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Coexpression cluster:C1996

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Full id: C1996_Natural_CD8_NK_CD4_Peripheral_blood_Whole



Phase1 CAGE Peaks

  Short description
Hg19::chr7:38357069..38357141,- p1@TARP
Hg19::chr7:38357145..38357165,- p6@TARP
Hg19::chr7:38357177..38357188,- p8@TARP
Hg19::chr7:38357258..38357299,- p2@TARP
Hg19::chr7:38375259..38375289,- p2@uc010kxk.1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0042605peptide antigen binding0.0050777110561639
GO:0042287MHC protein binding0.0050777110561639
GO:0003823antigen binding0.0229600847756976
GO:0042277peptide binding0.0229600847756976



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
CD8-positive, alpha-beta T cell1.31e-2011
mature alpha-beta T cell2.21e-1618
alpha-beta T cell2.21e-1618
immature T cell2.21e-1618
mature T cell2.21e-1618
immature alpha-beta T cell2.21e-1618
hematopoietic stem cell2.05e-14168
angioblastic mesenchymal cell2.05e-14168
T cell3.34e-1425
pro-T cell3.34e-1425
hematopoietic cell5.76e-13177
leukocyte1.36e-12136
nongranular leukocyte3.57e-12115
hematopoietic oligopotent progenitor cell3.89e-12161
hematopoietic multipotent progenitor cell3.89e-12161
hematopoietic lineage restricted progenitor cell2.39e-09120
lymphoid lineage restricted progenitor cell1.46e-0852
lymphocyte2.65e-0853
common lymphoid progenitor2.65e-0853
nucleate cell8.17e-0855
natural killer cell4.34e-073
pro-NK cell4.34e-073
single nucleate cell6.60e-073
mononuclear cell6.60e-073
basophil9.44e-073
Uber Anatomy
Ontology termp-valuen
adult organism1.12e-17114
blood2.08e-1715
haemolymphatic fluid2.08e-1715
organism substance2.08e-1715
hematopoietic system9.03e-1598
blood island9.03e-1598
hemolymphoid system2.26e-14108
hemopoietic organ1.03e-097
immune organ1.03e-097
thymus2.51e-084
hemolymphoid system gland2.51e-084
thymic region2.51e-084
pharyngeal gland2.51e-084
thymus primordium2.51e-084


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.11.7452
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.11.01397
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.791444
MA0063.10
MA0066.11.74614
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.11.05325
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.11.95181
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.15.03975
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.11.12656
MA0105.10.520776
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.759606
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.442008
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.25.14792
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.26.8385
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.11.57192
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.11.00463
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.000396307
MA0102.21.66336
MA0258.13.40476
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCFL#140690519.74647435897443.32745051287657e-071.66037077933262e-05
MAX#414945.16204440720570.002526309009485180.0140052649631946



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.