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Coexpression cluster:C667

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Full id: C667_CD14_tenocyte_Synoviocyte_Smooth_dura_Preadipocyte_Macrophage



Phase1 CAGE Peaks

Hg19::chr2:38295461..38295480,-p@chr2:38295461..38295480
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Hg19::chr2:38296784..38296796,-p@chr2:38296784..38296796
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Hg19::chr2:38297270..38297290,-p@chr2:38297270..38297290
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Hg19::chr2:38297628..38297658,-p@chr2:38297628..38297658
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Hg19::chr2:38297677..38297731,-p@chr2:38297677..38297731
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Hg19::chr2:38302488..38302516,-p5@CYP1B1
Hg19::chr2:38303286..38303301,-p1@CYP1B1
Hg19::chr9:90342509..90342530,+p3@CTSL1
Hg19::chr9:90342545..90342564,+p2@CTSL1
Hg19::chr9:90344555..90344567,+p@chr9:90344555..90344567
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Hg19::chr9:90344568..90344585,+p@chr9:90344568..90344585
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Hg19::chr9:90345291..90345317,+p@chr9:90345291..90345317
+
Hg19::chr9:90345922..90345945,+p@chr9:90345922..90345945
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
5.75225560838478e-050.03641177800107572217IL-4 up reg. targets (Netpath):NetPath_16



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004217cathepsin L activity0.00812421811231538
GO:0008210estrogen metabolic process0.0243690670105399
GO:0050381unspecific monooxygenase activity0.0351925090884915
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.0419380578740978
GO:0019825oxygen binding0.0419380578740978
GO:0010033response to organic substance0.0419380578740978
GO:0042445hormone metabolic process0.0496449157332622
GO:0004197cysteine-type endopeptidase activity0.0496449157332622
GO:0005792microsome0.0496449157332622
GO:0042598vesicular fraction0.0496449157332622
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0496449157332622
GO:0006725aromatic compound metabolic process0.0496449157332622
GO:0005764lysosome0.0496449157332622
GO:0000323lytic vacuole0.0496449157332622
GO:0007601visual perception0.0496449157332622
GO:0050953sensory perception of light stimulus0.0496449157332622
GO:0008202steroid metabolic process0.0496449157332622
GO:0005773vacuole0.0496449157332622
GO:0004497monooxygenase activity0.0496449157332622



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
skeletal system1.14e-17100
skeletal element4.95e-1790
bone marrow1.83e-1676
musculoskeletal system2.64e-16167
bone element2.93e-1682
connective tissue1.53e-15371
mesoderm6.86e-13315
mesoderm-derived structure6.86e-13315
presumptive mesoderm6.86e-13315
immune system9.38e-1393
hematopoietic system1.58e-1098
blood island1.58e-1098
hemolymphoid system1.01e-08108
organ9.97e-07503


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00135586
MA0004.10.806989
MA0006.10.169524
MA0007.11.40863
MA0009.10.724811
MA0014.10.00634684
MA0017.10.199401
MA0019.10.428118
MA0024.11.51255
MA0025.10.854131
MA0027.12.32165
MA0028.10.181601
MA0029.10.642879
MA0030.10.63197
MA0031.10.570886
MA0038.10.387473
MA0040.10.648455
MA0041.10.313738
MA0042.10.286538
MA0043.10.725115
MA0046.10.714324
MA0048.10.0323146
MA0050.10.287284
MA0051.10.383704
MA0052.10.652145
MA0055.10.0277818
MA0056.10
MA0057.10.0301256
MA0058.10.625569
MA0059.10.623149
MA0060.10.0892161
MA0061.10.255087
MA0063.10
MA0066.10.387854
MA0067.11.03434
MA0068.10.0529803
MA0069.10.710614
MA0070.10.69985
MA0071.10.35315
MA0072.10.695528
MA0073.10.000252324
MA0074.10.383033
MA0076.10.231962
MA0077.10.688123
MA0078.10.473657
MA0081.10.623454
MA0083.10.732051
MA0084.11.21913
MA0087.10.693179
MA0088.10.0644248
MA0089.10
MA0090.10.243681
MA0091.10.30011
MA0092.10.268302
MA0093.10.511707
MA0095.10
MA0098.10
MA0100.11.82424
MA0101.10.17426
MA0103.10.162663
MA0105.10.0255214
MA0106.10.424592
MA0107.10.385539
MA0108.20.568002
MA0109.10
MA0111.10.254772
MA0113.11.1195
MA0114.10.376635
MA0115.10.959312
MA0116.10.123927
MA0117.10.76111
MA0119.10.205526
MA0122.10.786181
MA0124.10.918678
MA0125.10.83671
MA0130.10
MA0131.10.490408
MA0132.10
MA0133.10
MA0135.10.754112
MA0136.11.02008
MA0139.10.0663461
MA0140.10.350813
MA0141.10.216821
MA0142.11.33676
MA0143.10.439666
MA0144.10.35188
MA0145.10.0753792
MA0146.10.0045745
MA0147.10.397782
MA0148.10.319209
MA0149.10.342334
MA0062.20.0702147
MA0035.20.924091
MA0039.20.00196561
MA0138.20.474787
MA0002.20.280231
MA0137.20.186529
MA0104.20.298328
MA0047.20.413608
MA0112.20.355033
MA0065.20.200291
MA0150.10.238884
MA0151.10
MA0152.10.938262
MA0153.10.820317
MA0154.10.105196
MA0155.10.167839
MA0156.10.551743
MA0157.10.515488
MA0158.10
MA0159.10.398903
MA0160.10.332385
MA0161.10
MA0162.10.00205586
MA0163.10.00707238
MA0164.11.99707
MA0080.20.511865
MA0018.20.425847
MA0099.20.356906
MA0079.24.63921e-06
MA0102.21.25596
MA0258.11.13482
MA0259.10.412624
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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