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Coexpression cluster:C1593

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Full id: C1593_anaplastic_NK_blood_Natural_CD8_Whole_adult



Phase1 CAGE Peaks

Hg19::chr10:72357594..72357605,-p4@PRF1
Hg19::chr10:72362487..72362507,-p2@PRF1
Hg19::chr10:72362665..72362683,-p5@PRF1
Hg19::chr19:51875523..51875549,-p@chr19:51875523..51875549
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Hg19::chr19:55417469..55417480,+p2@NCR1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
2.28656823893637e-050.01447397695246722137Natural killer cell mediated cytotoxicity (KEGG):04650



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0001906cell killing2.68685548807027e-05
GO:0006968cellular defense response0.000252485390717191
GO:0051801cytolysis of cells in other organism during symbiotic interaction0.000958744547581376
GO:0001907killing by symbiont of host cells0.000958744547581376
GO:0052331hemolysis by organism of red blood cells in other organism during symbiotic interaction0.000958744547581376
GO:0051817modification of morphology or physiology of other organism during symbiotic interaction0.000958744547581376
GO:0051715cytolysis of cells of another organism0.000958744547581376
GO:0052043modification by symbiont of host cellular component0.000958744547581376
GO:0006927transformed cell apoptosis0.000958744547581376
GO:0031640killing of cells of another organism0.000958744547581376
GO:0001897cytolysis by symbiont of host cells0.000958744547581376
GO:0052185modification of structure of other organism during symbiotic interaction0.000958744547581376
GO:0051818disruption of cells of other organism during symbiotic interaction0.000958744547581376
GO:0052332modification by organism of cell membrane in other organism during symbiotic interaction0.000958744547581376
GO:0051883killing of cells in other organism during symbiotic interaction0.000958744547581376
GO:0019836hemolysis by symbiont of host red blood cells0.000958744547581376
GO:0044003modification by symbiont of host morphology or physiology0.000958744547581376
GO:0052188modification of cellular component in other organism during symbiotic interaction0.000958744547581376
GO:0052111modification by symbiont of host structure0.000958744547581376
GO:0052025modification by symbiont of host cell membrane0.000958744547581376
GO:0044004disruption by symbiont of host cells0.000958744547581376
GO:0006926virus-infected cell apoptosis0.00122020237302143
GO:0006952defense response0.00146227471504837
GO:0042269regulation of natural killer cell mediated cytotoxicity0.00195732153961825
GO:0016514SWI/SNF complex0.00206483628486486
GO:0045471response to ethanol0.00206483628486486
GO:0001910regulation of leukocyte mediated cytotoxicity0.00230670741862533
GO:0031341regulation of cell killing0.00230670741862533
GO:0006915apoptosis0.00230670741862533
GO:0012501programmed cell death0.00230670741862533
GO:0042267natural killer cell mediated cytotoxicity0.00230670741862533
GO:0002228natural killer cell mediated immunity0.00230670741862533
GO:0016265death0.00239270756740181
GO:0008219cell death0.00239270756740181
GO:0009405pathogenesis0.00249236892117645
GO:0001909leukocyte mediated cytotoxicity0.00260949314776118
GO:0019835cytolysis0.00290159034559855
GO:0030101natural killer cell activation0.00317829321061253
GO:0051701interaction with host0.00378475306873572
GO:0048468cell development0.00380635062002154
GO:0007623circadian rhythm0.00474513809620455
GO:0044403symbiosis, encompassing mutualism through parasitism0.00499225835979043
GO:0044419interspecies interaction between organisms0.00499225835979043
GO:0016585chromatin remodeling complex0.00625013144668185
GO:0048869cellular developmental process0.00703128521102429
GO:0030154cell differentiation0.00703128521102429
GO:0010033response to organic substance0.00884539981063303
GO:0002449lymphocyte mediated immunity0.0100565938693465
GO:0002443leukocyte mediated immunity0.0106713602344203
GO:0002252immune effector process0.0147414128790072
GO:0045087innate immune response0.0149770229113583
GO:0046649lymphocyte activation0.0199598181369645
GO:0032502developmental process0.0208728226941865
GO:0005057receptor signaling protein activity0.0219067445981678
GO:0045321leukocyte activation0.0219067445981678
GO:0001775cell activation0.0245701659673497
GO:0006917induction of apoptosis0.0245701659673497
GO:0012502induction of programmed cell death0.0245701659673497
GO:0043065positive regulation of apoptosis0.0287498970203366
GO:0043068positive regulation of programmed cell death0.0287498970203366
GO:0051704multi-organism process0.0364586630602866
GO:0016023cytoplasmic membrane-bound vesicle0.0373049438326
GO:0031988membrane-bound vesicle0.0373049438326
GO:0031410cytoplasmic vesicle0.044289821495002
GO:0031982vesicle0.0443221006614301
GO:0044451nucleoplasm part0.0456578825829426



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
T cell7.66e-2925
pro-T cell7.66e-2925
mature alpha-beta T cell3.10e-2618
alpha-beta T cell3.10e-2618
immature T cell3.10e-2618
mature T cell3.10e-2618
immature alpha-beta T cell3.10e-2618
CD8-positive, alpha-beta T cell7.12e-2511
lymphoid lineage restricted progenitor cell1.12e-1552
lymphocyte2.93e-1553
common lymphoid progenitor2.93e-1553
hematopoietic cell4.87e-15177
hematopoietic stem cell1.41e-14168
angioblastic mesenchymal cell1.41e-14168
nucleate cell1.81e-1455
leukocyte7.53e-13136
hematopoietic oligopotent progenitor cell4.39e-12161
hematopoietic multipotent progenitor cell4.39e-12161
nongranular leukocyte7.19e-12115
circulating cell2.46e-096
hematopoietic lineage restricted progenitor cell3.71e-09120
natural killer cell3.09e-083
pro-NK cell3.09e-083
single nucleate cell2.05e-073
mononuclear cell2.05e-073
basophil2.14e-073
Uber Anatomy
Ontology termp-valuen
blood4.20e-2715
haemolymphatic fluid4.20e-2715
organism substance4.20e-2715
hematopoietic system2.85e-1098
blood island2.85e-1098
hemolymphoid system2.88e-10108
hemopoietic organ4.11e-107
immune organ4.11e-107
thymus1.36e-084
hemolymphoid system gland1.36e-084
thymic region1.36e-084
pharyngeal gland1.36e-084
thymus primordium1.36e-084
adult organism4.52e-07114


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.481059
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.660087
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.11.08193
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.11.74614
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.362215
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.11.15584
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.11.58771
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.973423
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.6031
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.21.41923
MA0035.20.691506
MA0039.20.311551
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.858845
MA0047.20.767096
MA0112.20.839774
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.11.20729
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.21472
MA0163.10.168633
MA0164.11.89806
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.230892
MA0102.21.66336
MA0258.10.914277
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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