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Coexpression cluster:C575

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Full id: C575_embryonic_CD14_CD34_immature_chorionic_Mast_testis



Phase1 CAGE Peaks

Hg19::chr10:106008834..106008840,+p@chr10:106008834..106008840
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Hg19::chr10:132517789..132517796,+p@chr10:132517789..132517796
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Hg19::chr10:81088710..81088726,+p@chr10:81088710..81088726
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Hg19::chr12:111842525..111842550,+p@chr12:111842525..111842550
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Hg19::chr12:90354099..90354111,-p@chr12:90354099..90354111
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Hg19::chr17:76858299..76858316,+p@chr17:76858299..76858316
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Hg19::chr19:55919546..55919557,-p5@UBE2S
Hg19::chr22:30602042..30602074,+p@chr22:30602042..30602074
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Hg19::chr5:1082038..1082051,-p4@SLC12A7
Hg19::chr5:1138370..1138374,-p@chr5:1138370..1138374
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Hg19::chr6:126240167..126240193,-p@chr6:126240167..126240193
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Hg19::chr6:160137409..160137424,+p@chr6:160137409..160137424
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Hg19::chr6:30685210..30685218,+p@chr6:30685210..30685218
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Hg19::chr8:125283938..125283961,+p2@ENST00000517482
Hg19::chr9:38170884..38170888,-p@chr9:38170884..38170888
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0015379potassium:chloride symporter activity0.0141286590560376
GO:0015377cation:chloride symporter activity0.0211904930526434
GO:0015296anion:cation symporter activity0.0458944863739359



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte1.66e-10642
CD14-positive, CD16-negative classical monocyte1.66e-10642
defensive cell1.99e-9248
phagocyte1.99e-9248
monopoietic cell1.04e-7259
monocyte1.04e-7259
monoblast1.04e-7259
promonocyte1.04e-7259
macrophage dendritic cell progenitor3.66e-7061
myeloid leukocyte4.05e-6772
myeloid lineage restricted progenitor cell1.83e-6466
granulocyte monocyte progenitor cell2.00e-6367
stuff accumulating cell3.27e-4887
myeloid cell8.02e-43108
common myeloid progenitor8.02e-43108
nongranular leukocyte8.52e-40115
leukocyte1.88e-37136
hematopoietic lineage restricted progenitor cell2.42e-35120
hematopoietic stem cell4.33e-29168
angioblastic mesenchymal cell4.33e-29168
hematopoietic oligopotent progenitor cell1.28e-28161
hematopoietic multipotent progenitor cell1.28e-28161
hematopoietic cell2.81e-27177
mesenchymal cell3.67e-11354
connective tissue cell8.26e-11361
motile cell1.44e-09386
multi fate stem cell4.76e-08427
somatic stem cell7.71e-08433
basophil1.41e-073
stem cell1.44e-07441
Uber Anatomy
Ontology termp-valuen
bone marrow2.77e-5576
bone element7.75e-5182
hematopoietic system1.01e-4798
blood island1.01e-4798
immune system2.63e-4793
skeletal element8.10e-4690
hemolymphoid system9.50e-43108
skeletal system1.16e-40100
musculoskeletal system6.35e-22167
lateral plate mesoderm8.67e-20203
mesoderm2.32e-11315
mesoderm-derived structure2.32e-11315
presumptive mesoderm2.32e-11315
connective tissue2.50e-10371


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235363.599182123557760.003862286837325890.0190495100355834
FOSL1#806137.94271594327460.005785445903376980.0260139572352344
FOSL2#235544.514720161216450.009808741154451470.0368680312902094
JUN#372554.170943064112110.004945731421922860.0231087707576146
JUNB#372648.16283537595230.001162842816154370.00794960665551785
NFYA#480044.913488186621470.007300144479678050.0301960390238463
SIRT6#51548330.7276807980050.0001180432296896320.00160357919687246
STAT3#677474.909083665338650.0002260185316605590.00249473149736812
TRIM28#1015556.196841681754170.0008567651390713570.00644898698086295



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.