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Coexpression cluster:C1915

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Full id: C1915_Mast_CD14_testicular_Eosinophils_Neutrophils_Basophils_Peripheral



Phase1 CAGE Peaks

Hg19::chr3:10291055..10291076,-p2@BC009749
Hg19::chr6:15246200..15246214,+p2@JARID2
Hg19::chr6:15246217..15246228,+p3@JARID2
Hg19::chr6:15246261..15246312,+p1@JARID2
Hg19::chr6:15246741..15246765,+p9@JARID2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell5.14e-48168
angioblastic mesenchymal cell5.14e-48168
myeloid cell1.46e-47108
common myeloid progenitor1.46e-47108
hematopoietic oligopotent progenitor cell2.26e-44161
hematopoietic multipotent progenitor cell2.26e-44161
hematopoietic cell3.85e-41177
myeloid leukocyte6.09e-3772
leukocyte4.31e-36136
granulocyte monocyte progenitor cell2.69e-3367
myeloid lineage restricted progenitor cell2.14e-3266
hematopoietic lineage restricted progenitor cell4.42e-30120
macrophage dendritic cell progenitor4.90e-3061
monopoietic cell8.44e-2959
monocyte8.44e-2959
monoblast8.44e-2959
promonocyte8.44e-2959
defensive cell1.20e-2648
phagocyte1.20e-2648
nongranular leukocyte1.50e-26115
classical monocyte1.33e-2542
CD14-positive, CD16-negative classical monocyte1.33e-2542
stuff accumulating cell6.08e-1087
granulocyte9.92e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system7.13e-3098
blood island7.13e-3098
bone marrow7.74e-2776
bone element2.01e-2682
hemolymphoid system3.86e-26108
immune system2.58e-2393
skeletal element7.35e-2390
skeletal system4.20e-19100
Disease
Ontology termp-valuen
myeloid leukemia1.80e-0931
leukemia1.72e-0839


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.24383
MA0004.10.626788
MA0006.10.452993
MA0007.11.47524
MA0009.11.11255
MA0014.10.369468
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.11.55172
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.14.57459
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0469445
MA0074.11.73427
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.12.26263
MA0106.10.779931
MA0107.10.985964
MA0108.23.56647
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.11.25946
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.868598
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.15493
MA0138.23.2415
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.425004
MA0065.20.449243
MA0150.10.550239
MA0151.10
MA0152.11.66846
MA0153.11.21379
MA0154.10.172764
MA0155.10.813062
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.13.53221
MA0163.10.0439995
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.636989
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187935.34388010794140.01187615563868110.0432428204423603
EGR1#195843.990543275848110.0067800983001440.0287731282555359
ETS1#211335.83725655332140.009253279045631430.0349778569708169
FAM48A#555783693.101256.35816014900193e-095.0267970310493e-07
GTF2B#2959319.16629796059450.0002924229654472410.00310274937400634
IRF3#3661328.18917132689379.33088977565955e-050.00135649888262821
MXI1#460135.976942977255580.008653004889366880.0329556989876956
NFYA#4800311.05534841989830.001470892907644430.00941348026113587
STAT1#6772312.42395249831950.0010460253449530.00739446602149356
TFAP2A#702039.911180623826970.002021546977511280.0117463193938077
TFAP2C#702236.485537165916130.006858951517940.0290640661168554
YY1#752843.928936599883080.007193866269917620.0298522011826099
ZNF143#770238.100525931336740.003624870512090980.0183357316516816



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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