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Coexpression cluster:C4313: Difference between revisions

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{{Coexpression_clusters
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|full_id=C4313_normal_Lens_Ciliary_Chondrocyte_Mammary_large_Iris
|id=C4313
}}

Latest revision as of 12:43, 17 September 2013


Full id: C4313_normal_Lens_Ciliary_Chondrocyte_Mammary_large_Iris



Phase1 CAGE Peaks

Hg19::chr3:189838653..189838658,-p3@LEPREL1
Hg19::chr3:189838670..189838704,-p1@LEPREL1
Hg19::chr3:189838746..189838757,-p4@LEPREL1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
epithelial cell6.80e-12253
kidney cell8.66e-1017
kidney epithelial cell8.66e-1017
epithelial cell of nephron9.68e-0915
embryonic cell1.62e-08250
kidney tubule cell4.69e-0810
nephron tubule epithelial cell4.69e-0810
kidney cortical cell9.62e-0712
renal cortical epithelial cell9.62e-0712
Uber Anatomy
Ontology termp-valuen
multi-tissue structure1.16e-18342
anatomical cluster8.06e-17373
anatomical system5.06e-12624
anatomical group8.42e-12625
multi-cellular organism1.09e-11656
urinary system structure1.54e-1147
renal system2.17e-1148
organ2.44e-11503
cell layer2.80e-11309
epithelium9.46e-11306
organ part8.48e-10218
organism subdivision1.34e-09264
embryo1.66e-09592
ectodermal placode3.33e-0931
eye3.80e-0921
visual system3.80e-0921
kidney4.31e-0926
kidney mesenchyme4.31e-0926
upper urinary tract4.31e-0926
kidney rudiment4.31e-0926
kidney field4.31e-0926
anterior segment of eyeball4.32e-0914
camera-type eye5.26e-0920
simple eye5.26e-0920
immature eye5.26e-0920
ocular region5.26e-0920
eyeball of camera-type eye5.26e-0920
optic cup5.26e-0920
optic vesicle5.26e-0920
eye primordium5.26e-0920
excretory tube6.62e-0916
kidney epithelium6.62e-0916
developing anatomical structure7.42e-09581
sense organ9.12e-0924
sensory system9.12e-0924
entire sense organ system9.12e-0924
nephron epithelium9.68e-0915
renal tubule9.68e-0915
nephron tubule9.68e-0915
nephron9.68e-0915
uriniferous tubule9.68e-0915
nephrogenic mesenchyme9.68e-0915
face1.43e-0822
cavitated compound organ1.95e-0831
primordium2.65e-08160
endoderm-derived structure3.21e-08160
endoderm3.21e-08160
presumptive endoderm3.21e-08160
nephron tubule epithelium4.69e-0810
pigment epithelium of eye5.88e-0811
organ system subdivision6.27e-08223
ectoderm-derived structure1.61e-07171
ectoderm1.61e-07171
presumptive ectoderm1.61e-07171
digestive system4.31e-07145
digestive tract4.31e-07145
primitive gut4.31e-07145
mesenchyme5.08e-07160
entire embryonic mesenchyme5.08e-07160
abdomen element6.12e-0754
abdominal segment element6.12e-0754
trunk region element8.10e-07101
ecto-epithelium8.26e-07104
cortex of kidney9.62e-0712
renal parenchyma9.62e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.12.37507
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.11.77664
MA0091.10.829044
MA0092.10.785956
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.13.85295
MA0146.10.707589
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.838867
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.11.38935
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.09178
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553344.87181354697741.10603738662898e-050.000285288808649405
CTCF#1066435.360256373075030.0064925092527670.0280472854835264
E2F1#186934.907389214879320.008460985347239390.0326639133804138
NANOG#79923329.24477848101273.99627955670032e-050.000739619777817163
RAD21#5885310.35503389545630.0009004912073565420.00666381359066888
SMC3#9126315.04493284493280.0002935825420371870.00309993601332744
YY1#752834.911170749853860.008441455341808260.0330465984872596
ZNF263#1012738.221841637010680.001799043925565870.0109723399055229



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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