0ecb1813d433e6a85f10ep3@PAMR1
1.22e-34FFCP PHASE2:Hg19::chr11:35547572..35547588,-#_456bb89cc8a0ecb1813d433e6a85f10ep3@PAMR1
1.75e-34FFCP PHASE1:Hg19::chr17:78808278..78808309,-#_8983870ba71748727843959ecc883884p@chr17:78808278..78808309, -
1.75e-34FFCP PHASE2:Hg19::chr17:78808278..78808309,-#_8983870ba71748727843959ecc883884p@chr17:78808278..78808309, -
1.82e-34FFCP PHASE1:Hg19::chr11:66082890..66082979,+#_61a74ab8cb62cb6c2739c8fd01724bbap@chr11:66082890..66082979, +
1.82e-34FFCP PHASE2:Hg19::chr11:66082890..66082979,+#_61a74ab8cb62cb6c2739c8fd01724bbap@chr11:66082890..66082979, +