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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0

Latest revision as of 12:22, 17 September 2013


Full id: C3246_hepatoma_hepatocellular_rhabdomyosarcoma_hepatoblastoma_liver_Prostate_Intestinal



Phase1 CAGE Peaks

Hg19::chr12:121416455..121416479,+p2@HNF1A
Hg19::chr12:121416489..121416503,+p4@HNF1A
Hg19::chr19:51857495..51857576,-p@chr19:51857495..51857576
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
metabolising cell2.19e-1612
endopolyploid cell2.19e-1612
parenchymal cell2.19e-1612
polyploid cell2.19e-1612
hepatocyte2.19e-1612
endodermal cell2.83e-1358
epithelial cell of stomach5.64e-083
epithelial cell5.37e-07253
Uber Anatomy
Ontology termp-valuen
gastrointestinal system9.35e-2325
intestine1.14e-2217
subdivision of digestive tract1.97e-15118
hepatic diverticulum5.88e-1522
liver primordium5.88e-1522
digestive tract diverticulum2.99e-1423
liver1.53e-1319
digestive gland1.53e-1319
liver bud1.53e-1319
epithelial sac5.21e-1325
epithelium of foregut-midgut junction5.21e-1325
anatomical boundary5.21e-1325
hepatobiliary system5.21e-1325
foregut-midgut junction5.21e-1325
septum transversum5.21e-1325
rectum9.14e-134
sac1.85e-1226
large intestine4.82e-1211
abdomen element6.40e-1254
abdominal segment element6.40e-1254
digestive system1.01e-11145
digestive tract1.01e-11145
primitive gut1.01e-11145
abdominal segment of trunk1.72e-1060
abdomen1.72e-1060
gut epithelium2.46e-1054
lower digestive tract2.62e-105
endoderm-derived structure3.31e-10160
endoderm3.31e-10160
presumptive endoderm3.31e-10160
small intestine4.34e-104
exocrine gland6.29e-0831
exocrine system6.29e-0831
trunk region element1.88e-07101
endo-epithelium2.57e-0782
endocrine gland6.50e-0735
organ system subdivision9.27e-07223
Disease
Ontology termp-valuen
carcinoma1.88e-12106
adenocarcinoma3.42e-1225
signet ring cell adenocarcinoma3.78e-112
gastrointestinal system cancer2.36e-0914
cell type cancer2.42e-09143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.11.64148
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.12.854
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.18.86238
MA0074.12.15449
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.12.32521
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.12.37462
MA0148.11.98824
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.23.15214
MA0047.22.23118
MA0112.22.07067
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.12.47657
MA0158.10
MA0159.11.38935
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.21.90288
MA0102.21.88331
MA0258.12.22591
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553229.91454236465160.001467483527106140.0093945391741718
FOSL2#2355211.28680040304110.0100534586973120.037660443790838
FOXA2#3170216.42030916844350.004810682352105480.0225777582425536
HNF4A#3172215.42152690863580.005444210486686610.0246697283503585
HNF4G#3174219.16894835096450.003543986611284220.0179683682555421
NR3C1#290829.982015554115360.01278474365547170.0460168818112011
RXRA#6256320.07461713913330.0001235730348432220.0016488877201982



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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