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Coexpression cluster:C1754

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Full id: C1754_immature_CD14_Dendritic_CD34_Basophils_Mast_migratory



Phase1 CAGE Peaks

Hg19::chr15:86123791..86123808,+p22@AKAP13
Hg19::chr15:86124854..86124875,+p30@AKAP13
Hg19::chr19:3136115..3136165,+p2@GNA15
Hg19::chr3:119013434..119013460,+p3@ARHGAP31
Hg19::chr3:119013476..119013540,+p2@ARHGAP31


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
3.28059829023111e-050.0133922329919482295G Protein Signaling Pathways (Wikipathways):WP35
5.33094045966131e-050.01339223299194822121Signaling by Rho GTPases (Reactome):REACT_11044
6.34702985400389e-050.01339223299194822132{RAC1,133} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007207muscarinic acetylcholine receptor, phospholipase C activating pathway0.0192505813106471
GO:0004691cAMP-dependent protein kinase activity0.0256625304030679
GO:0004690cyclic nucleotide-dependent protein kinase activity0.0256625304030679
GO:0007202phospholipase C activation0.0256625304030679
GO:0006471protein amino acid ADP-ribosylation0.0333563781795267
GO:0005834heterotrimeric G-protein complex0.0395508365680418
GO:0019897extrinsic to plasma membrane0.0405964492107154
GO:0007242intracellular signaling cascade0.0405964492107154
GO:0019992diacylglycerol binding0.0405964492107154
GO:0051480cytosolic calcium ion homeostasis0.0405964492107154
GO:0007204elevation of cytosolic calcium ion concentration0.0405964492107154
GO:0051345positive regulation of hydrolase activity0.0405964492107154
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)0.0433828646488185
GO:0019898extrinsic to membrane0.043486306495677
GO:0055074calcium ion homeostasis0.043486306495677
GO:0006874cellular calcium ion homeostasis0.043486306495677
GO:0006875cellular metal ion homeostasis0.043486306495677
GO:0055065metal ion homeostasis0.043486306495677
GO:0048015phosphoinositide-mediated signaling0.043486306495677
GO:0005089Rho guanyl-nucleotide exchange factor activity0.0448398258562391
GO:0035023regulation of Rho protein signal transduction0.0448398258562391
GO:0005088Ras guanyl-nucleotide exchange factor activity0.0448398258562391
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.0448398258562391
GO:0055066di-, tri-valent inorganic cation homeostasis0.0448398258562391
GO:0007266Rho protein signal transduction0.0448398258562391
GO:0030003cellular cation homeostasis0.0448398258562391
GO:0055080cation homeostasis0.0448398258562391
GO:0060089molecular transducer activity0.0448398258562391
GO:0004871signal transducer activity0.0448398258562391
GO:0055082cellular chemical homeostasis0.0488889669249315
GO:0006873cellular ion homeostasis0.0488889669249315



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
granulocyte monocyte progenitor cell1.20e-5567
leukocyte2.11e-53136
myeloid leukocyte1.06e-5172
macrophage dendritic cell progenitor6.22e-5061
myeloid lineage restricted progenitor cell6.57e-5066
defensive cell7.29e-4948
phagocyte7.29e-4948
monopoietic cell1.43e-4759
monocyte1.43e-4759
monoblast1.43e-4759
promonocyte1.43e-4759
hematopoietic lineage restricted progenitor cell6.13e-44120
classical monocyte9.43e-4442
CD14-positive, CD16-negative classical monocyte9.43e-4442
nongranular leukocyte5.82e-42115
hematopoietic stem cell2.05e-40168
angioblastic mesenchymal cell2.05e-40168
myeloid cell2.41e-37108
common myeloid progenitor2.41e-37108
hematopoietic oligopotent progenitor cell2.76e-37161
hematopoietic multipotent progenitor cell2.76e-37161
hematopoietic cell1.80e-36177
stuff accumulating cell5.02e-2387
dendritic cell3.27e-1210
conventional dendritic cell2.86e-108
intermediate monocyte3.46e-099
CD14-positive, CD16-positive monocyte3.46e-099
mesenchymal cell9.33e-08354
immature conventional dendritic cell1.13e-075
common dendritic progenitor1.13e-075
connective tissue cell4.41e-07361
Uber Anatomy
Ontology termp-valuen
bone marrow8.27e-4876
hematopoietic system1.84e-4598
blood island1.84e-4598
immune system4.20e-4393
bone element2.21e-4282
hemolymphoid system4.15e-41108
skeletal element1.38e-3790
skeletal system2.42e-32100
lateral plate mesoderm1.01e-19203
adult organism1.97e-18114
musculoskeletal system4.05e-13167
mesoderm4.94e-08315
mesoderm-derived structure4.94e-08315
presumptive mesoderm4.94e-08315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.481059
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.161847
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.12.49194
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.10.554727
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.11.98392
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.215829
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.11.16366
MA0103.10.442769
MA0105.11.00065
MA0106.10.779931
MA0107.10.985964
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.11.8711
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.759606
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.11.87149
MA0144.10.356507
MA0145.10.143698
MA0146.10.333008
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.21.35805
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.10.130813
MA0156.11.20729
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.21472
MA0163.11.05321
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.636989
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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