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Coexpression cluster:C2160

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Full id: C2160_Neutrophils_Eosinophils_CD14_Dendritic_Peripheral_Natural_CD19



Phase1 CAGE Peaks

  Short description
Hg19::chr11:70117214..70117224,- p@chr11:70117214..70117224
-
Hg19::chr11:73087410..73087452,+ p1@RELT
Hg19::chr17:63014205..63014211,- p@chr17:63014205..63014211
-
Hg19::chr1:6640110..6640130,+ p2@ZBTB48


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
hematopoietic stem cell9.30e-65168
angioblastic mesenchymal cell9.30e-65168
hematopoietic cell6.62e-61177
hematopoietic oligopotent progenitor cell1.77e-60161
hematopoietic multipotent progenitor cell1.77e-60161
leukocyte7.85e-55136
hematopoietic lineage restricted progenitor cell2.27e-44120
nongranular leukocyte3.39e-44115
myeloid cell3.41e-43108
common myeloid progenitor3.41e-43108
myeloid leukocyte5.03e-3372
granulocyte monocyte progenitor cell1.16e-2967
macrophage dendritic cell progenitor1.07e-2861
myeloid lineage restricted progenitor cell2.97e-2866
monopoietic cell1.84e-2759
monocyte1.84e-2759
monoblast1.84e-2759
promonocyte1.84e-2759
defensive cell1.71e-2648
phagocyte1.71e-2648
classical monocyte4.34e-2642
CD14-positive, CD16-negative classical monocyte4.34e-2642
nucleate cell3.87e-1555
lymphocyte9.35e-1553
common lymphoid progenitor9.35e-1553
lymphoid lineage restricted progenitor cell2.03e-1452
lymphocyte of B lineage1.82e-0824
pro-B cell1.82e-0824
motile cell1.31e-07386
mesenchymal cell1.71e-07354
intermediate monocyte3.31e-079
CD14-positive, CD16-positive monocyte3.31e-079
B cell7.58e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.30e-3298
blood island2.30e-3298
hemolymphoid system1.86e-27108
bone marrow1.39e-2476
bone element1.77e-2282
immune system4.18e-2193
skeletal element1.63e-1690
skeletal system4.86e-12100
blood1.31e-0715
haemolymphatic fluid1.31e-0715
organism substance1.31e-0715
Disease
Ontology termp-valuen
hematologic cancer3.40e-1151
immune system cancer3.40e-1151
leukemia1.90e-0939
myeloid leukemia1.13e-0731
organ system cancer7.37e-07137


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.896009
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.11.22348
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.481
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.21.13403
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.22.02192
MA0099.20.7872
MA0079.21.38179
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672210.09211532161190.0137713969900260.0484641618169399



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.