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Coexpression cluster:C912: Difference between revisions

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{{Coexpression_clusters
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|full_id=C912_CD14_mesothelioma_tenocyte_migratory_mesenchymal_spleen_CD14CD16
|id=C912
}}

Latest revision as of 11:33, 17 September 2013


Full id: C912_CD14_mesothelioma_tenocyte_migratory_mesenchymal_spleen_CD14CD16



Phase1 CAGE Peaks

Hg19::chr16:30727305..30727313,+p@chr16:30727305..30727313
+
Hg19::chr22:35777079..35777096,+p1@HMOX1
Hg19::chr22:35782669..35782693,+p8@HMOX1
Hg19::chr22:35782737..35782763,+p6@HMOX1
Hg19::chr22:35782834..35782851,+p4@HMOX1
Hg19::chr22:35782917..35782934,+p7@HMOX1
Hg19::chr22:35783010..35783044,+p2@HMOX1
Hg19::chr22:35789482..35789516,+p5@HMOX1
Hg19::chr22:35790125..35790153,+p3@HMOX1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
defensive cell4.65e-4048
phagocyte4.65e-4048
monopoietic cell2.83e-3859
monocyte2.83e-3859
monoblast2.83e-3859
promonocyte2.83e-3859
classical monocyte5.87e-3742
CD14-positive, CD16-negative classical monocyte5.87e-3742
macrophage dendritic cell progenitor2.57e-3661
myeloid lineage restricted progenitor cell1.19e-3466
granulocyte monocyte progenitor cell3.64e-3167
myeloid leukocyte6.17e-3072
stuff accumulating cell1.32e-2187
multi fate stem cell5.68e-19427
somatic stem cell4.97e-18433
myeloid cell1.13e-17108
common myeloid progenitor1.13e-17108
stem cell8.00e-17441
connective tissue cell1.22e-16361
mesenchymal cell3.36e-15354
nongranular leukocyte1.56e-12115
hematopoietic lineage restricted progenitor cell2.64e-11120
somatic cell3.05e-11588
leukocyte5.67e-11136
motile cell7.01e-11386
animal cell6.73e-07679
eukaryotic cell6.73e-07679
Uber Anatomy
Ontology termp-valuen
bone marrow2.47e-2976
immune system9.23e-2993
bone element5.68e-2782
skeletal element1.12e-2590
skeletal system2.36e-25100
musculoskeletal system2.05e-24167
hemolymphoid system3.26e-23108
hematopoietic system1.44e-2298
blood island1.44e-2298
mesoderm8.15e-17315
mesoderm-derived structure8.15e-17315
presumptive mesoderm8.15e-17315
connective tissue2.10e-16371
lateral plate mesoderm3.02e-15203


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0913842
MA0004.10.415381
MA0006.10.265592
MA0007.11.02827
MA0009.10.870971
MA0014.10.580022
MA0017.10.301634
MA0019.10.558663
MA0024.10.766783
MA0025.11.00397
MA0027.12.48103
MA0028.10.280275
MA0029.10.785955
MA0030.10.774581
MA0031.10.710608
MA0038.10.514558
MA0040.10.791764
MA0041.10.433167
MA0042.10.402577
MA0043.10.871285
MA0046.10.860127
MA0048.10.948258
MA0050.10.403421
MA0051.10.510444
MA0052.10.795605
MA0055.10.42489
MA0056.10
MA0057.10.0725989
MA0058.10.86817
MA0059.10.865474
MA0060.10.162248
MA0061.10.851955
MA0063.10
MA0066.10.514973
MA0067.11.18766
MA0068.10.109867
MA0069.10.856287
MA0070.10.845142
MA0071.10.47692
MA0072.10.840664
MA0073.10.987536
MA0074.10.509711
MA0076.10.339975
MA0077.10.832987
MA0078.10.607575
MA0081.10.324031
MA0083.10.878452
MA0084.11.37471
MA0087.10.838229
MA0088.10.158781
MA0089.10
MA0090.10.353576
MA0091.10.417885
MA0092.10.381858
MA0093.10.73976
MA0095.10
MA0098.10
MA0100.10.528088
MA0101.11.36936
MA0103.10.714036
MA0105.10.229733
MA0106.10.554855
MA0107.11.11943
MA0108.20.707575
MA0109.10
MA0111.10.366362
MA0113.10.57094
MA0114.10.200901
MA0115.11.11137
MA0116.10.599942
MA0117.10.908433
MA0119.10.83188
MA0122.10.934245
MA0124.11.06995
MA0125.10.986127
MA0130.10
MA0131.10.625452
MA0132.10
MA0133.10
MA0135.10.90122
MA0136.10.521435
MA0139.10.129876
MA0140.10.474342
MA0141.10.861836
MA0142.10.679161
MA0143.10.571113
MA0144.11.0529
MA0145.11.53859
MA0146.10.0045741
MA0147.10.211483
MA0148.10.439278
MA0149.10.464973
MA0062.20.135498
MA0035.20.473658
MA0039.20.00489248
MA0138.20.608783
MA0002.20.46405
MA0137.22.18049
MA0104.20.161609
MA0047.20.542971
MA0112.20.166662
MA0065.20.0483532
MA0150.10.34802
MA0151.10
MA0152.10.480711
MA0153.10.969315
MA0154.10.488402
MA0155.10.156896
MA0156.10.288314
MA0157.10.652111
MA0158.10
MA0159.10.212043
MA0160.11.15068
MA0161.10
MA0162.10.294626
MA0163.10.00648562
MA0164.10.583138
MA0080.20.268439
MA0018.20.556211
MA0099.20.481058
MA0079.29.34847e-05
MA0102.21.41188
MA0258.10.180288
MA0259.10.218904
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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