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|created_by=
|created_by=
|creation_date=
|creation_date=
|data_phase=1
|data_phase=2
|datafreeze_phase=1
|datafreeze_phase=2
|def=
|def=
|expression_enrichment_score=chr2:68592406..68592424,+!p1@PLEK!2.35!220.79!PLEK;;chr11:47400078..47400106,-!p1@SPI1!2.16!145.17!SPI1;;chr1:92949331..92949377,-!p2@GFI1!2.01!100.23!GFI1;;chr7:50344289..50344323,+!p1@IKZF1!1.98!93.59!IKZF1;;chr6:135502408..135502459,+!p2@MYB!1.93!95.94!MYB;;chr6:135502501..135502546,+!p1@MYB!1.84!80.89!MYB;;chr19:33793430..33793447,-!p1@CEBPA!1.76!228.80!CEBPA;;chr7:137620650..137620677,-!p3@CREB3L2!1.74!53.54!CREB3L2;;chr7:115670804..115670825,-!p1@TFEC!1.72!51.58!TFEC;;chr12:54694758..54694805,-!p1@NFE2!1.71!60.77!NFE2;;chr21:34442439..34442455,+!p1@OLIG1!1.70!49.24!OLIG1;;chr19:13213662..13213686,-!p1@LYL1!1.69!69.56!LYL1;;chr14:75988771..75988826,+!p1@BATF!1.67!59.98!BATF;;chr16:85932760..85932775,+!p1@IRF8!1.61!39.66!IRF8;;chr1:92951607..92951661,-!p1@GFI1!1.58!37.12!GFI1;;chr7:27224842..27224872,-!p1@HOXA11!1.57!35.95!HOXA11;;chr12:54778471..54778528,-!p1@ZNF385A!1.56!35.37!ZNF385A;;chr12:54694807..54694832,-!p3@NFE2!1.53!33.22!NFE2;;chr7:137620684..137620711,-!p4@CREB3L2!1.44!26.57!CREB3L2;;chr7:27205136..27205164,-!p1@HOXA9!1.44!26.38!HOXA9;;chr7:27224795..27224840,-!p2@HOXA11!1.38!23.06!HOXA11;;chr21:34442540..34442560,+!p2@OLIG1!1.32!19.73!OLIG1;;chr10:31288398..31288455,-!p2@ZNF438!1.29!21.49!ZNF438;;chr2:68592394..68592405,+!p2@PLEK!1.29!18.56!PLEK;;chr7:27213893..27213954,-!p1@HOXA10!1.25!16.80!HOXA10;;chr11:47400062..47400077,-!p2@SPI1!1.22!15.63!SPI1;;chr2:60780607..60780624,-!p2@BCL11A!1.20!45.13!BCL11A;;chr2:239148671..239148686,-!p1@HES6!1.18!51.97!HES6;;chr2:172949484..172949522,+!p1@DLX1!1.18!14.26!DLX1;;chr19:13213954..13214021,-!p4@LYL1!1.17!13.68!LYL1;;chr12:54694653..54694672,-!p2@NFE2!1.17!13.68!NFE2;;chr13:72441315..72441454,-!p1@DACH1!1.14!25.60!DACH1;;chr2:100759037..100759058,-!p2@AFF3!1.14!12.90!AFF3;;chr7:27192185..27192209,-!p1@HOXA3!1.14!12.70!HOXA3;;chr7:128577972..128578047,+!p1@IRF5!1.13!19.93!IRF5;;chr2:200322654..200322707,-!p2@SATB2!1.13!18.17!SATB2;;chr6:135502472..135502489,+!p3@MYB!1.12!12.11!MYB;;chr2:145277882..145277967,-!p3@ZEB2!1.10!20.32!ZEB2;;chr12:54410664..54410684,+!p1@HOXC4,p1@HOXC5,p1@HOXC6!1.10!11.53!HOXC5;;chr2:145277640..145277771,-!p1@ZEB2!1.08!147.52!ZEB2;;chr10:31288370..31288393,-!p3@ZNF438!1.08!11.14!ZNF438;;chr11:19262461..19262476,-!p5@E2F8!1.08!11.14!E2F8;;chr1:92952473..92952489,-!p3@GFI1!1.08!11.14!GFI1;;chr7:27205106..27205134,-!p2@HOXA9!1.08!10.94!HOXA9;;chr7:50344251..50344288,+!p3@IKZF1!1.06!10.55!IKZF1;;chr2:200320768..200320800,-!p4@SATB2!1.06!10.36!SATB2;;chr3:18486354..18486377,-!p2@SATB1!1.05!12.90!SATB1;;chr2:60778035..60778060,-!p4@BCL11A!1.05!12.31!BCL11A;;chr11:47399996..47400014,-!p4@SPI1!1.02!9.57!SPI1;;chr6:135516877..135516900,+!p5@MYB!1.01!9.18!MYB;;chr11:128563948..128564003,+!p1@FLI1!1.00!111.76!FLI1;;chr7:50343634..50343717,+!p2@IKZF1!1.00!8.99!IKZF1;;chr1:92949505..92949543,-!p5@GFI1!1.00!8.99!GFI1;;chr20:42295745..42295765,+!p1@MYBL2!0.98!142.44!MYBL2;;chr19:13213704..13213726,-!p3@LYL1!0.98!11.33!LYL1;;chr11:19263160..19263176,-!p1@E2F8!0.95!9.38!E2F8;;chr11:47400045..47400060,-!p6@SPI1!0.95!7.82!SPI1;;chr2:100759010..100759035,-!p1@AFF3!0.95!7.82!AFF3;;chr20:42295713..42295738,+!p2@MYBL2!0.94!47.09!MYBL2;;chr2:60780753..60780800,-!p1@BCL11A!0.94!38.88!BCL11A;;chr7:27239703..27239715,-!p1@HOXA13!0.94!7.62!HOXA13;;chr14:75988831..75988847,+!p2@BATF!0.90!7.03!BATF;;chr13:79177703..79177729,-!p2@POU4F1!0.90!7.03!POU4F1;;chr13:41593425..41593480,-!p1@ELF1!0.88!44.55!ELF1;;chr21:36421535..36421610,-!p2@RUNX1!0.88!24.81!RUNX1;;chr1:23857698..23857733,-!p1@E2F2!0.88!12.50!E2F2;;chr2:102091566..102091581,-!p1@RFX8!0.87!6.45!RFX8;;chr11:47399947..47399961,-!p3@SPI1!0.87!6.45!SPI1;;chr9:77112244..77112262,+!p1@RORB!0.86!7.03!RORB;;chr11:19263192..19263222,-!p2@E2F8!0.85!7.62!E2F8;;chr12:48298785..48298828,-!p1@VDR!0.82!32.04!VDR;;chr17:41277372..41277418,-!p1@BRCA1!0.82!21.69!BRCA1;;chr8:145669791..145669834,-!p1@TONSL!0.82!17.19!TONSL;;chr2:200322711..200322722,-!p10@SATB2!0.82!5.67!SATB2;;chr16:54320675..54320715,-!p1@IRX3!0.79!11.92!IRX3;;chr16:88752889..88752921,-!p1@SNAI3!0.79!6.06!SNAI3;;chr6:144385698..144385742,-!p2@PLAGL1!0.78!6.25!PLAGL1;;chr6:135513595..135513617,+!p4@MYB!0.78!5.08!MYB;;chr11:19262421..19262455,-!p3@E2F8!0.78!5.08!E2F8;;chr13:79177674..79177701,-!p1@POU4F1!0.77!4.88!POU4F1;;chr6:135516909..135516925,+!p6@MYB!0.77!4.88!MYB;;chr1:25256756..25256774,-!p1@RUNX3!0.76!9.38!RUNX3;;chr6:20402102..20402152,+!p1@E2F3!0.74!20.32!E2F3;;chr11:47400032..47400043,-!p5@SPI1!0.74!4.49!SPI1;;chr12:54410639..54410659,+!p2@HOXC4,p2@HOXC5,p2@HOXC6!0.74!4.49!HOXC5;;chr2:113977697..113977733,-!p6@PAX8!0.74!4.49!PAX8;;chr17:41623692..41623715,-!p1@ETV4!0.73!20.52!ETV4;;chr2:66662281..66662308,+!p1@MEIS1!0.72!16.22!MEIS1;;chr19:47538560..47538591,+!p2@NPAS1!0.72!4.30!NPAS1;;chr20:50159198..50159299,-!p1@NFATC2!0.71!6.25!NFATC2;;chr10:31146746..31146755,-!p14@ZNF438!0.71!4.10!ZNF438;;chr12:54380404..54380433,+!p3@HOXC10!0.71!4.10!HOXC10;;chr12:54694738..54694749,-!p5@NFE2!0.71!4.10!NFE2;;chr5:1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|expression_enrichment_score=chr2:68592406..68592424,+!p1@PLEK!2.35!220.79!PLEK;;chr11:47400078..47400106,-!p1@SPI1!2.16!145.17!SPI1;;chr1:92949331..92949377,-!p2@GFI1!2.01!100.23!GFI1;;chr7:50344289..50344323,+!p1@IKZF1!1.98!93.59!IKZF1;;chr6:135502408..135502459,+!p2@MYB!1.93!95.94!MYB;;chr6:135502501..135502546,+!p1@MYB!1.84!80.89!MYB;;chr19:33793430..33793447,-!p1@CEBPA!1.76!228.80!CEBPA;;chr7:137620650..137620677,-!p3@CREB3L2!1.74!53.54!CREB3L2;;chr7:115670804..115670825,-!p1@TFEC!1.72!51.58!TFEC;;chr12:54694758..54694805,-!p1@NFE2!1.71!60.77!NFE2;;chr21:34442439..34442455,+!p1@OLIG1!1.70!49.24!OLIG1;;chr19:13213662..13213686,-!p1@LYL1!1.69!69.56!LYL1;;chr14:75988771..75988826,+!p1@BATF!1.67!59.98!BATF;;chr16:85932760..85932775,+!p1@IRF8!1.61!39.66!IRF8;;chr1:92951607..92951661,-!p1@GFI1!1.58!37.12!GFI1;;chr7:27224842..27224872,-!p1@HOXA11!1.57!35.95!HOXA11;;chr12:54778471..54778528,-!p1@ZNF385A!1.56!35.37!ZNF385A;;chr12:54694807..54694832,-!p3@NFE2!1.53!33.22!NFE2;;chr7:137620684..137620711,-!p4@CREB3L2!1.44!26.57!CREB3L2;;chr7:27205136..27205164,-!p1@HOXA9!1.44!26.38!HOXA9;;chr7:27224795..27224840,-!p2@HOXA11!1.38!23.06!HOXA11;;chr21:34442540..34442560,+!p2@OLIG1!1.32!19.73!OLIG1;;chr10:31288398..31288455,-!p2@ZNF438!1.29!21.49!ZNF438;;chr2:68592394..68592405,+!p2@PLEK!1.29!18.56!PLEK;;chr7:27213893..27213954,-!p1@HOXA10!1.25!16.80!HOXA10;;chr11:47400062..47400077,-!p2@SPI1!1.22!15.63!SPI1;;chr2:60780607..60780624,-!p2@BCL11A!1.20!45.13!BCL11A;;chr2:239148671..239148686,-!p1@HES6!1.18!51.97!HES6;;chr2:172949484..172949522,+!p1@DLX1!1.18!14.26!DLX1;;chr19:13213954..13214021,-!p4@LYL1!1.17!13.68!LYL1;;chr12:54694653..54694672,-!p2@NFE2!1.17!13.68!NFE2;;chr13:72441315..72441454,-!p1@DACH1!1.14!25.60!DACH1;;chr2:100759037..100759058,-!p2@AFF3!1.14!12.90!AFF3;;chr7:27192185..27192209,-!p1@HOXA3!1.14!12.70!HOXA3;;chr7:128577972..128578047,+!p1@IRF5!1.13!19.93!IRF5;;chr2:200322654..200322707,-!p2@SATB2!1.13!18.17!SATB2;;chr6:135502472..135502489,+!p3@MYB!1.12!12.11!MYB;;chr2:145277882..145277967,-!p3@ZEB2!1.10!20.32!ZEB2;;chr12:54410664..54410684,+!p1@HOXC4,p1@HOXC5,p1@HOXC6!1.10!11.53!HOXC5;;chr2:145277640..145277771,-!p1@ZEB2!1.08!147.52!ZEB2;;chr10:31288370..31288393,-!p3@ZNF438!1.08!11.14!ZNF438;;chr11:19262461..19262476,-!p5@E2F8!1.08!11.14!E2F8;;chr1:92952473..92952489,-!p3@GFI1!1.08!11.14!GFI1;;chr7:27205106..27205134,-!p2@HOXA9!1.08!10.94!HOXA9;;chr7:50344251..50344288,+!p3@IKZF1!1.06!10.55!IKZF1;;chr2:200320768..200320800,-!p4@SATB2!1.06!10.36!SATB2;;chr3:18486354..18486377,-!p2@SATB1!1.05!12.90!SATB1;;chr2:60778035..60778060,-!p4@BCL11A!1.05!12.31!BCL11A;;chr11:47399996..47400014,-!p4@SPI1!1.02!9.57!SPI1;;chr6:135516877..135516900,+!p5@MYB!1.01!9.18!MYB;;chr11:128563948..128564003,+!p1@FLI1!1.00!111.76!FLI1;;chr7:50343634..50343717,+!p2@IKZF1!1.00!8.99!IKZF1;;chr1:92949505..92949543,-!p5@GFI1!1.00!8.99!GFI1;;chr20:42295745..42295765,+!p1@MYBL2!0.98!142.44!MYBL2;;chr19:13213704..13213726,-!p3@LYL1!0.98!11.33!LYL1;;chr11:19263160..19263176,-!p1@E2F8!0.95!9.38!E2F8;;chr11:47400045..47400060,-!p6@SPI1!0.95!7.82!SPI1;;chr2:100759010..100759035,-!p1@AFF3!0.95!7.82!AFF3;;chr20:42295713..42295738,+!p2@MYBL2!0.94!47.09!MYBL2;;chr2:60780753..60780800,-!p1@BCL11A!0.94!38.88!BCL11A;;chr7:27239703..27239715,-!p1@HOXA13!0.94!7.62!HOXA13;;chr14:75988831..75988847,+!p2@BATF!0.90!7.03!BATF;;chr13:79177703..79177729,-!p2@POU4F1!0.90!7.03!POU4F1;;chr13:41593425..41593480,-!p1@ELF1!0.88!44.55!ELF1;;chr21:36421535..36421610,-!p2@RUNX1!0.88!24.81!RUNX1;;chr1:23857698..23857733,-!p1@E2F2!0.88!12.50!E2F2;;chr2:102091566..102091581,-!p1@RFX8!0.87!6.45!RFX8;;chr11:47399947..47399961,-!p3@SPI1!0.87!6.45!SPI1;;chr9:77112244..77112262,+!p1@RORB!0.86!7.03!RORB;;chr11:19263192..19263222,-!p2@E2F8!0.85!7.62!E2F8;;chr12:48298785..48298828,-!p1@VDR!0.82!32.04!VDR;;chr17:41277372..41277418,-!p1@BRCA1!0.82!21.69!BRCA1;;chr8:145669791..145669834,-!p1@TONSL!0.82!17.19!TONSL;;chr2:200322711..200322722,-!p10@SATB2!0.82!5.67!SATB2;;chr16:54320675..54320715,-!p1@IRX3!0.79!11.92!IRX3;;chr16:88752889..88752921,-!p1@SNAI3!0.79!6.06!SNAI3;;chr6:144385698..144385742,-!p2@PLAGL1!0.78!6.25!PLAGL1;;chr6:135513595..135513617,+!p4@MYB!0.78!5.08!MYB;;chr11:19262421..19262455,-!p3@E2F8!0.78!5.08!E2F8;;chr13:79177674..79177701,-!p1@POU4F1!0.77!4.88!POU4F1;;chr6:135516909..135516925,+!p6@MYB!0.77!4.88!MYB;;chr1:25256756..25256774,-!p1@RUNX3!0.76!9.38!RUNX3;;chr6:20402102..20402152,+!p1@E2F3!0.74!20.32!E2F3;;chr11:47400032..47400043,-!p5@SPI1!0.74!4.49!SPI1;;chr12:54410639..54410659,+!p2@HOXC4,p2@HOXC5,p2@HOXC6!0.74!4.49!HOXC5;;chr2:113977697..113977733,-!p6@PAX8!0.74!4.49!PAX8;;chr17:41623692..41623715,-!p1@ETV4!0.73!20.52!ETV4;;chr2:66662281..66662308,+!p1@MEIS1!0.72!16.22!MEIS1;;chr19:47538560..47538591,+!p2@NPAS1!0.72!4.30!NPAS1;;chr20:50159198..50159299,-!p1@NFATC2!0.71!6.25!NFATC2;;chr10:31146746..31146755,-!p14@ZNF438!0.71!4.10!ZNF438;;chr12:54380404..54380433,+!p3@HOXC10!0.71!4.10!HOXC10;;chr12:54694738..54694749,-!p5@NFE2!0.71!4.10!NFE2;;chr5:1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Line 45: Line 45:
|is_obsolete=
|is_obsolete=
|library_id=CNhs13058
|library_id=CNhs13058
|library_id_phase_based=1:CNhs13058
|library_id_phase_based=2:CNhs13058
|name=acute myeloid leukemia (FAB M5) cell line:U-937 DE-4
|name=acute myeloid leukemia (FAB M5) cell line:U-937 DE-4
|namespace=FANTOM5
|namespace=FANTOM5
|part_of=
|part_of=
|profile_cagescan=,,,
|profile_cagescan=,,,
|profile_hcage=CNhs13058,LSID1000,release012,COMPLETED
|profile_hcage="CNhs13058,LSID1000,release012,COMPLETED"
|profile_rnaseq=,,,
|profile_rnaseq=
|profile_srnaseq=,,,
|profile_srnaseq=",,,"
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Revision as of 17:28, 27 November 2014


Name:acute myeloid leukemia (FAB M5) cell line:U-937 DE-4
Species:Human (Homo sapiens)
Library ID:CNhs13058
Sample type:cell lines
Genomic View: UCSC
CAGEd-oPOSSUM:link
Additional information
Sample information
strainNA
tissueblood
dev stageNA
sexmale
age37
cell typemonoblast
cell lineU-937 DE-4
companyRIKEN Bioresource centre
collaborationYukio Nakamura (RIKEN BRC)
External link for information[{{{sample_info_link}}} {{{sample_info_link}}}]
RNA information
lot numberNA
catalog numberNA
sample typetotal RNA
extraction protocol (Details)OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0

CAGE Accession numbers
MethodSample accession id
CAGE  SAMD00004814
Library accession numbers

Library idMethodExp. accession idRun accession id
CNhs13058 CAGE DRX007816 DRR008688
Accession ID Hg19

Library idBAMCTSS
CNhs13058 DRZ000113 DRZ001498
Download raw sequence, BAM & CTSS
Hg19
BAMCTSS
[{{{hg19bam}}} download][{{{hg19ctss}}} donwload]
Hg38
BAMCTSS
[{{{hg38bam}}} download][{{{hg38ctss}}} donwload]


Relative expression to median (log10)


Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.



Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>dataNo results for this sample

Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data



TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample


JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: "CNhs13058This sample isn't target for the analysis

FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: "CNhs13058This sample isn't target for the analysis

de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br> library id: "CNhs13058


FANTOM5 (FF) ontology


Direct parent terms


Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data

CL: Cell type
0000000 (cell), 0000000 (cell)
0000003 (native cell)
0000988 (hematopoietic cell)
0000548 (animal cell)
0000763 (myeloid cell)
0002371 (somatic cell)
0000255 (eukaryotic cell)

DOID: Disease
4 (disease)
0050686 (organ system cancer)
162 (cancer)
2531 (hematologic cancer)
14566 (disease of cellular proliferation)
0060083 (immune system cancer)
1240 (leukemia)
8692 (myeloid leukemia)

FF: FANTOM5
0000102 (sample by type)
0000003 (cell line sample)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0100737 (leukemia cell line sample)
0101035 (hematopoietic cell line sample)
0101883 (acute myeloid leukemia cell line sample)
0100740 (myeloid leukemia cell line sample)

Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000049 (common myeloid progenitor)
CL:0000134 (mesenchymal cell)