Coexpression cluster:C7: Difference between revisions
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|id=C7
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{{Coexpression_clusters | {{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0625128387853364,0,0,0,0,0,0,0.191449731291012,0.0793782434714987,0.0992874467131643,0,0,0,0.0589565109853561,0,0.0943257785523457,0.229755313179946,0.149578685266771,0.28535904381024,0.942885413515291,0.869467446146925,1.0495405250267,0.376391288041361,0.360019282223445,0.371855321441455,0.138771381856642,0.104796384789156,0.223799672996739,0.452783301463467,0.358642115221847,0.41283079991681,0.560959427465818,0.661845406566668,0.644418696578103,0.334621998523167,0.195175748476722,0.351341005362286,0.876937139482848,0.828422200419531,1.0052633929417,0.205583124092593,0.323217625098021,0.412008702850566,0,0,0,0.0462331160303238,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0848314897427103,0.0440407241264263,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0|full_id=C7_CD14_Eosinophils_Neutrophils_Smooth_Basophils_Macrophage_Mast|gostat_on_coexpression_clusters=GO:0002376!immune system process!2.04931491108874e-22!6398;3937;5698;91543;3394;3600;6890;133396;4283;1520;1230;115361;6354;2634;6373;604;115362;399;56253;353376;3627;2210;861;2633;9934;64135;3428;64127;29126;5970;6355$GO:0006955!immune response!4.25542578510859e-20!6398;3937;5698;2634;6373;115362;604;353376;91543;56253;3394;3627;3600;6890;133396;2210;4283;2633;9934;64135;1520;1230;115361;6354;64127;5970;29126;6355$GO:0048869!cellular developmental process!5.52603342113195e-15!8454;90;8522;83593;26258;3142;6772;399;604;2012;56253;3394;79370;5777;837;133396;843;23405;6272;22862;6604;861;140691;64135;8651;84674;675;3428;64127;5970;1390$GO:0030154!cell differentiation!5.52603342113195e-15!8454;90;8522;83593;26258;3142;6772;399;604;2012;56253;3394;79370;5777;837;133396;843;23405;6272;22862;6604;861;140691;64135;8651;84674;675;3428;64127;5970;1390$GO:0005515!protein binding!2.57204122660213e-13!6398;8454;8522;26258;81844;11342;9246;3383;3600;6773;79836;118429;4283;140691;5359;10307;26270;1230;54386;6203;8578;6373;399;203100;604;353376;56253;3627;3708;55748;5777;837;1102;10221;23405;5156;2210;7227;6604;64135;8651;3428;675;54464;5970;29126;1390;6355;3937;571;197259;25976;1838;79370;1959;6890;843;133396;4524;5295;79364;64422;84674;6354;85403;26234;5771;23317;90;144100;11214;83593;6772;89858;3431;27299;116071;6272;7706;861;10666;84541;151636;64127$GO:0048523!negative regulation of cellular process!5.54476306940542e-10!7453;8454;90;8522;83593;399;604;3394;27299;133396;23405;7227;639;8651;675;54464;29126;5970;10865;3659;54386$GO:0048513!organ development!5.54476306940542e-10!6398;8454;90;399;604;2012;3394;3627;1959;133396;23405;5156;6272;7227;3052;6604;861;675;3428;51513$GO:0048519!negative regulation of biological process!1.96367747032347e-09!7453;8454;90;8522;83593;399;604;3394;27299;133396;23405;7227;639;8651;675;54464;29126;5970;10865;3659;54386$GO:0032502!developmental process!2.41104026218938e-09!6398;8454;8522;26258;3142;3394;1959;79370;133396;843;84002;140691;84674;90;83593;6772;604;399;56253;2012;3627;837;5777;23405;5156;6272;7227;22862;3052;6604;861;64135;8651;675;3428;64127;5970;51513;1390$GO:0048468!cell development!1.02229396478808e-08!8454;90;83593;6772;604;2012;56253;79370;5777;837;133396;843;23405;22862;140691;64135;84674;675;3428;64127;5970$GO:0065007!biological regulation!1.27329817867407e-08!6398;8454;571;8522;64857;26258;3142;9246;3383;3394;3600;1959;79370;6773;3663;133396;843;639;79364;5359;84674;1230;85403;6354;54625;7752;10865;54386;7453;90;11214;83593;6772;399;604;353376;56253;2012;56987;3627;57178;3431;27299;837;116071;10221;23405;7227;6604;861;64135;8651;675;3428;64127;54464;5970;29126;3659;8292;1390;51513$GO:0050789!regulation of biological process!6.76856693678468e-08!6398;8454;571;8522;64857;26258;3142;9246;3383;3394;3600;1959;79370;6773;3663;133396;843;639;79364;84674;85403;54625;7752;10865;54386;7453;90;11214;83593;6772;399;604;353376;56253;56987;3627;57178;3431;27299;837;116071;23405;7227;6604;861;64135;8651;675;3428;64127;54464;5970;29126;1390;8292;51513;3659$GO:0050794!regulation of cellular process!8.52794439067552e-08!6398;8454;571;8522;64857;3142;3383;3394;3600;1959;79370;6773;3663;133396;843;639;79364;84674;85403;54625;7752;10865;54386;7453;90;11214;83593;6772;399;604;353376;56253;56987;3627;57178;3431;27299;837;116071;23405;7227;6604;861;64135;8651;675;3428;64127;54464;5970;29126;1390;51513;3659$GO:0048731!system development!3.37770978161969e-07!6398;8454;90;8522;399;604;2012;3394;3627;1959;133396;23405;5156;6272;7227;3052;6604;861;84002;675;3428;51513$GO:0006952!defense response!7.76316040471521e-07!90;6373;604;353376;91543;56253;3627;6890;133396;4283;64135;1230;6354;64127;5970;6355$GO:0009615!response to virus!1.20387532241787e-06!3428;6773;5970;6772;5359;91543;64135;6355$GO:0008219!cell death!1.87141136670573e-06!8454;90;83593;6772;604;2012;56253;79370;5777;837;133396;843;140691;64135;84674;675;3428;64127;5970$GO:0016265!death!1.87141136670573e-06!8454;90;83593;6772;604;2012;56253;79370;5777;837;133396;843;140691;64135;84674;675;3428;64127;5970$GO:0042981!regulation of apoptosis!3.10792514020392e-06!8454;90;6772;604;64135;56253;84674;79370;675;3428;64127;837;5970;133396;843$GO:0043067!regulation of programmed cell death!3.38372117773017e-06!8454;90;6772;604;64135;56253;84674;79370;675;3428;64127;837;5970;133396;843$GO:0006915!apoptosis!3.51544586260349e-06!8454;90;83593;6772;604;56253;79370;5777;837;133396;843;140691;64135;84674;3428;675;64127;5970$GO:0012501!programmed cell death!3.79057652434492e-06!8454;90;83593;6772;604;56253;79370;5777;837;133396;843;140691;64135;84674;3428;675;64127;5970$GO:0005737!cytoplasm!1.41914917497262e-05!6398;1514;3937;571;5698;5130;8522;26258;1838;91543;6041;3600;79370;6773;10797;6890;197131;118429;5295;84002;10307;64422;51056;115361;1520;80830;54625;114294;5771;6203;7453;23317;29978;51312;11214;83593;2710;10613;26127;6772;399;57178;9050;3708;5777;837;10221;6272;22862;3052;7706;80124;64135;55340;8651;675;64127;54464;5970;8292$GO:0048522!positive regulation of cellular process!1.55086555391471e-05!6398;8454;90;604;353376;56253;3627;3600;837;133396;843;6604;861;675;3428;64127;5970;3659$GO:0005062!hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity!1.86435139643539e-05!3431;6773;6772$GO:0051707!response to other organism!2.03937695334459e-05!6772;5359;91543;64135;3428;6773;64127;5970;6355$GO:0048856!anatomical structure development!2.23580633340776e-05!6398;8454;90;8522;399;604;2012;3394;3627;1959;133396;23405;5156;6272;7227;3052;6604;861;84002;8651;675;3428;51513$GO:0009607!response to biotic stimulus!3.59513317289658e-05!6772;5359;91543;64135;56253;3428;6773;64127;5970;6355$GO:0009605!response to external stimulus!4.68992283973073e-05!4283;90;6373;5359;604;3627;1230;1959;675;6354;5777;64127;5970;6355$GO:0044424!intracellular part!5.42178615031973e-05!6398;8454;5698;8522;26258;3142;11342;91543;3394;3600;6773;3663;118429;84002;140691;10307;51056;115361;1520;80830;54386;6203;7453;2710;399;604;56987;57178;3708;5777;837;10221;7227;3052;6604;80124;64135;8651;3428;675;54464;5970;1390;8292;1514;3937;571;5130;25976;1838;6041;79370;1959;10797;6890;197131;639;5295;79364;64422;83666;85403;26234;54625;114294;7752;10865;5771;23317;29978;51312;11214;83593;26127;10613;6772;3431;9050;116071;6272;22862;7706;861;55340;64127;51513;3659$GO:0030099!myeloid cell differentiation!5.42178615031973e-05!3394;3428;861;133396;604$GO:0048518!positive regulation of biological process!5.42178615031973e-05!6398;8454;90;604;353376;56253;3627;3600;837;133396;843;6604;861;675;3428;64127;5970;3659$GO:0002521!leukocyte differentiation!0.00013146678893299!3428;861;133396;399;604$GO:0009611!response to wounding!0.000132130896440254!4283;90;6373;5359;604;3627;1230;6354;5777;5970;6355$GO:0007275!multicellular organismal development!0.000137037572451955!6398;8454;90;8522;3142;399;604;2012;3394;3627;1959;133396;23405;5156;6272;7227;3052;6604;861;84002;675;3428;1390;51513$GO:0032501!multicellular organismal process!0.000233225168049701!6398;8454;3937;8522;26258;3142;3394;1959;133396;4524;84002;5359;90;604;399;56253;2012;3627;23405;5156;6272;7227;3052;861;6604;10666;675;3428;64127;29126;51513;8292;1390;3659$GO:0006954!inflammatory response!0.000245767104766667!4283;90;6373;604;3627;1230;6354;5970;6355$GO:0030097!hemopoiesis!0.000293168745362596!3394;3428;861;133396;399;604$GO:0002573!myeloid leukocyte differentiation!0.000327093857030976!3428;861;133396$GO:0044464!cell part!0.000382339554254106!6398;8454;5698;8522;26258;3142;81844;11342;91543;3383;3394;3600;6773;3663;118429;84002;140691;5359;10307;51056;115361;1520;1230;80830;54386;6203;7453;55784;8578;2710;399;115362;604;353376;56253;56987;3627;57178;441168;3708;5777;837;10221;23405;5156;2210;2907;7227;3052;10184;6604;80124;64135;8651;3428;675;54464;5970;29126;55741;8292;1390;6355;1514;3937;571;3772;5130;25976;64857;1838;6041;79370;1959;10797;6890;133396;197131;84868;639;56833;5295;963;79364;64422;83666;84674;85403;26234;54625;114294;7752;5771;10865;23317;29978;51312;90;11214;83593;2634;24145;10613;26127;6772;89858;2012;3431;9050;27299;116071;6272;22862;7706;861;2633;9934;10666;55340;64127;51513;3659$GO:0001816!cytokine production!0.000394845123550258!3937;64127;3659;604;56253;10666$GO:0048534!hemopoietic or lymphoid organ development!0.000423615876747522!3394;3428;861;133396;399;604$GO:0042221!response to chemical stimulus!0.000439171963869114!4283;6373;3627;1230;675;6354;1959;64127;5970;114294;23405;6355$GO:0002520!immune system development!0.000561283977550572!3394;3428;861;133396;399;604$GO:0051704!multi-organism process!0.000590112710190111!6772;5359;91543;64135;3428;6773;64127;5970;6355$GO:0008009!chemokine activity!0.000686658409232106!3627;4283;6354;6373;6355$GO:0042379!chemokine receptor binding!0.000716159041291623!3627;4283;6354;6373;6355$GO:0007259!JAK-STAT cascade!0.000773216869787527!8651;6773;133396;6772$GO:0007249!I-kappaB kinase/NF-kappaB cascade!0.00106812224639256!6398;64127;5970;6772;399;353376$GO:0019221!cytokine and chemokine mediated signaling pathway!0.00109845940184638!8651;1230;5970;133396$GO:0006935!chemotaxis!0.00122650567475901!3627;1230;4283;6354;6373;6355$GO:0042330!taxis!0.00122650567475901!3627;1230;4283;6354;6373;6355$GO:0007243!protein kinase cascade!0.00128828572558078!6398;6772;399;353376;8651;64127;6773;133396;5970$GO:0045449!regulation of transcription!0.00148364524973606!571;90;3142;6772;399;604;3394;56987;57178;3431;1959;6773;3663;133396;116071;7227;639;6604;861;79364;675;85403;3428;54625;64127;5970;7752;1390;10865;51513;3659;54386$GO:0007260!tyrosine phosphorylation of STAT protein!0.00160842016974691!8651;133396;6772$GO:0010468!regulation of gene expression!0.00160842016974691!571;3142;3394;1959;6773;3663;133396;639;79364;85403;54625;7752;10865;54386;90;604;399;6772;56987;3431;57178;116071;23405;7227;861;6604;3428;675;64127;5970;3659;51513;1390$GO:0005622!intracellular!0.00160842016974691!6398;8454;5698;8522;26258;3142;81844;11342;91543;3394;3600;6773;3663;118429;84002;140691;10307;51056;115361;1520;80830;54386;6203;7453;2710;399;604;56987;57178;3708;5777;837;10221;23405;7227;3052;6604;80124;64135;8651;3428;675;54464;5970;8292;1390;1514;3937;571;5130;25976;1838;64857;6041;79370;1959;10797;6890;197131;639;5295;79364;64422;84674;83666;85403;26234;54625;114294;7752;10865;5771;23317;29978;51312;11214;83593;26127;10613;6772;3431;9050;116071;6272;22862;7706;861;55340;64127;51513;3659$GO:0019899!enzyme binding!0.00165020106042388!8454;64422;8651;64127;5970;5295;133396;399$GO:0005125!cytokine activity!0.00181627856557638!6398;4283;5295;6373;3627;3600;6354;6355$GO:0019219!regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.00200349311194237!571;90;3142;6772;399;604;3394;56987;57178;3431;1959;6773;3663;133396;116071;7227;639;6604;861;79364;675;85403;3428;54625;64127;5970;7752;1390;10865;51513;3659;54386$GO:0050663!cytokine secretion!0.00204946154932636!3937;64127;56253$GO:0003700!transcription factor activity!0.00204946154932636!571;8522;3142;6772;3394;1959;6773;3663;116071;7227;639;861;7706;5970;3659;51513;1390$GO:0001664!G-protein-coupled receptor binding!0.00225867132750561!3627;4283;6354;6373;6355$GO:0030224!monocyte differentiation!0.00248408607713838!3428;133396$GO:0043122!regulation of I-kappaB kinase/NF-kappaB cascade!0.00261602544262239!6398;64127;5970;399;353376$GO:0031323!regulation of cellular metabolic process!0.00265353131956912!571;3142;3394;1959;6773;3663;133396;639;79364;85403;54625;7752;10865;54386;90;604;399;6772;56987;3431;57178;116071;7227;861;6604;8651;3428;675;64127;5970;3659;51513;1390$GO:0008283!cell proliferation!0.00268156843737764!7453;8454;604;2012;3627;3600;675;3428;29126;133396;10221;5156$GO:0006366!transcription from RNA polymerase II promoter!0.00289456874401467!7227;639;6604;861;3142;6772;604;3394;6773;51513;3659$GO:0043065!positive regulation of apoptosis!0.00307094059980835!8454;3428;675;837;843;604;56253$GO:0006350!transcription!0.00309531200459305!571;90;3142;6772;399;604;3394;56987;57178;3431;1959;6773;3663;133396;116071;7227;639;6604;861;79364;675;85403;3428;54625;64127;5970;7752;1390;10865;51513;3659;54386$GO:0043068!positive regulation of programmed cell death!0.00312110801910146!8454;3428;675;837;843;604;56253$GO:0007626!locomotory behavior!0.00312110801910146!3627;1230;4283;6354;6373;6355$GO:0007242!intracellular signaling cascade!0.00314355404862467!6398;55784;11214;83593;64857;6772;399;604;353376;5341;6773;5777;51676;133396;5295;55647;1230;8651;64127;5970$GO:0019222!regulation of metabolic process!0.00325342291760973!571;3142;9246;3394;1959;6773;3663;133396;639;79364;85403;54625;7752;10865;54386;90;604;399;6772;56987;3431;57178;116071;7227;861;6604;8651;3428;675;64127;5970;3659;51513;1390$GO:0006512!ubiquitin cycle!0.00332480907414649!8454;80124;9246;64422;26270;8651;26234;51676;84640;197131$GO:0019207!kinase regulator activity!0.00395858995952148!3627;8651;5295;10221;399$GO:0009887!organ morphogenesis!0.00401880590138388!8454;3052;90;6604;861;51513;23405;5156$GO:0042301!phosphate binding!0.00506583000517576!10797;5970$GO:0043231!intracellular membrane-bound organelle!0.0057660237224233!6398;1514;571;5698;25976;26258;3142;11342;91543;6041;3394;3600;1959;6773;10797;3663;6890;118429;639;84002;79364;140691;83666;51056;1520;85403;54625;114294;7752;10865;54386;29978;51312;11214;2710;10613;6772;604;56987;57178;3431;3708;5777;116071;6272;7227;22862;3052;6604;861;80124;64135;55340;675;3428;5970;51513;1390;3659$GO:0043227!membrane-bound organelle!0.0057660237224233!6398;1514;571;5698;25976;26258;3142;11342;91543;6041;3394;3600;1959;6773;10797;3663;6890;118429;639;84002;79364;140691;83666;51056;1520;85403;54625;114294;7752;10865;54386;29978;51312;11214;2710;10613;6772;604;56987;57178;3431;3708;5777;116071;6272;7227;22862;3052;6604;861;80124;64135;55340;675;3428;5970;51513;1390;3659$GO:0001775!cell activation!0.00598478165379157!3937;133396;29126;399;5359;604$GO:0007610!behavior!0.00598478165379157!3627;1230;1959;4283;6354;6373;6355$GO:0006917!induction of apoptosis!0.00632486519487323!8454;3428;675;837;843;56253$GO:0012502!induction of programmed cell death!0.00640746349540556!8454;3428;675;837;843;56253$GO:0043283!biopolymer metabolic process!0.00718292412371004!8454;1845;571;5698;197259;25976;3142;9246;6041;3394;1959;6773;3663;51676;133396;84640;197131;639;5295;84002;79364;64422;26270;26234;85403;54625;7752;5771;10865;54386;7453;23317;29978;90;6772;604;56987;57178;3431;5777;116071;23405;5156;7227;6604;861;80124;8651;675;3428;5970;1390;51513;3659$GO:0019901!protein kinase binding!0.00826137519618881!8651;64127;5970;133396$GO:0045786!negative regulation of progression through cell cycle!0.00826137519618881!8454;8522;54464;83593;3659;604$GO:0042771!DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis!0.00833277519435027!3428;675$GO:0008629!induction of apoptosis by intracellular signals!0.00842126389558695!8454;3428;675$GO:0051329!interphase of mitotic cell cycle!0.00866460400587848!8454;675;90;604$GO:0006355!regulation of transcription, DNA-dependent!0.00880292440556492!571;3142;6772;604;3394;56987;57178;3431;1959;6773;3663;133396;116071;7227;639;6604;861;79364;85403;675;3428;54625;5970;7752;1390;10865;51513;3659$GO:0007267!cell-cell signaling!0.00903197713829527!4283;26258;6373;3627;3600;1230;6354;1959;8292;6355$GO:0009967!positive regulation of signal transduction!0.00914381392986915!6398;64127;5970;133396;353376$GO:0003950!NAD+ ADP-ribosyltransferase activity!0.00935952387996985!83666;54625;25976$GO:0044237!cellular metabolic process!0.0094322306170733!8454;5698;3142;9246;3394;6773;79836;3663;51676;84002;51056;26270;1520;80830;9605;54386;6203;7453;8578;2710;399;203100;604;56987;57178;55748;5777;837;23405;5156;7227;6604;80124;8651;3428;675;5970;8292;1390;1514;571;1845;197259;5130;25976;6041;1959;10797;843;133396;84640;197131;4524;639;5295;79364;64422;85403;26234;54625;114294;7752;10865;5771;23317;29978;90;6772;80832;3431;27299;116071;861;64127;51513;3659$GO:0042516!regulation of tyrosine phosphorylation of Stat3 protein!0.00979211284503215!8651;133396$GO:0051325!interphase!0.00997267026623332!8454;675;90;604$GO:0042503!tyrosine phosphorylation of Stat3 protein!0.0118179542215812!8651;133396$GO:0018108!peptidyl-tyrosine phosphorylation!0.0118179542215812!8651;133396;6772$GO:0019210!kinase inhibitor activity!0.0118179542215812!8651;10221;399$GO:0008639!small protein conjugating enzyme activity!0.0121518495503619!64422;26270;26234;197131;9246$GO:0009966!regulation of signal transduction!0.0125053653937382!6398;90;11214;64857;399;604;353376;8651;64127;133396;5970$GO:0006351!transcription, DNA-dependent!0.0126269066280285!571;3142;6772;604;3394;56987;57178;3431;1959;6773;3663;133396;116071;7227;639;6604;861;79364;85403;675;3428;54625;5970;7752;1390;10865;51513;3659$GO:0043170!macromolecule metabolic process!0.0127504889060913!8454;5698;3142;9246;3394;6773;79836;3663;51676;84002;51056;26270;1520;80830;54386;6203;7453;8578;2710;604;203100;56987;57178;55748;5777;837;23405;5156;7227;6604;80124;8651;675;3428;5970;1390;1514;571;1845;197259;25976;6041;1959;843;133396;84640;197131;639;5295;79364;64422;85403;26234;54625;7752;10865;5771;23317;29978;90;6772;80832;3431;27299;116071;861;64127;51513;3659$GO:0032774!RNA biosynthetic process!0.0127504889060913!571;3142;6772;604;3394;56987;57178;3431;1959;6773;3663;133396;116071;7227;639;6604;861;79364;85403;675;3428;54625;5970;7752;1390;10865;51513;3659$GO:0018212!peptidyl-tyrosine modification!0.0127788900948737!8651;133396;6772$GO:0019900!kinase binding!0.0127946243405622!8651;64127;5970;133396$GO:0043123!positive regulation of I-kappaB kinase/NF-kappaB cascade!0.0127946243405622!6398;64127;5970;353376$GO:0005159!insulin-like growth factor receptor binding!0.0129652240375776!8651;5295$GO:0007090!regulation of S phase of mitotic cell cycle!0.0129652240375776!675;604$GO:0000074!regulation of progression through cell cycle!0.0129652240375776!8454;675;8522;54464;83593;3659;604$GO:0051726!regulation of cell cycle!0.0141584581728631!8454;675;8522;54464;83593;3659;604$GO:0016070!RNA metabolic process!0.014163468674623!7453;23317;571;3142;6772;604;6041;3394;56987;57178;3431;1959;6773;3663;133396;116071;23405;7227;639;6604;861;79364;675;85403;3428;54625;5970;7752;1390;10865;51513;3659$GO:0042127!regulation of cell proliferation!0.0147541183613308!7453;8454;604;3627;3600;675;29126;133396$GO:0045321!leukocyte activation!0.0152986239648343!3937;133396;29126;399;604$GO:0042509!regulation of tyrosine phosphorylation of STAT protein!0.0172060680678069!8651;133396$GO:0050715!positive regulation of cytokine secretion!0.0172060680678069!64127;56253$GO:0002252!immune effector process!0.0172955303071828!5970;604;91543;56253$GO:0051239!regulation of multicellular organismal process!0.0176493784134082!90;64127;133396;29126;604;56253$GO:0031324!negative regulation of cellular metabolic process!0.0185120474722734!3394;8651;7227;675;639;10865;604$GO:0043687!post-translational protein modification!0.0185120474722734!8454;1845;90;197259;25976;6772;9246;6041;5777;51676;133396;84640;197131;5156;80124;64422;26270;8651;26234;5771$GO:0045087!innate immune response!0.0190389160679225!64127;353376;64135;56253$GO:0009595!detection of biotic stimulus!0.0190389160679225!64127;56253$GO:0006950!response to stress!0.0212141190446014!4283;90;6373;5359;604;3627;1230;3428;675;6354;5777;5970;6355$GO:0002697!regulation of immune effector process!0.0212141190446014!604;56253$GO:0046425!regulation of JAK-STAT cascade!0.0212141190446014!8651;133396$GO:0033261!regulation of progression through S phase!0.0212141190446014!675;604$GO:0009306!protein secretion!0.0224149903251553!3937;64127;56253$GO:0045892!negative regulation of transcription, DNA-dependent!0.0229953718946196!3394;7227;639;10865;604$GO:0030330!DNA damage response, signal transduction by p53 class mediator!0.0229953718946196!3428;675$GO:0050707!regulation of cytokine secretion!0.0229953718946196!64127;56253$GO:0050714!positive regulation of protein secretion!0.0229953718946196!64127;56253$GO:0051607!defense response to virus!0.0229953718946196!5970;91543$GO:0008234!cysteine-type peptidase activity!0.0229953718946196!1514;1520;837;843;84640;80124$GO:0007167!enzyme linked receptor protein signaling pathway!0.0232071371601787!8651;3937;90;5295;133396;5156$GO:0007154!cell communication!0.0236074625618326!6398;3937;64857;26258;3600;1959;6773;51676;133396;4283;5295;963;1230;6354;90;55784;11214;83593;6373;6772;399;604;353376;5341;3627;3708;27299;5777;5156;55647;9934;10666;8651;64127;5970;29126;1390;8292;6355$GO:0005102!receptor binding!0.0236074625618326!6398;4283;6604;5295;6373;56253;3627;8651;3600;6354;27299;6355$GO:0007169!transmembrane receptor protein tyrosine kinase signaling pathway!0.0249592671797786!8651;3937;5295;133396;5156$GO:0000084!S phase of mitotic cell cycle!0.0249592671797786!675;604$GO:0005615!extracellular space!0.0250978341999601!6398;4283;6373;3627;3600;6354;8292;6355$GO:0044267!cellular protein metabolic process!0.0251151474995319!8454;1514;1845;5698;197259;25976;9246;6041;79836;51676;133396;843;84640;197131;84002;64422;51056;26270;1520;80830;26234;5771;6203;7453;23317;29978;90;8578;203100;6772;80832;55748;837;27299;5777;5156;80124;8651;3659$GO:0044238!primary metabolic process!0.026513121765228!8454;5698;3142;9246;3394;6773;79836;3663;51676;84002;51056;26270;1520;80830;9605;54386;6203;7453;8578;2710;399;203100;604;56987;57178;55748;5777;837;23405;5156;7227;6604;80124;8651;3428;675;5970;8292;1390;1514;571;1845;197259;5130;25976;6041;1959;843;133396;84640;197131;4524;639;5295;79364;64422;85403;26234;54625;7752;10865;5771;23317;29978;90;6772;80832;3431;27299;116071;861;64127;51513;3659$GO:0006357!regulation of transcription from RNA polymerase II promoter!0.0279182990654178!3394;6773;639;6604;861;3659;604$GO:0045934!negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.0292502552616485!3394;7227;675;639;10865;604$GO:0043412!biopolymer modification!0.0292502552616485!8454;29978;1845;90;197259;25976;6772;9246;6041;5777;51676;133396;84640;197131;5156;5295;84002;80124;64422;26270;8651;26234;5771$GO:0007281!germ cell development!0.0292502552616485!675;90$GO:0008630!DNA damage response, signal transduction resulting in induction of apoptosis!0.0292502552616485!3428;675$GO:0051250!negative regulation of lymphocyte activation!0.0292502552616485!29126;604$GO:0030155!regulation of cell adhesion!0.0292502552616485!27299;604;3383$GO:0008285!negative regulation of cell proliferation!0.0308870006884819!7453;8454;675;29126;604$GO:0044260!cellular macromolecule metabolic process!0.0309715516136739!8454;1514;1845;5698;197259;25976;9246;6041;79836;51676;133396;843;84640;197131;84002;64422;51056;26270;1520;80830;26234;5771;6203;7453;23317;29978;90;8578;203100;6772;80832;55748;837;27299;5777;5156;80124;8651;3659$GO:0009892!negative regulation of metabolic process!0.0310067445755624!3394;8651;7227;675;639;10865;604$GO:0019538!protein metabolic process!0.0312750701736084!8454;1514;1845;5698;197259;25976;9246;6041;79836;51676;133396;843;84640;197131;84002;64422;51056;26270;1520;80830;26234;5771;6203;7453;23317;29978;90;8578;6772;203100;80832;55748;837;27299;5777;5156;80124;8651;64127;3659$GO:0004197!cysteine-type endopeptidase activity!0.0312750701736084!1514;1520;837;843$GO:0051320!S phase!0.0312750701736084!675;604$GO:0051047!positive regulation of secretion!0.0312750701736084!64127;56253$GO:0007165!signal transduction!0.0312750701736084!6398;3937;64857;3600;6773;51676;133396;4283;5295;963;1230;6354;90;55784;11214;83593;6373;6772;604;399;353376;5341;3627;3708;27299;5777;5156;55647;9934;10666;8651;64127;29126;5970;1390;6355$GO:0000060!protein import into nucleus, translocation!0.0312750701736084!6772;604$GO:0006464!protein modification process!0.0312750701736084!8454;29978;1845;90;197259;25976;6772;9246;6041;5777;51676;133396;84640;197131;5156;84002;80124;64422;26270;8651;26234;5771$GO:0017001!antibiotic catabolic process!0.0312750701736084!114294$GO:0008917!lipopolysaccharide N-acetylglucosaminyltransferase activity!0.0312750701736084!84002$GO:0048407!platelet-derived growth factor binding!0.0312750701736084!5156$GO:0016804!prolyl aminopeptidase activity!0.0312750701736084!51056$GO:0048294!negative regulation of isotype switching to IgE isotypes!0.0312750701736084!604$GO:0008457!beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity!0.0312750701736084!84002$GO:0030653!beta-lactam antibiotic metabolic process!0.0312750701736084!114294$GO:0033595!response to genistein!0.0312750701736084!675$GO:0033600!negative regulation of mammary gland epithelial cell proliferation!0.0312750701736084!675$GO:0002355!detection of tumor cell!0.0312750701736084!56253$GO:0005018!platelet-derived growth factor alpha-receptor activity!0.0312750701736084!5156$GO:0030423!RNA interference, targeting of mRNA for destruction!0.0312750701736084!23405$GO:0032498!detection of muramyl dipeptide!0.0312750701736084!64127$GO:0030655!beta-lactam antibiotic catabolic process!0.0312750701736084!114294$GO:0030852!regulation of granulocyte differentiation!0.0312750701736084!861$GO:0043379!memory T cell differentiation!0.0312750701736084!604$GO:0030854!positive regulation of granulocyte differentiation!0.0312750701736084!861$GO:0043380!regulation of memory T cell differentiation!0.0312750701736084!604$GO:0008800!beta-lactamase activity!0.0312750701736084!114294$GO:0032500!muramyl dipeptide binding!0.0312750701736084!64127$GO:0032926!negative regulation of activin receptor signaling pathway!0.0312750701736084!90$GO:0035030!phosphoinositide 3-kinase complex, class IA!0.0312750701736084!5295$GO:0004408!holocytochrome-c synthase activity!0.0312750701736084!3052$GO:0043031!negative regulation of macrophage activation!0.0312750701736084!133396$GO:0042523!positive regulation of tyrosine phosphorylation of Stat5 protein!0.0312750701736084!133396$GO:0048250!mitochondrial iron ion transport!0.0312750701736084!51312$GO:0030422!RNA interference, production of siRNA!0.0312750701736084!23405$GO:0004218!cathepsin S activity!0.0312750701736084!1520$GO:0032490!detection of molecule of bacterial origin!0.0312750701736084!64127$GO:0032495!response to muramyl dipeptide!0.0312750701736084!64127$GO:0033593!BRCA2-MAGE-D1 complex!0.0312750701736084!675$GO:0032499!detection of peptidoglycan!0.0312750701736084!64127$GO:0032494!response to peptidoglycan!0.0312750701736084!64127$GO:0045829!negative regulation of isotype switching!0.0312750701736084!604$GO:0051092!activation of NF-kappaB transcription factor!0.0326920427182347!64127;5970$GO:0006508!proteolysis!0.0346114617683344!8454;1514;5698;203100;51056;1520;26270;55748;79836;27299;837;843;84640$GO:0016787!hydrolase activity!0.0346114617683344!1514;1845;5698;2634;203100;115362;6041;26090;55748;5777;10797;79836;27299;837;6890;843;84640;23405;2633;80124;64135;51056;1520;115361;54464;114294;5771;55741$GO:0016763!transferase activity, transferring pentosyl groups!0.0377749291994716!83666;54625;25976$GO:0050865!regulation of cell activation!0.0377749291994716!133396;29126;604$GO:0050708!regulation of protein secretion!0.0403822404085943!64127;56253$GO:0007162!negative regulation of cell adhesion!0.0403822404085943!27299;604$GO:0000151!ubiquitin ligase complex!0.0409576468755775!8454;64422;26234$GO:0016607!nuclear speck!0.0409576468755775!57178;85403;140691$GO:0043226!organelle!0.0409576468755775!6398;5698;26258;3142;11342;91543;3394;3600;6773;3663;118429;84002;140691;51056;1520;54386;6203;2710;604;56987;57178;3708;5777;7227;3052;6604;80124;64135;675;3428;5970;1390;1514;571;1838;25976;6041;79370;1959;10797;6890;639;79364;83666;85403;54625;114294;10865;7752;29978;51312;11214;83593;10613;6772;3431;116071;6272;22862;861;55340;64127;3659;51513$GO:0004842!ubiquitin-protein ligase activity!0.0417714048545602!26270;26234;197131;9246$GO:0042157!lipoprotein metabolic process!0.0417714048545602!80830;8578;80832$GO:0002274!myeloid leukocyte activation!0.0420157996550589!3937;133396$GO:0003705!RNA polymerase II transcription factor activity, enhancer binding!0.0420157996550589!3394;5970$GO:0010467!gene expression!0.0421964868119728!571;3142;6041;3394;1959;6773;3663;133396;639;79364;85403;54625;7752;10865;54386;6203;7453;23317;90;604;399;6772;56987;57178;3431;116071;23405;7227;861;6604;3428;675;64127;5970;3659;51513;1390$GO:0007276!gamete generation!0.0432736196148453!22862;675;90;1390;604$GO:0050730!regulation of peptidyl-tyrosine phosphorylation!0.044261331185689!8651;133396$GO:0048754!branching morphogenesis of a tube!0.044261331185689!90;23405$GO:0022402!cell cycle process!0.0450697953688119!8454;90;8522;83593;604;675;54464;3659$GO:0009653!anatomical structure morphogenesis!0.0464387897537615!8454;3052;90;6604;861;604;2012;8651;51513;23405;5156$GO:0003677!DNA binding!0.0484527379444247!571;8522;3142;6772;604;3394;56987;3431;1959;6773;3663;116071;7227;639;7706;861;64135;675;3428;54464;5970;1390;10865;51513;3659;54386$GO:0051091!positive regulation of transcription factor activity!0.0484527379444247!64127;5970$GO:0005057!receptor signaling protein activity!0.0484527379444247!3431;90;6773;6772$GO:0045941!positive regulation of transcription!0.0484527379444247!90;6604;861;133396;3659$GO:0033598!mammary gland epithelial cell proliferation!0.0484527379444247!675$GO:0045629!negative regulation of T-helper 2 cell differentiation!0.0484527379444247!604$GO:0032764!negative regulation of mast cell cytokine production!0.0484527379444247!604$GO:0031050!dsRNA fragmentation!0.0484527379444247!23405$GO:0004487!methylenetetrahydrofolate dehydrogenase (NAD+) activity!0.0484527379444247!10797$GO:0048641!regulation of skeletal muscle development!0.0484527379444247!90$GO:0006581!acetylcholine catabolic process!0.0484527379444247!8292$GO:0016246!RNA interference!0.0484527379444247!23405$GO:0006978!DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator!0.0484527379444247!675$GO:0002902!regulation of B cell apoptosis!0.0484527379444247!604$GO:0030349!syntaxin-13 binding!0.0484527379444247!26258$GO:0004217!cathepsin L activity!0.0484527379444247!1514$GO:0045029!UDP-activated nucleotide receptor activity!0.0484527379444247!9934$GO:0033599!regulation of mammary gland epithelial cell proliferation!0.0484527379444247!675$GO:0045623!negative regulation of T-helper cell differentiation!0.0484527379444247!604$GO:0002903!negative regulation of B cell apoptosis!0.0484527379444247!604$GO:0002634!regulation of germinal center formation!0.0484527379444247!604$GO:0035196!miRNA-mediated gene silencing, production of miRNAs!0.0484527379444247!23405$GO:0001507!acetylcholine catabolic process in synaptic cleft!0.0484527379444247!8292$GO:0035024!negative regulation of Rho protein signal transduction!0.0484527379444247!604$GO:0004105!choline-phosphate cytidylyltransferase activity!0.0484527379444247!5130$GO:0048478!replication fork protection!0.0484527379444247!675$GO:0019005!SCF ubiquitin ligase complex!0.0484527379444247!8454$GO:0035195!miRNA-mediated gene silencing!0.0484527379444247!23405$GO:0043559!insulin binding!0.0484527379444247!5295$GO:0042772!DNA damage response, signal transduction resulting in transcription!0.0484527379444247!675$GO:0048179!activin receptor complex!0.0484527379444247!90$GO:0004178!leucyl aminopeptidase activity!0.0484527379444247!51056$GO:0042522!regulation of tyrosine phosphorylation of Stat5 protein!0.0484527379444247!133396$GO:0046653!tetrahydrofolate metabolic process!0.0484527379444247!10797$GO:0007346!regulation of progression through mitotic cell cycle!0.0484527379444247!675;604$GO:0001763!morphogenesis of a branching structure!0.0484527379444247!90;23405$GO:0008286!insulin receptor signaling pathway!0.0484527379444247!8651;5295$GO:0008233!peptidase activity!0.0485189475958085!1514;5698;80124;203100;1520;51056;55748;79836;27299;837;843;84640$GO:0006606!protein import into nucleus!0.0490259751643505!7227;6772;604|id=C7|kegg_enrichment=hsa04621;NOD-like_receptor_signaling_pathway;9.09E-08!hsa04062;Chemokine_signaling_pathway;5.72E-06!hsa04060;Cytokine-cytokine_receptor_interaction;1.19E-05!hsa04622;RIG-I-like_receptor_signaling_pathway;2.18E-05!hsa04620;Toll-like_receptor_signaling_pathway;5.96E-05!hsa01100;Metabolic_pathways;0.000161136!hsa04670;Leukocyte_transendothelial_migration;0.0002092|ontology_enrichment_celltype=CL:0000860!5.60e-140!42;CL:0002057!5.60e-140!42;CL:0000473!9.33e-122!48;CL:0000234!9.33e-122!48;CL:0002194!3.08e-96!59;CL:0000576!3.08e-96!59;CL:0000040!3.08e-96!59;CL:0000559!3.08e-96!59;CL:0002009!6.06e-93!61;CL:0000839!1.44e-85!66;CL:0000557!3.18e-84!67;CL:0000766!5.34e-83!72;CL:0000325!1.55e-64!87;CL:0000763!1.31e-53!108;CL:0000049!1.31e-53!108;CL:0002087!3.29e-53!115;CL:0000738!6.32e-47!136;CL:0002031!1.03e-44!120;CL:0000037!7.05e-37!168;CL:0000566!7.05e-37!168;CL:0000988!1.06e-34!177;CL:0002032!4.49e-34!161;CL:0000837!4.49e-34!161;CL:0000134!3.05e-14!354;CL:0002320!7.68e-14!361;CL:0000219!1.99e-12!386;CL:0000048!1.07e-10!427;CL:0000723!1.85e-10!433;CL:0000034!3.77e-10!441;CL:0000226!5.61e-08!3;CL:0000842!5.61e-08!3|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0002371!1.09e-73!76;UBERON:0001474!6.21e-68!82;UBERON:0002390!2.20e-63!98;UBERON:0003061!2.20e-63!98;UBERON:0004765!1.95e-61!90;UBERON:0002405!2.76e-59!93;UBERON:0002193!5.14e-57!108;UBERON:0001434!9.21e-55!100;UBERON:0002204!1.68e-30!167;UBERON:0003081!1.34e-27!203;UBERON:0000926!1.43e-15!315;UBERON:0004120!1.43e-15!315;UBERON:0006603!1.43e-15!315;UBERON:0002384!2.71e-13!371|pathway_enrichment=4.02998118128828e-05;0.00141721004875304;9;265;Cytokine-cytokine receptor interaction (KEGG):04060!2.83362949156361e-07;2.56241066879967e-05;10;189;Chemokine signaling pathway (KEGG):04062!0.000142415808891857;0.00360596828114183;6;128;Osteoclast differentiation (KEGG):04380!3.26488961192038e-06;0.0001722229270288;7;102;Toll-like receptor signaling pathway (KEGG):04620!7.6754234857827e-05;0.00211241002891324;5;71;RIG-I-like receptor signaling pathway (KEGG):04622!0.000400315152011088;0.00873791349044892;6;155;Jak-STAT signaling pathway (KEGG):04630!0.000190417894746639;0.00446424175461565;6;135;Hepatitis C (KEGG):05160!0.00144381959924493;0.0247010217924876;5;134;Measles (KEGG):05162!1.4608798515914e-07;1.84947389211471e-05;10;176;Influenza A (KEGG):05164!0.000913001698959126;0.0165122878697465;4;70;Pancreatic cancer (KEGG):05212!6.69102128324949e-05;0.00192518930558951;5;69;IL-5 Signaling Pathway (Wikipathways):WP127!0.000104974659925711;0.00276870665554062;4;40;NOD pathway (Wikipathways):WP1433!2.18961022332174e-07;2.31003878560444e-05;9;140;Regulation of toll-like receptor signaling pathway (Wikipathways):WP1449!0.000613193606796779;0.0121297360344488;4;63;Folate Metabolism (Wikipathways):WP176!0.00265104168519505;0.0390257996913597;5;154;Integrated Breast Cancer Pathway (Wikipathways):WP1984!0.00249377294623911;0.0375847208326037;3;44;IL-7 Signaling Pathway (Wikipathways):WP205!6.36805878560101e-05;0.00191951486251687;7;161;B Cell Receptor Signaling Pathway (Wikipathways):WP23!1.42675801788839e-05;0.000602091883548901;6;85;Apoptosis (Wikipathways):WP254!0.000864927440927483;0.0161029138266793;4;69;Kit Receptor Signaling Pathway (Wikipathways):WP304!4.65289416476579e-05;0.00155014842436671;5;64;IL-4 signaling Pathway (Wikipathways):WP395!0.000853068521147919;0.0161029138266793;6;179;EGFR1 Signaling Pathway (Wikipathways):WP437!4.83471710190053e-07;3.8254699068788e-05;7;77;IL-2 Signaling Pathway (Wikipathways):WP49!2.49068494027146e-05;0.000927413863054021;4;28;Interferon type I (Wikipathways):WP585!0.000384721339507335;0.00869745028243368;5;100;Senescence and Autophagy (Wikipathways):WP615!1.01583700518889e-14;3.21512412142283e-12;11;50;Type II interferon signaling (IFNG) (Wikipathways):WP619!0.000175566491294813;0.00427436880729295;6;133;T Cell Receptor Signaling Pathway (Wikipathways):WP69!3.26488961192038e-06;0.0001722229270288;7;102;Toll-like receptor signaling pathway (Wikipathways):WP75!1.08374208480388e-18;6.86008739680854e-16;28;511;Signaling in Immune system (Reactome):REACT_6900!0.00243356043581403;0.0375717989236654;6;220;Signalling by NGF (Reactome):REACT_11061!0.000533073878378581;0.0112478588337881;14;816;TGF beta receptor up reg. targets (Netpath):NetPath_7!7.66592931437817e-07;5.39170361777931e-05;18;740;TGF beta receptor down reg. targets (Netpath):NetPath_7!0.000582751631961468;0.0118994123558584;13;728;TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9!2.25351860978225e-05;0.000891548299995101;9;246;B Cell Receptor up reg. targets (Netpath):NetPath_12!5.43508521681929e-06;0.000264646841711278;8;155;IL-1 up reg. targets (Netpath):NetPath_13!8.15146157745929e-08;1.28996879463293e-05;15;433;IL-2 up reg. targets (Netpath):NetPath_14!0.00237036350084465;0.0375110024008666;7;295;IL-2 down reg. targets (Netpath):NetPath_14!0.00189399256404034;0.0307409562317317;3;40;IL-3 up reg. targets (Netpath):NetPath_15!6.13559192634185e-05;0.00191951486251687;8;217;IL-4 up reg. targets (Netpath):NetPath_16!1.40493400028764e-06;8.89323222182073e-05;7;90;IL-4 down reg. targets (Netpath):NetPath_16!5.62565482669598e-10;1.18701316843285e-07;11;131;IL-5 up reg. targets (Netpath):NetPath_17!1.00541308434114e-05;0.000454590344562815;6;80;IL-6 up reg. targets (Netpath):NetPath_18!0.00323973424938462;0.0466079949968287;2;14;IL-7 down reg. targets (Netpath):NetPath_19!0.00175981622123175;0.0293148333694657;3;39;{CASP3,41} (Static Module):NA!0.000945038368404978;0.0166169246444542;9;406;{GRB2,414} (Static Module):NA|tf_chipseq_enrich=BATF#10538;248:3.19109077891775:1.24244916686753e-57:1.09042141628973e-54!BCL11A#53335;200:2.99730112029657:2.40232457439097e-42:1.45026807066369e-39!BCL3#602;77:1.40524401261904:0.00220456305381441:0.0127023259835222!CEBPB#1051;456:1.92014966580883:1.64063903543628e-43:1.0322090374815e-40!EBF1#1879;369:1.7361258670808:4.64464008168152e-26:1.54978135939532e-23!EP300#2033;481:1.72121815653109:4.25826606405863e-34:2.01234864010959e-31!FOS#2353;443:2.10570216684639:2.19748068397135e-52:1.72558409889687e-49!FOSL1#8061;155:3.25177224302051:9.24093415956857e-37:4.82556961345591e-34!FOSL2#2355;157:1.40414236392825:1.59338949133812e-05:0.000372536389267656!GATA1#2623;214:1.53296668926217:4.93788614951882e-10:4.78393220379959e-08!GATA2#2624;332:2.2352442343053:2.5570165495546e-43:1.58959673463651e-40!GATA3#2625;91:1.30930955547055:0.00644035383907289:0.0279956761258193!IRF4#3662;199:2.30374433421135:3.81692445629669e-27:1.33323001100726e-24!JUN#3725;394:2.60436064542024:3.05383381663373e-69:3.1893934997541e-66!JUNB#3726;185:2.99153039728838:4.84752586986393e-39:2.72188577592859e-36!JUND#3727;433:1.59994162008989:8.37287400792207e-24:2.549430287211e-21!KAT2A#2648;8:2.60365557316429:0.0130003252839428:0.0461298872805932!MAFF#23764;81:2.40969037278688:1.2545627204091e-12:1.74700367942408e-10!MAFK#7975;182:2.60556441156104:5.56789338773594e-31:2.30756038699109e-28!MAX#4149;353:1.20324991795009:0.000113215104947069:0.00155090140943953!MEF2A#4205;229:2.26740616920681:2.69160030927219e-30:1.08956606472899e-27!MEF2C#4208;93:2.0295594124744:2.67904702713271e-10:2.72706620337927e-08!NFE2#4778;46:1.87606761224244:5.52708024081968e-05:0.000935411980669206!NFKB1#4790;488:1.4147781040711:1.70553836395092e-16:3.39285183224133e-14!NR3C1#2908;161:1.2734584027041:0.00115020753324271:0.00786683199504488!POU2F2#5452;250:1.20260486763636:0.00134023310053875:0.0088781304571335!PRDM1#639;50:3.48206433643584:8.63467645706071e-14:1.36223107930357e-11!RXRA#6256;120:1.27255893116534:0.0047942217639784:0.0225268244391119!SIRT6#51548;22:1.78554933321741:0.00756967469037177:0.0312009335775411!SMARCA4#6597;22:1.82189639343557:0.00606812667873771:0.0268446747797648!SMARCC1#6599;89:2.05284679315753:3.75689865638623e-10:3.73327058776709e-08!SPI1#6688;486:2.10633979141154:2.89281382676076e-58:2.67365117923068e-55!SRF#6722;178:1.29735749110717:0.000270607926726075:0.00288889106197941!STAT1#6772;475:5.19578925576842:1.13825246312554e-198:4.75511795985471e-195!STAT2#6773;192:6.61946332160413:2.66911657782645e-94:3.98228380388024e-91!STAT3#6774;667:3.70654154944632:4.89242193498118e-207:2.32254388394318e-203!TAL1#6886;118:1.8618577749276:1.95548864996546e-10:2.03011211842687e-08!TCF12#6938;215:1.20782353617014:0.00241559468734663:0.013614802674139!USF2#7392;177:1.21480134028384:0.00462770818496673:0.0218535546721713|tfbs_overrepresentation=1,0.963038,1,0.99943,0.000350928,1,0.99973,1,0.99372,0.999713,0.944502,0.941394,0.680172,0.998754,0.995127,0.997791,1,0.996552,0.789422,0.384417,1,7.79638e-06,0.999996,0.988949,0.982442,1,0.0253728,1,0.854476,0.997988,1,0.999798,0.807994,0.619348,0.999998,0.396009,1,0.988416,0.990793,0.999996,0.992244,0.988213,0.99999,0.990563,1,0.247,0.999179,0.999911,0.999839,0.999883,0.810637,0.905292,0.980428,0.999708,1,0.957675,0.999519,1,1,0.999995,6.74631e-06,1,0.0117475,0.772331,0.957636,0.154719,1,0.999939,1,1,1,0.99629,0.999999,0.27372,0.949637,0.983787,0.999824,0.999998,0.999951,0.943386,0.84027,0.554055,0.996268,0.998934,1,1,0.999974,1,1,0.999531,6.57031e-07,0.914376,1,0.956445,1,0.974193,1,0.999994,1,1,0.999999,1,0.820766,0.994098,1,0.98807,0.9985,1,1,1,1,0.999933,0.856016,0.987331,0.998987,0.998152,0.898676,0.998162,1,0.999506,1,1,1,0.981408,0.954707,0.984761,0.999811,0.721293,0.999874,0.999991,0.999998,0.999998,1,0.100932,0.892627,0.950127,0.0346215,0.99999,0.999893,0.71285,0.989793,0.99995,0.806239,0.868186,1,0.999277,0.999994,0.999931,0.999928,0.999985,1,0.977855,1,0.999815,1,0.999878,0.214533,0.997057,0.999879,0.999999,1,0.999745,1,1,1,0.935818,0.999641,0.893922,0.985775,0.999308,0.999565,1,1,0.999983,0.999982,0.958949,0.999932,0.965906,0.999998,0.914726,0.947441,0.577678,0.999878,1,0.999999,0.999999,0.23866,0.855985,0.999972,1,0.999999,0.981826,1,1,0.874959,0.999983,1,0.860138,1,1,0.937117,0.993989,0.999914,0.998185,0.991283,0.9999,1,0.999928,0.999983,1,0.999971,0.000742906,0.999929,1,1,1,0.996576,0.999977,0.999997,0.969532,0.0369842,0.999972,0.999913,1,0.926966,0.998406,0.999997,0.974642,0.999484,0.940403,1,1,0.523261,0.998548,0.996042,1,0.0190855,1,0.999983,1,1,1,0.999827,0.99981,0.999534,1,0.993098,0.999998,0.999388,0.999995,0.999997,1,1,0.992003,0.712797,1,1,1,0.999999,1,0.894337,1,1,0.999999,0.993008,0.742403,0.996968,5.15541e-05,3.28408e-06,1,1,1,1,1,0.999999,0.991553,1,1,1,1,0.999785,1,1,1,1,1,0.0489379,1,1,0.99809,1,0.998485,1,1,1,1,0.999966,1,1,1,1,1,0.998366,1,0.999916,1,0.276525,1,1,1,0.999996,1,1,1,1,1,1,1,1,0.999999,1,1,1,0.998485,1,1,0.999974,1,1,1,1,1,1,0.997917,1,1,1,1,1,0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| ||
|full_id=C7_CD14_Eosinophils_Neutrophils_Smooth_Basophils_Macrophage_Mast | |||
|id=C7 | |||
}} |
Latest revision as of 10:03, 17 September 2013
Full id: C7_CD14_Eosinophils_Neutrophils_Smooth_Basophils_Macrophage_Mast
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
4.02998118128828e-05 | 0.00141721004875304 | 9 | 265 | Cytokine-cytokine receptor interaction (KEGG):04060 |
2.83362949156361e-07 | 2.56241066879967e-05 | 10 | 189 | Chemokine signaling pathway (KEGG):04062 |
0.000142415808891857 | 0.00360596828114183 | 6 | 128 | Osteoclast differentiation (KEGG):04380 |
3.26488961192038e-06 | 0.0001722229270288 | 7 | 102 | Toll-like receptor signaling pathway (KEGG):04620 |
7.6754234857827e-05 | 0.00211241002891324 | 5 | 71 | RIG-I-like receptor signaling pathway (KEGG):04622 |
0.000400315152011088 | 0.00873791349044892 | 6 | 155 | Jak-STAT signaling pathway (KEGG):04630 |
0.000190417894746639 | 0.00446424175461565 | 6 | 135 | Hepatitis C (KEGG):05160 |
0.00144381959924493 | 0.0247010217924876 | 5 | 134 | Measles (KEGG):05162 |
1.4608798515914e-07 | 1.84947389211471e-05 | 10 | 176 | Influenza A (KEGG):05164 |
0.000913001698959126 | 0.0165122878697465 | 4 | 70 | Pancreatic cancer (KEGG):05212 |
6.69102128324949e-05 | 0.00192518930558951 | 5 | 69 | IL-5 Signaling Pathway (Wikipathways):WP127 |
0.000104974659925711 | 0.00276870665554062 | 4 | 40 | NOD pathway (Wikipathways):WP1433 |
2.18961022332174e-07 | 2.31003878560444e-05 | 9 | 140 | Regulation of toll-like receptor signaling pathway (Wikipathways):WP1449 |
0.000613193606796779 | 0.0121297360344488 | 4 | 63 | Folate Metabolism (Wikipathways):WP176 |
0.00265104168519505 | 0.0390257996913597 | 5 | 154 | Integrated Breast Cancer Pathway (Wikipathways):WP1984 |
0.00249377294623911 | 0.0375847208326037 | 3 | 44 | IL-7 Signaling Pathway (Wikipathways):WP205 |
6.36805878560101e-05 | 0.00191951486251687 | 7 | 161 | B Cell Receptor Signaling Pathway (Wikipathways):WP23 |
1.42675801788839e-05 | 0.000602091883548901 | 6 | 85 | Apoptosis (Wikipathways):WP254 |
0.000864927440927483 | 0.0161029138266793 | 4 | 69 | Kit Receptor Signaling Pathway (Wikipathways):WP304 |
4.65289416476579e-05 | 0.00155014842436671 | 5 | 64 | IL-4 signaling Pathway (Wikipathways):WP395 |
0.000853068521147919 | 0.0161029138266793 | 6 | 179 | EGFR1 Signaling Pathway (Wikipathways):WP437 |
4.83471710190053e-07 | 3.8254699068788e-05 | 7 | 77 | IL-2 Signaling Pathway (Wikipathways):WP49 |
2.49068494027146e-05 | 0.000927413863054021 | 4 | 28 | Interferon type I (Wikipathways):WP585 |
0.000384721339507335 | 0.00869745028243368 | 5 | 100 | Senescence and Autophagy (Wikipathways):WP615 |
1.01583700518889e-14 | 3.21512412142283e-12 | 11 | 50 | Type II interferon signaling (IFNG) (Wikipathways):WP619 |
0.000175566491294813 | 0.00427436880729295 | 6 | 133 | T Cell Receptor Signaling Pathway (Wikipathways):WP69 |
3.26488961192038e-06 | 0.0001722229270288 | 7 | 102 | Toll-like receptor signaling pathway (Wikipathways):WP75 |
1.08374208480388e-18 | 6.86008739680854e-16 | 28 | 511 | Signaling in Immune system (Reactome):REACT_6900 |
0.00243356043581403 | 0.0375717989236654 | 6 | 220 | Signalling by NGF (Reactome):REACT_11061 |
0.000533073878378581 | 0.0112478588337881 | 14 | 816 | TGF beta receptor up reg. targets (Netpath):NetPath_7 |
7.66592931437817e-07 | 5.39170361777931e-05 | 18 | 740 | TGF beta receptor down reg. targets (Netpath):NetPath_7 |
0.000582751631961468 | 0.0118994123558584 | 13 | 728 | TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9 |
2.25351860978225e-05 | 0.000891548299995101 | 9 | 246 | B Cell Receptor up reg. targets (Netpath):NetPath_12 |
5.43508521681929e-06 | 0.000264646841711278 | 8 | 155 | IL-1 up reg. targets (Netpath):NetPath_13 |
8.15146157745929e-08 | 1.28996879463293e-05 | 15 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
0.00237036350084465 | 0.0375110024008666 | 7 | 295 | IL-2 down reg. targets (Netpath):NetPath_14 |
0.00189399256404034 | 0.0307409562317317 | 3 | 40 | IL-3 up reg. targets (Netpath):NetPath_15 |
6.13559192634185e-05 | 0.00191951486251687 | 8 | 217 | IL-4 up reg. targets (Netpath):NetPath_16 |
1.40493400028764e-06 | 8.89323222182073e-05 | 7 | 90 | IL-4 down reg. targets (Netpath):NetPath_16 |
5.62565482669598e-10 | 1.18701316843285e-07 | 11 | 131 | IL-5 up reg. targets (Netpath):NetPath_17 |
1.00541308434114e-05 | 0.000454590344562815 | 6 | 80 | IL-6 up reg. targets (Netpath):NetPath_18 |
0.00323973424938462 | 0.0466079949968287 | 2 | 14 | IL-7 down reg. targets (Netpath):NetPath_19 |
0.00175981622123175 | 0.0293148333694657 | 3 | 39 | {CASP3,41} (Static Module):NA |
0.000945038368404978 | 0.0166169246444542 | 9 | 406 | {GRB2,414} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0002376 | immune system process | 2.04931491108874e-22 |
GO:0006955 | immune response | 4.25542578510859e-20 |
GO:0048869 | cellular developmental process | 5.52603342113195e-15 |
GO:0030154 | cell differentiation | 5.52603342113195e-15 |
GO:0005515 | protein binding | 2.57204122660213e-13 |
GO:0048523 | negative regulation of cellular process | 5.54476306940542e-10 |
GO:0048513 | organ development | 5.54476306940542e-10 |
GO:0048519 | negative regulation of biological process | 1.96367747032347e-09 |
GO:0032502 | developmental process | 2.41104026218938e-09 |
GO:0048468 | cell development | 1.02229396478808e-08 |
GO:0065007 | biological regulation | 1.27329817867407e-08 |
GO:0050789 | regulation of biological process | 6.76856693678468e-08 |
GO:0050794 | regulation of cellular process | 8.52794439067552e-08 |
GO:0048731 | system development | 3.37770978161969e-07 |
GO:0006952 | defense response | 7.76316040471521e-07 |
GO:0009615 | response to virus | 1.20387532241787e-06 |
GO:0008219 | cell death | 1.87141136670573e-06 |
GO:0016265 | death | 1.87141136670573e-06 |
GO:0042981 | regulation of apoptosis | 3.10792514020392e-06 |
GO:0043067 | regulation of programmed cell death | 3.38372117773017e-06 |
GO:0006915 | apoptosis | 3.51544586260349e-06 |
GO:0012501 | programmed cell death | 3.79057652434492e-06 |
GO:0005737 | cytoplasm | 1.41914917497262e-05 |
GO:0048522 | positive regulation of cellular process | 1.55086555391471e-05 |
GO:0005062 | hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity | 1.86435139643539e-05 |
GO:0051707 | response to other organism | 2.03937695334459e-05 |
GO:0048856 | anatomical structure development | 2.23580633340776e-05 |
GO:0009607 | response to biotic stimulus | 3.59513317289658e-05 |
GO:0009605 | response to external stimulus | 4.68992283973073e-05 |
GO:0044424 | intracellular part | 5.42178615031973e-05 |
GO:0030099 | myeloid cell differentiation | 5.42178615031973e-05 |
GO:0048518 | positive regulation of biological process | 5.42178615031973e-05 |
GO:0002521 | leukocyte differentiation | 0.00013146678893299 |
GO:0009611 | response to wounding | 0.000132130896440254 |
GO:0007275 | multicellular organismal development | 0.000137037572451955 |
GO:0032501 | multicellular organismal process | 0.000233225168049701 |
GO:0006954 | inflammatory response | 0.000245767104766667 |
GO:0030097 | hemopoiesis | 0.000293168745362596 |
GO:0002573 | myeloid leukocyte differentiation | 0.000327093857030976 |
GO:0044464 | cell part | 0.000382339554254106 |
GO:0001816 | cytokine production | 0.000394845123550258 |
GO:0048534 | hemopoietic or lymphoid organ development | 0.000423615876747522 |
GO:0042221 | response to chemical stimulus | 0.000439171963869114 |
GO:0002520 | immune system development | 0.000561283977550572 |
GO:0051704 | multi-organism process | 0.000590112710190111 |
GO:0008009 | chemokine activity | 0.000686658409232106 |
GO:0042379 | chemokine receptor binding | 0.000716159041291623 |
GO:0007259 | JAK-STAT cascade | 0.000773216869787527 |
GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 0.00106812224639256 |
GO:0019221 | cytokine and chemokine mediated signaling pathway | 0.00109845940184638 |
GO:0006935 | chemotaxis | 0.00122650567475901 |
GO:0042330 | taxis | 0.00122650567475901 |
GO:0007243 | protein kinase cascade | 0.00128828572558078 |
GO:0045449 | regulation of transcription | 0.00148364524973606 |
GO:0007260 | tyrosine phosphorylation of STAT protein | 0.00160842016974691 |
GO:0010468 | regulation of gene expression | 0.00160842016974691 |
GO:0005622 | intracellular | 0.00160842016974691 |
GO:0019899 | enzyme binding | 0.00165020106042388 |
GO:0005125 | cytokine activity | 0.00181627856557638 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00200349311194237 |
GO:0050663 | cytokine secretion | 0.00204946154932636 |
GO:0003700 | transcription factor activity | 0.00204946154932636 |
GO:0001664 | G-protein-coupled receptor binding | 0.00225867132750561 |
GO:0030224 | monocyte differentiation | 0.00248408607713838 |
GO:0043122 | regulation of I-kappaB kinase/NF-kappaB cascade | 0.00261602544262239 |
GO:0031323 | regulation of cellular metabolic process | 0.00265353131956912 |
GO:0008283 | cell proliferation | 0.00268156843737764 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.00289456874401467 |
GO:0043065 | positive regulation of apoptosis | 0.00307094059980835 |
GO:0006350 | transcription | 0.00309531200459305 |
GO:0043068 | positive regulation of programmed cell death | 0.00312110801910146 |
GO:0007626 | locomotory behavior | 0.00312110801910146 |
GO:0007242 | intracellular signaling cascade | 0.00314355404862467 |
GO:0019222 | regulation of metabolic process | 0.00325342291760973 |
GO:0006512 | ubiquitin cycle | 0.00332480907414649 |
GO:0019207 | kinase regulator activity | 0.00395858995952148 |
GO:0009887 | organ morphogenesis | 0.00401880590138388 |
GO:0042301 | phosphate binding | 0.00506583000517576 |
GO:0043231 | intracellular membrane-bound organelle | 0.0057660237224233 |
GO:0043227 | membrane-bound organelle | 0.0057660237224233 |
GO:0001775 | cell activation | 0.00598478165379157 |
GO:0007610 | behavior | 0.00598478165379157 |
GO:0006917 | induction of apoptosis | 0.00632486519487323 |
GO:0012502 | induction of programmed cell death | 0.00640746349540556 |
GO:0043283 | biopolymer metabolic process | 0.00718292412371004 |
GO:0019901 | protein kinase binding | 0.00826137519618881 |
GO:0045786 | negative regulation of progression through cell cycle | 0.00826137519618881 |
GO:0042771 | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | 0.00833277519435027 |
GO:0008629 | induction of apoptosis by intracellular signals | 0.00842126389558695 |
GO:0051329 | interphase of mitotic cell cycle | 0.00866460400587848 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.00880292440556492 |
GO:0007267 | cell-cell signaling | 0.00903197713829527 |
GO:0009967 | positive regulation of signal transduction | 0.00914381392986915 |
GO:0003950 | NAD+ ADP-ribosyltransferase activity | 0.00935952387996985 |
GO:0044237 | cellular metabolic process | 0.0094322306170733 |
GO:0042516 | regulation of tyrosine phosphorylation of Stat3 protein | 0.00979211284503215 |
GO:0051325 | interphase | 0.00997267026623332 |
GO:0042503 | tyrosine phosphorylation of Stat3 protein | 0.0118179542215812 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 0.0118179542215812 |
GO:0019210 | kinase inhibitor activity | 0.0118179542215812 |
GO:0008639 | small protein conjugating enzyme activity | 0.0121518495503619 |
GO:0009966 | regulation of signal transduction | 0.0125053653937382 |
GO:0006351 | transcription, DNA-dependent | 0.0126269066280285 |
GO:0043170 | macromolecule metabolic process | 0.0127504889060913 |
GO:0032774 | RNA biosynthetic process | 0.0127504889060913 |
GO:0018212 | peptidyl-tyrosine modification | 0.0127788900948737 |
GO:0019900 | kinase binding | 0.0127946243405622 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | 0.0127946243405622 |
GO:0005159 | insulin-like growth factor receptor binding | 0.0129652240375776 |
GO:0007090 | regulation of S phase of mitotic cell cycle | 0.0129652240375776 |
GO:0000074 | regulation of progression through cell cycle | 0.0129652240375776 |
GO:0051726 | regulation of cell cycle | 0.0141584581728631 |
GO:0016070 | RNA metabolic process | 0.014163468674623 |
GO:0042127 | regulation of cell proliferation | 0.0147541183613308 |
GO:0045321 | leukocyte activation | 0.0152986239648343 |
GO:0042509 | regulation of tyrosine phosphorylation of STAT protein | 0.0172060680678069 |
GO:0050715 | positive regulation of cytokine secretion | 0.0172060680678069 |
GO:0002252 | immune effector process | 0.0172955303071828 |
GO:0051239 | regulation of multicellular organismal process | 0.0176493784134082 |
GO:0031324 | negative regulation of cellular metabolic process | 0.0185120474722734 |
GO:0043687 | post-translational protein modification | 0.0185120474722734 |
GO:0045087 | innate immune response | 0.0190389160679225 |
GO:0009595 | detection of biotic stimulus | 0.0190389160679225 |
GO:0006950 | response to stress | 0.0212141190446014 |
GO:0002697 | regulation of immune effector process | 0.0212141190446014 |
GO:0046425 | regulation of JAK-STAT cascade | 0.0212141190446014 |
GO:0033261 | regulation of progression through S phase | 0.0212141190446014 |
GO:0009306 | protein secretion | 0.0224149903251553 |
GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0229953718946196 |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 0.0229953718946196 |
GO:0050707 | regulation of cytokine secretion | 0.0229953718946196 |
GO:0050714 | positive regulation of protein secretion | 0.0229953718946196 |
GO:0051607 | defense response to virus | 0.0229953718946196 |
GO:0008234 | cysteine-type peptidase activity | 0.0229953718946196 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0232071371601787 |
GO:0007154 | cell communication | 0.0236074625618326 |
GO:0005102 | receptor binding | 0.0236074625618326 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.0249592671797786 |
GO:0000084 | S phase of mitotic cell cycle | 0.0249592671797786 |
GO:0005615 | extracellular space | 0.0250978341999601 |
GO:0044267 | cellular protein metabolic process | 0.0251151474995319 |
GO:0044238 | primary metabolic process | 0.026513121765228 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0279182990654178 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0292502552616485 |
GO:0043412 | biopolymer modification | 0.0292502552616485 |
GO:0007281 | germ cell development | 0.0292502552616485 |
GO:0008630 | DNA damage response, signal transduction resulting in induction of apoptosis | 0.0292502552616485 |
GO:0051250 | negative regulation of lymphocyte activation | 0.0292502552616485 |
GO:0030155 | regulation of cell adhesion | 0.0292502552616485 |
GO:0008285 | negative regulation of cell proliferation | 0.0308870006884819 |
GO:0044260 | cellular macromolecule metabolic process | 0.0309715516136739 |
GO:0009892 | negative regulation of metabolic process | 0.0310067445755624 |
GO:0019538 | protein metabolic process | 0.0312750701736084 |
GO:0004197 | cysteine-type endopeptidase activity | 0.0312750701736084 |
GO:0051320 | S phase | 0.0312750701736084 |
GO:0051047 | positive regulation of secretion | 0.0312750701736084 |
GO:0007165 | signal transduction | 0.0312750701736084 |
GO:0000060 | protein import into nucleus, translocation | 0.0312750701736084 |
GO:0006464 | protein modification process | 0.0312750701736084 |
GO:0017001 | antibiotic catabolic process | 0.0312750701736084 |
GO:0008917 | lipopolysaccharide N-acetylglucosaminyltransferase activity | 0.0312750701736084 |
GO:0048407 | platelet-derived growth factor binding | 0.0312750701736084 |
GO:0016804 | prolyl aminopeptidase activity | 0.0312750701736084 |
GO:0048294 | negative regulation of isotype switching to IgE isotypes | 0.0312750701736084 |
GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity | 0.0312750701736084 |
GO:0030653 | beta-lactam antibiotic metabolic process | 0.0312750701736084 |
GO:0033595 | response to genistein | 0.0312750701736084 |
GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 0.0312750701736084 |
GO:0002355 | detection of tumor cell | 0.0312750701736084 |
GO:0005018 | platelet-derived growth factor alpha-receptor activity | 0.0312750701736084 |
GO:0030423 | RNA interference, targeting of mRNA for destruction | 0.0312750701736084 |
GO:0032498 | detection of muramyl dipeptide | 0.0312750701736084 |
GO:0030655 | beta-lactam antibiotic catabolic process | 0.0312750701736084 |
GO:0030852 | regulation of granulocyte differentiation | 0.0312750701736084 |
GO:0043379 | memory T cell differentiation | 0.0312750701736084 |
GO:0030854 | positive regulation of granulocyte differentiation | 0.0312750701736084 |
GO:0043380 | regulation of memory T cell differentiation | 0.0312750701736084 |
GO:0008800 | beta-lactamase activity | 0.0312750701736084 |
GO:0032500 | muramyl dipeptide binding | 0.0312750701736084 |
GO:0032926 | negative regulation of activin receptor signaling pathway | 0.0312750701736084 |
GO:0035030 | phosphoinositide 3-kinase complex, class IA | 0.0312750701736084 |
GO:0004408 | holocytochrome-c synthase activity | 0.0312750701736084 |
GO:0043031 | negative regulation of macrophage activation | 0.0312750701736084 |
GO:0042523 | positive regulation of tyrosine phosphorylation of Stat5 protein | 0.0312750701736084 |
GO:0048250 | mitochondrial iron ion transport | 0.0312750701736084 |
GO:0030422 | RNA interference, production of siRNA | 0.0312750701736084 |
GO:0004218 | cathepsin S activity | 0.0312750701736084 |
GO:0032490 | detection of molecule of bacterial origin | 0.0312750701736084 |
GO:0032495 | response to muramyl dipeptide | 0.0312750701736084 |
GO:0033593 | BRCA2-MAGE-D1 complex | 0.0312750701736084 |
GO:0032499 | detection of peptidoglycan | 0.0312750701736084 |
GO:0032494 | response to peptidoglycan | 0.0312750701736084 |
GO:0045829 | negative regulation of isotype switching | 0.0312750701736084 |
GO:0051092 | activation of NF-kappaB transcription factor | 0.0326920427182347 |
GO:0006508 | proteolysis | 0.0346114617683344 |
GO:0016787 | hydrolase activity | 0.0346114617683344 |
GO:0016763 | transferase activity, transferring pentosyl groups | 0.0377749291994716 |
GO:0050865 | regulation of cell activation | 0.0377749291994716 |
GO:0050708 | regulation of protein secretion | 0.0403822404085943 |
GO:0007162 | negative regulation of cell adhesion | 0.0403822404085943 |
GO:0000151 | ubiquitin ligase complex | 0.0409576468755775 |
GO:0016607 | nuclear speck | 0.0409576468755775 |
GO:0043226 | organelle | 0.0409576468755775 |
GO:0004842 | ubiquitin-protein ligase activity | 0.0417714048545602 |
GO:0042157 | lipoprotein metabolic process | 0.0417714048545602 |
GO:0002274 | myeloid leukocyte activation | 0.0420157996550589 |
GO:0003705 | RNA polymerase II transcription factor activity, enhancer binding | 0.0420157996550589 |
GO:0010467 | gene expression | 0.0421964868119728 |
GO:0007276 | gamete generation | 0.0432736196148453 |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 0.044261331185689 |
GO:0048754 | branching morphogenesis of a tube | 0.044261331185689 |
GO:0022402 | cell cycle process | 0.0450697953688119 |
GO:0009653 | anatomical structure morphogenesis | 0.0464387897537615 |
GO:0003677 | DNA binding | 0.0484527379444247 |
GO:0051091 | positive regulation of transcription factor activity | 0.0484527379444247 |
GO:0005057 | receptor signaling protein activity | 0.0484527379444247 |
GO:0045941 | positive regulation of transcription | 0.0484527379444247 |
GO:0033598 | mammary gland epithelial cell proliferation | 0.0484527379444247 |
GO:0045629 | negative regulation of T-helper 2 cell differentiation | 0.0484527379444247 |
GO:0032764 | negative regulation of mast cell cytokine production | 0.0484527379444247 |
GO:0031050 | dsRNA fragmentation | 0.0484527379444247 |
GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity | 0.0484527379444247 |
GO:0048641 | regulation of skeletal muscle development | 0.0484527379444247 |
GO:0006581 | acetylcholine catabolic process | 0.0484527379444247 |
GO:0016246 | RNA interference | 0.0484527379444247 |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 0.0484527379444247 |
GO:0002902 | regulation of B cell apoptosis | 0.0484527379444247 |
GO:0030349 | syntaxin-13 binding | 0.0484527379444247 |
GO:0004217 | cathepsin L activity | 0.0484527379444247 |
GO:0045029 | UDP-activated nucleotide receptor activity | 0.0484527379444247 |
GO:0033599 | regulation of mammary gland epithelial cell proliferation | 0.0484527379444247 |
GO:0045623 | negative regulation of T-helper cell differentiation | 0.0484527379444247 |
GO:0002903 | negative regulation of B cell apoptosis | 0.0484527379444247 |
GO:0002634 | regulation of germinal center formation | 0.0484527379444247 |
GO:0035196 | miRNA-mediated gene silencing, production of miRNAs | 0.0484527379444247 |
GO:0001507 | acetylcholine catabolic process in synaptic cleft | 0.0484527379444247 |
GO:0035024 | negative regulation of Rho protein signal transduction | 0.0484527379444247 |
GO:0004105 | choline-phosphate cytidylyltransferase activity | 0.0484527379444247 |
GO:0048478 | replication fork protection | 0.0484527379444247 |
GO:0019005 | SCF ubiquitin ligase complex | 0.0484527379444247 |
GO:0035195 | miRNA-mediated gene silencing | 0.0484527379444247 |
GO:0043559 | insulin binding | 0.0484527379444247 |
GO:0042772 | DNA damage response, signal transduction resulting in transcription | 0.0484527379444247 |
GO:0048179 | activin receptor complex | 0.0484527379444247 |
GO:0004178 | leucyl aminopeptidase activity | 0.0484527379444247 |
GO:0042522 | regulation of tyrosine phosphorylation of Stat5 protein | 0.0484527379444247 |
GO:0046653 | tetrahydrofolate metabolic process | 0.0484527379444247 |
GO:0007346 | regulation of progression through mitotic cell cycle | 0.0484527379444247 |
GO:0001763 | morphogenesis of a branching structure | 0.0484527379444247 |
GO:0008286 | insulin receptor signaling pathway | 0.0484527379444247 |
GO:0008233 | peptidase activity | 0.0485189475958085 |
GO:0006606 | protein import into nucleus | 0.0490259751643505 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
bone marrow | 1.09e-73 | 76 |
bone element | 6.21e-68 | 82 |
hematopoietic system | 2.20e-63 | 98 |
blood island | 2.20e-63 | 98 |
skeletal element | 1.95e-61 | 90 |
immune system | 2.76e-59 | 93 |
hemolymphoid system | 5.14e-57 | 108 |
skeletal system | 9.21e-55 | 100 |
musculoskeletal system | 1.68e-30 | 167 |
lateral plate mesoderm | 1.34e-27 | 203 |
mesoderm | 1.43e-15 | 315 |
mesoderm-derived structure | 1.43e-15 | 315 |
presumptive mesoderm | 1.43e-15 | 315 |
connective tissue | 2.71e-13 | 371 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0 |
MA0004.1 | 0.257704 |
MA0006.1 | 0.00174017 |
MA0007.1 | 0.00357108 |
MA0009.1 | 0.3178 |
MA0014.1 | 0 |
MA0017.1 | 0.367671 |
MA0019.1 | 0.426719 |
MA0024.1 | 4.71383e-05 |
MA0025.1 | 4.34152 |
MA0027.1 | 0.299803 |
MA0028.1 | 4.4107e-10 |
MA0029.1 | 1.37557 |
MA0030.1 | 0.299433 |
MA0031.1 | 0.214231 |
MA0038.1 | 0.194214 |
MA0040.1 | 1.32359 |
MA0041.1 | 0.154577 |
MA0042.1 | 0.443566 |
MA0043.1 | 2.30732 |
MA0046.1 | 1.13256 |
MA0048.1 | 5.93061e-15 |
MA0050.1 | 40.4293 |
MA0051.1 | 37.2573 |
MA0052.1 | 1.3799 |
MA0055.1 | 1.44649e-16 |
MA0056.1 | 0 |
MA0057.1 | 3.42216e-12 |
MA0058.1 | 0.218053 |
MA0059.1 | 0.0458632 |
MA0060.1 | 1.79819e-09 |
MA0061.1 | 0.711029 |
MA0063.1 | 0 |
MA0066.1 | 0.0167418 |
MA0067.1 | 0.465634 |
MA0068.1 | 0.00109189 |
MA0069.1 | 1.68673 |
MA0070.1 | 0.034941 |
MA0071.1 | 2.23493 |
MA0072.1 | 1.03553 |
MA0073.1 | 0 |
MA0074.1 | 0.119131 |
MA0076.1 | 0.0017611 |
MA0077.1 | 0.537902 |
MA0078.1 | 2.94063 |
MA0081.1 | 4.26832 |
MA0083.1 | 1.68629 |
MA0084.1 | 0.888549 |
MA0087.1 | 0.181443 |
MA0088.1 | 2.86887e-14 |
MA0089.1 | 0 |
MA0090.1 | 0.00289151 |
MA0091.1 | 2.84149 |
MA0092.1 | 0.488715 |
MA0093.1 | 0.145033 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.330913 |
MA0101.1 | 2.55578 |
MA0103.1 | 1.68421e-05 |
MA0105.1 | 2.89298e-16 |
MA0106.1 | 0.000257352 |
MA0107.1 | 3.14718 |
MA0108.2 | 0.694305 |
MA0109.1 | 0 |
MA0111.1 | 0.000943363 |
MA0113.1 | 0.441313 |
MA0114.1 | 0.00833336 |
MA0115.1 | 0.146096 |
MA0116.1 | 1.23597e-08 |
MA0117.1 | 0.140938 |
MA0119.1 | 0.0909735 |
MA0122.1 | 0.347401 |
MA0124.1 | 1.57522 |
MA0125.1 | 0.773918 |
MA0130.1 | 0 |
MA0131.1 | 0.000545354 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.488947 |
MA0136.1 | 16.4769 |
MA0139.1 | 0 |
MA0140.1 | 0.290234 |
MA0141.1 | 0.502516 |
MA0142.1 | 1.21566 |
MA0143.1 | 0.500011 |
MA0144.1 | 81.0238 |
MA0145.1 | 4.82164e-17 |
MA0146.1 | 0 |
MA0147.1 | 4.0299e-10 |
MA0148.1 | 1.39926 |
MA0149.1 | 0.000168942 |
MA0062.2 | 0.00090717 |
MA0035.2 | 0.503386 |
MA0039.2 | 0 |
MA0138.2 | 0.00986163 |
MA0002.2 | 3.23526 |
MA0137.2 | 143.579 |
MA0104.2 | 1.66052e-12 |
MA0047.2 | 0.535891 |
MA0112.2 | 1.84669e-13 |
MA0065.2 | 9.07867e-05 |
MA0150.1 | 12.4269 |
MA0151.1 | 0 |
MA0152.1 | 8.62605 |
MA0153.1 | 0.541348 |
MA0154.1 | 1.77117e-07 |
MA0155.1 | 0 |
MA0156.1 | 19.4031 |
MA0157.1 | 1.44765 |
MA0158.1 | 0 |
MA0159.1 | 0.00327468 |
MA0160.1 | 6.1069 |
MA0161.1 | 0 |
MA0162.1 | 0 |
MA0163.1 | 0 |
MA0164.1 | 2.21497 |
MA0080.2 | 30.6093 |
MA0018.2 | 0.0185669 |
MA0099.2 | 40.5486 |
MA0079.2 | 0 |
MA0102.2 | 2.99768 |
MA0258.1 | 0.109402 |
MA0259.1 | 1.73295e-10 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
BATF#10538 | 248 | 3.19109077891775 | 1.24244916686753e-57 | 1.09042141628973e-54 |
BCL11A#53335 | 200 | 2.99730112029657 | 2.40232457439097e-42 | 1.45026807066369e-39 |
BCL3#602 | 77 | 1.40524401261904 | 0.00220456305381441 | 0.0127023259835222 |
CEBPB#1051 | 456 | 1.92014966580883 | 1.64063903543628e-43 | 1.0322090374815e-40 |
EBF1#1879 | 369 | 1.7361258670808 | 4.64464008168152e-26 | 1.54978135939532e-23 |
EP300#2033 | 481 | 1.72121815653109 | 4.25826606405863e-34 | 2.01234864010959e-31 |
FOS#2353 | 443 | 2.10570216684639 | 2.19748068397135e-52 | 1.72558409889687e-49 |
FOSL1#8061 | 155 | 3.25177224302051 | 9.24093415956857e-37 | 4.82556961345591e-34 |
FOSL2#2355 | 157 | 1.40414236392825 | 1.59338949133812e-05 | 0.000372536389267656 |
GATA1#2623 | 214 | 1.53296668926217 | 4.93788614951882e-10 | 4.78393220379959e-08 |
GATA2#2624 | 332 | 2.2352442343053 | 2.5570165495546e-43 | 1.58959673463651e-40 |
GATA3#2625 | 91 | 1.30930955547055 | 0.00644035383907289 | 0.0279956761258193 |
IRF4#3662 | 199 | 2.30374433421135 | 3.81692445629669e-27 | 1.33323001100726e-24 |
JUN#3725 | 394 | 2.60436064542024 | 3.05383381663373e-69 | 3.1893934997541e-66 |
JUNB#3726 | 185 | 2.99153039728838 | 4.84752586986393e-39 | 2.72188577592859e-36 |
JUND#3727 | 433 | 1.59994162008989 | 8.37287400792207e-24 | 2.549430287211e-21 |
KAT2A#2648 | 8 | 2.60365557316429 | 0.0130003252839428 | 0.0461298872805932 |
MAFF#23764 | 81 | 2.40969037278688 | 1.2545627204091e-12 | 1.74700367942408e-10 |
MAFK#7975 | 182 | 2.60556441156104 | 5.56789338773594e-31 | 2.30756038699109e-28 |
MAX#4149 | 353 | 1.20324991795009 | 0.000113215104947069 | 0.00155090140943953 |
MEF2A#4205 | 229 | 2.26740616920681 | 2.69160030927219e-30 | 1.08956606472899e-27 |
MEF2C#4208 | 93 | 2.0295594124744 | 2.67904702713271e-10 | 2.72706620337927e-08 |
NFE2#4778 | 46 | 1.87606761224244 | 5.52708024081968e-05 | 0.000935411980669206 |
NFKB1#4790 | 488 | 1.4147781040711 | 1.70553836395092e-16 | 3.39285183224133e-14 |
NR3C1#2908 | 161 | 1.2734584027041 | 0.00115020753324271 | 0.00786683199504488 |
POU2F2#5452 | 250 | 1.20260486763636 | 0.00134023310053875 | 0.0088781304571335 |
PRDM1#639 | 50 | 3.48206433643584 | 8.63467645706071e-14 | 1.36223107930357e-11 |
RXRA#6256 | 120 | 1.27255893116534 | 0.0047942217639784 | 0.0225268244391119 |
SIRT6#51548 | 22 | 1.78554933321741 | 0.00756967469037177 | 0.0312009335775411 |
SMARCA4#6597 | 22 | 1.82189639343557 | 0.00606812667873771 | 0.0268446747797648 |
SMARCC1#6599 | 89 | 2.05284679315753 | 3.75689865638623e-10 | 3.73327058776709e-08 |
SPI1#6688 | 486 | 2.10633979141154 | 2.89281382676076e-58 | 2.67365117923068e-55 |
SRF#6722 | 178 | 1.29735749110717 | 0.000270607926726075 | 0.00288889106197941 |
STAT1#6772 | 475 | 5.19578925576842 | 1.13825246312554e-198 | 4.75511795985471e-195 |
STAT2#6773 | 192 | 6.61946332160413 | 2.66911657782645e-94 | 3.98228380388024e-91 |
STAT3#6774 | 667 | 3.70654154944632 | 4.89242193498118e-207 | 2.32254388394318e-203 |
TAL1#6886 | 118 | 1.8618577749276 | 1.95548864996546e-10 | 2.03011211842687e-08 |
TCF12#6938 | 215 | 1.20782353617014 | 0.00241559468734663 | 0.013614802674139 |
USF2#7392 | 177 | 1.21480134028384 | 0.00462770818496673 | 0.0218535546721713 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data